CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Products of "CCR"
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AZD-5672
CAS:AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.Formula:C32H38F2N2O5S2Purity:95.58%Color and Shape:SolidMolecular weight:632.78Ref: TM-T30260
1mg202.00€5mg459.00€10mg643.00€25mg938.00€50mg1,311.00€100mg1,786.00€1mL*10mM (DMSO)560.00€C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formula:C27H43Cl2N5O2Purity:98.51%Color and Shape:SolidMolecular weight:540.57ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Formula:C21H28N2O3Purity:99.43%Color and Shape:SolidMolecular weight:356.46CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Formula:C21H23ClN4O3SPurity:98.40% - 99.26%Color and Shape:SolidMolecular weight:446.95Maraviroc
CAS:Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s-MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Formula:C29H41F2N5OPurity:100% - 99.55%Color and Shape:Brown SolidMolecular weight:513.67Ref: TM-T6016
5mg51.00€10mg95.00€25mg160.00€50mg273.00€100mg492.00€200mg633.00€500mg998.00€1mL*10mM (DMSO)59.00€7,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formula:C15H10O4Purity:99.39% - 99.6%Color and Shape:SolidMolecular weight:254.24CCR1 antagonist 8
CAS:CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).Formula:C22H18FN5O3SColor and Shape:SolidMolecular weight:451.47J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Formula:C30H37Cl2IN2O2Purity:98%Color and Shape:SolidMolecular weight:655.44Ref: TM-T11699
1mg59.00€2mg87.00€5mg126.00€10mg169.00€25mg304.00€50mg527.00€100mg758.00€1mL*10mM (DMSO)180.00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formula:C27H32Cl2N2O7Purity:99.01%Color and Shape:SolidMolecular weight:567.46R243
CAS:R243 is CCR8 signaling and chemotaxis inhibitor.Formula:C21H27NO4Purity:97.86%Color and Shape:SolidMolecular weight:357.44Ref: TM-T24700
1mg43.00€2mg56.00€5mg85.00€10mg124.00€25mg220.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)95.00€YM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Formula:C32H28N4O3Purity:98%Color and Shape:SolidMolecular weight:516.59CCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formula:C21H24ClN5O3SPurity:98%Color and Shape:SolidMolecular weight:461.96BMS-813160
CAS:BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Formula:C25H40N8O2Purity:99.66% - 99.78%Color and Shape:SolidMolecular weight:484.64Ref: TM-T4584
1mg63.00€5mg137.00€10mg187.00€25mg341.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)145.00€Cenicriviroc
CAS:Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Formula:C41H52N4O4SPurity:97.87%Color and Shape:SolidMolecular weight:696.94Ref: TM-TQ0297
1mg69.00€5mg149.00€10mg235.00€25mg470.00€50mg610.00€100mg793.00€200mg1,064.00€1mL*10mM (DMSO)221.00€BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formula:C28H34F3N5O4SPurity:99.05%Color and Shape:SolidMolecular weight:593.66Ref: TM-T14688
1mg58.00€5mg116.00€10mg183.00€25mg368.00€50mg562.00€100mg758.00€200mg1,017.00€1mL*10mM (DMSO)156.00€CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formula:C14H12N2SPurity:99.53%Color and Shape:SolidMolecular weight:240.32MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formula:C30H31ClN2O4Purity:98.62%Color and Shape:SolidMolecular weight:519.03IPG7236
CAS:IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormula:C23H31N3O3SPurity:98%Color and Shape:SolidMolecular weight:429.58Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidLanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidINCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Formula:C29H34F3N3O6Purity:98.00% - 98.2%Color and Shape:SolidMolecular weight:577.59Ref: TM-TQ0103
1mg70.00€5mg153.00€10mg243.00€25mg411.00€50mg610.00€100mg868.00€1mL*10mM (DMSO)188.00€PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Formula:C29H31F3N6O3Purity:98.85% - 99.47%Color and Shape:SolidMolecular weight:568.59BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Formula:C23H27N5O3SPurity:99.83%Color and Shape:SolidMolecular weight:453.56CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Formula:C20H13ClF3N5O3SPurity:97.58% - 99.95%Color and Shape:SolidMolecular weight:495.86Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Formula:C22H21ClN2O4SPurity:99.23%Color and Shape:SolidMolecular weight:444.93Ref: TM-T17225
