CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Products of "CXCR"
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IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formula:C21H36Cl2N4S2Purity:98.03%Color and Shape:SolidMolecular weight:479.57Ref: TM-T11693L
1mg42.00€5mg89.00€10mg144.00€25mg283.00€50mg510.00€100mg740.00€500mg1,510.00€1mL*10mM (DMSO)88.00€SB-265610
CAS:SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formula:C14H9BrN6OPurity:97.67%Color and Shape:SolidMolecular weight:357.16Ref: TM-T16850
1mg56.00€5mg119.00€10mg187.00€25mg376.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)131.00€SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purity:98.03%Color and Shape:SolidMolecular weight:425.48NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurity:98.18%Color and Shape:SolidMolecular weight:395.54Ref: TM-T12269
1mg115.00€5mg274.00€10mg432.00€25mg772.00€50mg1,074.00€100mg1,444.00€200mg1,882.00€1mL*10mM (DMSO)283.00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purity:99.21%Color and Shape:SolidMolecular weight:531.13SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Formula:C27H28F2N6O3Purity:98.31%Color and Shape:SolidMolecular weight:522.55Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formula:C39H57N13O8S2·xC2HF3O2Molecular weight:900.08 (free base)AMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formula:C32H28F3N5O4Purity:99.89%Color and Shape:SolidMolecular weight:603.59Ref: TM-T10297L
1mg52.00€5mg115.00€10mg164.00€25mg263.00€50mg369.00€100mg587.00€200mg835.00€1mL*10mM (DMSO)154.00€Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formula:C14H21NO3SPurity:98% - 99.89%Color and Shape:SolidMolecular weight:283.39Ref: TM-T4163
1mg52.00€2mg79.00€5mg119.00€10mg187.00€25mg393.00€50mg587.00€100mg835.00€500mg1,663.00€1mL*10mM (DMSO)111.00€MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formula:C16H16N6Purity:97.02% - 98.78%Color and Shape:SolidMolecular weight:292.34Ref: TM-T3992
1mg35.00€5mg64.00€10mg97.00€25mg188.00€50mg311.00€100mg487.00€200mg682.00€1mL*10mM (DMSO)67.00€Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formula:C28H54N8Purity:100% - 99.81%Color and Shape:SolidMolecular weight:502.78LIT927
CAS:LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).Formula:C17H13ClN2O3Purity:99.57% - 99.73%Color and Shape:SolidMolecular weight:328.75MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Formula:C16H24N2O4Purity:98.43%Color and Shape:SolidMolecular weight:308.37CXCR7 antagonist-1
CAS:CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.Formula:C21H19FN6OPurity:99.51%Color and Shape:SolidMolecular weight:390.41CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formula:C19H20Cl2FN3O4SPurity:99.53%Color and Shape:SolidMolecular weight:476.35E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formula:C28H37ClF3N3O3Color and Shape:SolidMolecular weight:556.06VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formula:C31H39FN2O8Purity:97.98%Color and Shape:SolidMolecular weight:586.65Ref: TM-T13324
1mg43.00€2mg55.00€5mg88.00€10mg137.00€25mg273.00€50mg472.00€100mg680.00€200mg947.00€1mL*10mM (DMSO)97.00€CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Formula:C18H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:475.53
