CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Products of "CCR"
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CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formula:C22H22ClN7O2Purity:99% - 99.28%Color and Shape:SolidMolecular weight:451.91RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Formula:C21H22ClF3N2O2Purity:98.95%Color and Shape:SolidMolecular weight:426.86MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Formula:C24H34F3N3O3Purity:98%Color and Shape:SolidMolecular weight:469.54NI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Color and Shape:LiquidMolecular weight:145.5Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Color and Shape:Odour SolidCCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Formula:C22H29NO3Color and Shape:SolidMolecular weight:355.47ML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Formula:C27H32N4O4SPurity:99.91%Color and Shape:SolidMolecular weight:508.63MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Formula:C28H40F3N3O7Purity:98.62%Color and Shape:SolidMolecular weight:587.63CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formula:C22H25F3N4O3SPurity:98.79%Color and Shape:SolidMolecular weight:482.52GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formula:C24H25ClN4O5S2Purity:99.78%Color and Shape:SolidMolecular weight:549.06Ref: TM-T11481
1mg38.00€5mg84.00€10mg125.00€25mg259.00€50mg375.00€100mg545.00€500mgTo inquire1mL*10mM (DMSO)93.00€Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Formula:C33H42N4O6Purity:98.14%Color and Shape:SolidMolecular weight:590.71CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormula:C21H21ClF3N3O2Purity:99.63%Color and Shape:SolidMolecular weight:439.86Ref: TM-T13114
1mg52.00€5mg120.00€10mg188.00€25mg329.00€50mg490.00€100mg697.00€1mL*10mM (DMSO)133.00€AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Formula:C26H34N4O2Purity:97.12%Color and Shape:SolidMolecular weight:434.57Ref: TM-T10425
1mg88.00€5mg170.00€10mg259.00€25mg429.00€50mg605.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)182.00€RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formula:C25H27N3O3Purity:98.49% - 98.64%Color and Shape:SolidMolecular weight:417.5CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Formula:C17H25FN2O2Purity:100%Color and Shape:SolidMolecular weight:308.39Ref: TM-T10712
1mg70.00€5mg156.00€10mg239.00€25mg419.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)170.00€CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formula:C35H47FN4O2Purity:98%Color and Shape:SolidMolecular weight:574.77Cenicriviroc Mesylate
CAS:Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.Formula:C42H56N4O7S2Purity:98%Color and Shape:SolidMolecular weight:793.05PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formula:C25H36F3N5O3Purity:98%Color and Shape:SolidMolecular weight:511.58AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFormula:C20H29ClFN5O2Purity:98%Color and Shape:SolidMolecular weight:425.93C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Formula:C27H41N5O2Purity:100.00% - 99.74%Color and Shape:SolidMolecular weight:467.65Ref: TM-T21870
1mg51.00€2mg71.00€5mg96.00€10mg153.00€25mg303.00€50mg469.00€100mg655.00€1mL*10mM (DMSO)96.00€