1mg105.00€5mg259.00€10mg406.00€25mg680.00€50mg938.00€100mg1,301.00€500mg2,593.00€1mL*10mM (DMSO)363.00€CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Formula:C26H29N3O5SPurity:97.33%Color and Shape:SolidMolecular weight:495.59Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Formula:C32H42F3N5O6Purity:97.51% - 98.16%Color and Shape:SolidMolecular weight:649.7RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Formula:C20H16Cl2N4Purity:99.60% - 99.87%Color and Shape:SolidMolecular weight:383.27MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Formula:C32H32ClF3N2O6Purity:98.62%Color and Shape:SolidMolecular weight:633.05SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formula:C27H28N4O3Purity:98%Color and Shape:SolidMolecular weight:456.54SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Formula:C18H18N2O5Purity:99.59%Color and Shape:SolidMolecular weight:342.35AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Formula:C11H9Cl2N3O3SPurity:99.80% - 99.92%Color and Shape:SolidMolecular weight:334.18Ref: TM-T4300
1mg35.00€5mg70.00€10mg111.00€25mg230.00€50mg354.00€100mg530.00€500mg1,121.00€1mL*10mM (DMSO)78.00€CCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.Formula:C24H23F3N4O3SPurity:98.91%Color and Shape:SolidMolecular weight:504.52Ref: TM-T10715
1mg116.00€5mg283.00€10mg424.00€25mg682.00€50mg934.00€100mg1,301.00€500mg2,612.00€1mL*10mM (DMSO)311.00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purity:99.21%Color and Shape:SolidMolecular weight:531.13CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Formula:C28H32BrF3N2OColor and Shape:SolidMolecular weight:549.47BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Formula:C21H24ClFN4O3Purity:98% - 99.94%Color and Shape:SolidMolecular weight:434.89Ref: TM-T2375
1mg38.00€5mg90.00€10mg124.00€25mg212.00€50mg329.00€100mg515.00€200mg782.00€1mL*10mM (DMSO)90.00€DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Formula:C35H56N10O15Purity:100%Color and Shape:SolidMolecular weight:856.88Bindarit
CAS:Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.Formula:C19H20N2O3Purity:98.35% - 98.71%Color and Shape:SolidMolecular weight:324.37Ref: TM-T6413
1mg57.00€5mg123.00€10mg187.00€25mg315.00€50mg472.00€100mg677.00€500mg1,388.00€1mL*10mM (DMSO)137.00€CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formula:C19H21Cl2N3O4S2Purity:99.85%Color and Shape:SolidMolecular weight:490.42Ref: TM-T10156
1mg92.00€5mg188.00€10mg305.00€25mg489.00€50mg655.00€100mg883.00€1mL*10mM (DMSO)224.00€CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formula:C22H22ClN7O2Purity:99% - 99.28%Color and Shape:SolidMolecular weight:451.91RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Formula:C21H22ClF3N2O2Purity:98.95%Color and Shape:SolidMolecular weight:426.86MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Formula:C24H34F3N3O3Purity:98%Color and Shape:SolidMolecular weight:469.54NI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Color and Shape:LiquidMolecular weight:145.5Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Color and Shape:Odour SolidCCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Formula:C22H29NO3Color and Shape:SolidMolecular weight:355.47ML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Formula:C27H32N4O4SPurity:99.91%Color and Shape:SolidMolecular weight:508.63MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Formula:C28H40F3N3O7Purity:98.62%Color and Shape:SolidMolecular weight:587.63CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formula:C22H25F3N4O3SPurity:98.79%Color and Shape:SolidMolecular weight:482.52GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formula:C24H25ClN4O5S2Purity:99.78%Color and Shape:SolidMolecular weight:549.06Ref: TM-T11481
1mg38.00€5mg84.00€10mg125.00€25mg259.00€50mg375.00€100mg545.00€500mgTo inquire1mL*10mM (DMSO)93.00€
