NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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4-Aminosalicylic acid
CAS:4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Formula:C7H7NO3Purity:97.07%Color and Shape:Minute Crystals From Alc SolidMolecular weight:153.14IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formula:C14H10N4O3Purity:99.67%Color and Shape:SolidMolecular weight:282.25BMS986299
CAS:BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Formula:C18H19N7OPurity:99.93% - 99.93%Color and Shape:SolidMolecular weight:349.39Esculentoside A
CAS:Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Formula:C42H66O16Purity:98% - 99.85%Color and Shape:SolidMolecular weight:826.96Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formula:C17H20O5Purity:98.2% - 98.96%Color and Shape:SolidMolecular weight:304.34Ref: TM-T3S1707
1mg104.00€2mg145.00€5mg227.00€10mg338.00€25mg558.00€50mg797.00€100mg1,074.00€1mL*10mM (DMSO)246.00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormula:C26H30N2O4Purity:98%Color and Shape:SolidMolecular weight:434.53DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NLRP3-IN-13
CAS:NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Formula:C19H15N3O3SPurity:98.82%Color and Shape:SolidMolecular weight:365.41E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Formula:C36H60O8Purity:99.33% - 99.88%Color and Shape:SolidMolecular weight:620.86Ref: TM-T6S1495
1mg85.00€5mg172.00€10mg255.00€25mg426.00€50mg630.00€100mg898.00€1mL*10mM (DMSO)283.00€IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Formula:C69H90F3N13O24Purity:98%Color and Shape:SoildMolecular weight:1542.54Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formula:C20H20O6Purity:100%Color and Shape:SolidMolecular weight:356.37Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormula:C21H23N3O3Purity:99.48%Color and Shape:SolidMolecular weight:365.43Flizasertib
CAS:Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Formula:C15H14FN3OPurity:100% - 99.39%Color and Shape:SolidMolecular weight:271.29Adelmidrol
CAS:Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Formula:C13H26N2O4Purity:99.35% - 99.73%Color and Shape:SolidMolecular weight:274.36Eudebeiolide B
CAS:Eudebeiolide B, isolated from Salvia plebeia R.Formula:C15H18O4Purity:98%Color and Shape:SolidMolecular weight:262.3Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormula:C15H15NO2SPurity:99.73%Color and Shape:SolidMolecular weight:273.35Ref: TM-T8705
1mg52.00€5mg116.00€10mg178.00€25mg340.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)107.00€BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formula:C19H21N7O2Purity:98%Color and Shape:SolidMolecular weight:379.42Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formula:C33H40O19Purity:98.78% - 99.13%Color and Shape:SolidMolecular weight:740.66IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67Usnoflast
CAS:Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.Formula:C21H29N3O3SPurity:98.79%Color and Shape:SolidMolecular weight:403.54AP-1/NF-κB activation inhibitor 1
CAS:AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basalFormula:C13H11F3N4O4Purity:100% - 99.74%Color and Shape:SolidMolecular weight:344.25Ref: TM-T9656
1mg73.00€2mg96.00€5mg160.00€10mg216.00€25mg354.00€50mg525.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)170.00€Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formula:C31H42N2O3Purity:100% - 98.69%Color and Shape:SolidMolecular weight:490.68Ref: TM-T15198
1mg99.00€2mg144.00€5mg235.00€10mg376.00€25mg677.00€50mg1,064.00€1mL*10mM (DMSO)254.00€HS271
CAS:HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formula:C21H24F3N5O2Purity:98.12%Color and Shape:SolidMolecular weight:435.44Ref: TM-T37082
1mg62.00€2mg89.00€5mg135.00€10mg212.00€25mg368.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)149.00€5-Aminosalicylic Acid
CAS:5-ASA, an anti-inflammatory salicylate, treats inflammatory bowel disease, active part of sulphalazine.Formula:C7H7NO3Purity:98.88% - 99.98%Color and Shape:Purplish-Tan Solid PowderMolecular weight:153.14Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purity:100% - 99.57%Color and Shape:SolidMolecular weight:542.49Ref: TM-T4S2326
1mg96.00€5mg264.00€10mg415.00€25mg677.00€50mg935.00€100mg1,254.00€500mg2,527.00€1mL*10mM (DMSO)315.00€Isoquercetin
CAS:1.Formula:C21H20O12Purity:98.08% - 99.29%Color and Shape:SolidMolecular weight:464.38Ref: TM-T5S0754
5mg49.00€10mg65.00€25mg97.00€50mg153.00€100mg221.00€200mg329.00€1mL*10mM (DMSO)50.00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formula:C26H30O13Purity:98.84% - 99.27%Color and Shape:SolidMolecular weight:550.51Tyloxapol
CAS:Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Formula:C70H124O13Purity:polymer - polymerColor and Shape:Clear Light Yellow Viscous LiquidMolecular weight:137.18Ref: TM-T6S1371
1mg52.00€5mg97.00€10mg140.00€25mg274.00€50mg411.00€100mg597.00€500mg1,225.00€1mL*10mM (DMSO)105.00€Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormula:C19H18NO4Purity:98.08% - 99.18%Color and Shape:SolidMolecular weight:324.35Theaflavin 3,3'-digallate
CAS:Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.7Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Color and Shape:SolidMolecular weight:459.50Eclitasertib
CAS:Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Formula:C19H18N6O3Purity:99.82%Color and Shape:SolidMolecular weight:378.38Ref: TM-T9702
1mg106.00€2mg150.00€5mg227.00€10mg359.00€25mg652.00€50mg905.00€100mg1,293.00€1mL*10mM (DMSO)250.00€BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg59.00€10mg97.00€25mg210.00€50mg343.00€100mg513.00€200mg740.00€500mg1,121.00€1mL*10mM (DMSO)88.00€CL075
CAS:CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFormula:C13H13N3SPurity:99.25%Color and Shape:SolidMolecular weight:243.33Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Formula:C36H49NO12Purity:98% - 99.84%Color and Shape:SolidMolecular weight:687.77Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formula:C21H22O11Purity:97.53% - 98.63%Color and Shape:SolidMolecular weight:450.39Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:100% - 99.78%Color and Shape:White PowderMolecular weight:947.15B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Purity:98%Color and Shape:SolidRIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formula:C26H25FN6O2Purity:98.7%Color and Shape:SolidMolecular weight:472.51Ref: TM-T63055
1mg205.00€5mg495.00€10mg677.00€25mg1,008.00€50mg1,349.00€100mg1,833.00€200mg2,452.00€1mL*10mM (DMSO)568.00€Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Formula:C21H20O13Purity:97.57% - 98.97%Color and Shape:SolidMolecular weight:480.38NLRP3-IN-10
CAS:NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Formula:C17H14BrFO3Purity:99.63%Color and Shape:SolidMolecular weight:365.19Ref: TM-T61392
5mg47.00€10mg70.00€25mg126.00€50mg187.00€100mg311.00€200mg465.00€1mL*10mM (DMSO)65.00€2,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFormula:C4H6N4OPurity:99.82%Color and Shape:White Solid CrystalsMolecular weight:126.12NLRP3-IN-11
CAS:NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Formula:C17H17ClN4O2Purity:100%Color and Shape:SolidMolecular weight:344.8GSK2983559 active metabolite
CAS:GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Formula:C21H22N4O4S2Purity:97.07% - 98.48%Color and Shape:SolidMolecular weight:458.55Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64
