IκB/IKK
The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.
Products of "IκB/IKK"
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BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formula:C14H18ClN5Purity:99.13%Color and Shape:SolidMolecular weight:291.78Ref: TM-T8542
1mg40.00€2mg52.00€5mg87.00€10mg126.00€25mg225.00€50mg376.00€100mg563.00€1mL*10mM (DMSO)55.00€AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Formula:C21H23N5O4SPurity:98.98% - 99.17%Color and Shape:SolidMolecular weight:441.5Ref: TM-T6771
1mg52.00€2mg70.00€5mg103.00€10mg160.00€25mg311.00€50mg502.00€100mg805.00€500mg1,605.00€1mL*10mM (DMSO)114.00€BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormula:C15H15NO2SPurity:99.73%Color and Shape:SolidMolecular weight:273.35Ref: TM-T8705
1mg52.00€5mg116.00€10mg178.00€25mg340.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)107.00€BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formula:C19H21N7O2Purity:98%Color and Shape:SolidMolecular weight:379.42Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Isophysalin A
CAS:Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) productionFormula:C28H30O10Purity:98%Color and Shape:SolidMolecular weight:526.532-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.Formula:C11H10N2OSPurity:99.48%Color and Shape:SolidMolecular weight:218.27IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurity:98.76% - 99.61%Color and Shape:SolidMolecular weight:483.63Ref: TM-T6176
1mg40.00€2mg52.00€5mg88.00€10mg139.00€25mg245.00€50mg406.00€100mg607.00€200mg845.00€1mL*10mM (DMSO)87.00€BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg59.00€10mg97.00€25mg210.00€50mg343.00€100mg513.00€200mg740.00€500mg1,121.00€1mL*10mM (DMSO)88.00€TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purity:98.89%Color and Shape:SolidMolecular weight:457.52Ref: TM-T15559
1mg92.00€5mg188.00€10mg305.00€25mg487.00€50mg660.00€100mg847.00€1mL*10mM (DMSO)188.00€HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurity:98.07%Color and Shape:SolidMolecular weight:401.87IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purity:98%Color and Shape:SolidMolecular weight:431.91(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormula:C31H30O8Purity:99.03%Color and Shape:SolidMolecular weight:530.57Ref: TM-T9105
1mg166.00€5mg341.00€10mg550.00€25mg898.00€50mg1,216.00€100mg1,644.00€1mL*10mM (DMSO)398.00€GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formula:C17H17BrF3N7O2SPurity:99.46% - ≥98%Color and Shape:SolidMolecular weight:520.33Ref: TM-T5540
1mg47.00€2mg59.00€5mg92.00€10mg131.00€25mg215.00€50mg378.00€100mg567.00€1mL*10mM (DMSO)96.00€HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.38BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97.00%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formula:C26H36N6O2Purity:99.25% - 99.79%Color and Shape:SolidMolecular weight:464.6IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Formula:C15H8BrF6NO2Purity:99.51%Color and Shape:SolidMolecular weight:428.12Goshonoside F5
CAS:Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.Formula:C32H54O13Purity:98%Color and Shape:SolidMolecular weight:646.771
