CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Products of "CXCR"
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AZD-5069
CAS:AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formula:C18H22F2N4O5S2Purity:98.38% - 98.63%Color and Shape:SolidMolecular weight:476.52Ref: TM-T7681
1mg50.00€2mg65.00€5mg85.00€10mg124.00€25mg227.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)88.00€AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Formula:C19H25N5OS2Purity:98.73% - 99.68%Color and Shape:SolidMolecular weight:403.56Ref: TM-T14384
1mg90.00€5mg188.00€10mg354.00€25mg748.00€50mg938.00€100mg1,359.00€1mL*10mM (DMSO)216.00€ML339
CAS:ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.Formula:C26H32ClN3O5Purity:99.46%Color and Shape:SolidMolecular weight:502SCH 546738
CAS:SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Formula:C23H31Cl2N7OPurity:98.67%Color and Shape:SolidMolecular weight:492.45Danirixin
CAS:Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).Formula:C19H21ClFN3O4SPurity:100.00% - 99.78%Color and Shape:SolidMolecular weight:441.9SRT3109
CAS:SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formula:C18H23F2N5O4S2Purity:99.65% - 99.92%Color and Shape:SolidMolecular weight:475.53USL311
CAS:USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formula:C24H34N6OPurity:98.46% - 99.56%Color and Shape:SolidMolecular weight:422.57Ref: TM-T17208
1mg42.00€5mg88.00€10mg127.00€25mg250.00€50mg393.00€100mg628.00€500mg1,304.00€1mL*10mM (DMSO)87.00€UNBS5162
CAS:UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Formula:C17H18N4O3Purity:98.37% - 99.97%Color and Shape:SolidMolecular weight:326.35Ref: TM-T2477
1mg39.00€5mg81.00€10mg116.00€25mg215.00€50mg340.00€100mg540.00€200mg787.00€1mL*10mM (DMSO)89.00€ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Formula:C104H178N26O25S2Color and Shape:SolidMolecular weight:2256.82Nicotinamide N-oxide
CAS:Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formula:C6H6N2O2Purity:99.61% - 99.9%Color and Shape:SolidMolecular weight:138.12WZ811
CAS:WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).Formula:C18H18N4Purity:99.42% - ≥95%Color and Shape:SolidMolecular weight:290.36Plerixafor octahydrochloride
CAS:Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formula:C28H62Cl8N8Purity:98.01% - 99.79%Color and Shape:SolidMolecular weight:794.46AMD-070 hydrochloride
CAS:AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formula:C21H28ClN5Purity:98.38% - 98.57%Color and Shape:SolidMolecular weight:385.93(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColor and Shape:SolidMolecular weight:539.69JMS-17-2
CAS:JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formula:C25H26ClN3OPurity:98.70% - 99.44%Color and Shape:SolidMolecular weight:419.95Ref: TM-T5849
1mg40.00€2mg52.00€5mg87.00€10mg131.00€25mg221.00€50mg344.00€100mg512.00€1mL*10mM (DMSO)96.00€Mavorixafor
CAS:Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.Formula:C21H27N5Purity:98.56%Color and Shape:SolidMolecular weight:349.47Ref: TM-TQ0174
1mg70.00€2mg92.00€5mg153.00€10mg220.00€25mg396.00€50mg588.00€100mg835.00€1mL*10mM (DMSO)249.00€Burixafor hydrobromide
CAS:Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.Formula:C27H52BrN8O3PPurity:98%Color and Shape:SolidMolecular weight:647.644MSX-130
CAS:MSX-130 is CXCR4 Antagonist.Formula:C36H26N4Purity:99.19%Color and Shape:SolidMolecular weight:514.62Delmetacin
CAS:Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Formula:C18H15NO3Purity:99.42%Color and Shape:SolidMolecular weight:293.32IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formula:C21H36Cl2N4S2Purity:98.03%Color and Shape:SolidMolecular weight:479.57Ref: TM-T11693L
1mg42.00€5mg89.00€10mg144.00€25mg283.00€50mg510.00€100mg740.00€500mg1,510.00€1mL*10mM (DMSO)88.00€SB-265610
CAS:SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formula:C14H9BrN6OPurity:97.67%Color and Shape:SolidMolecular weight:357.16Ref: TM-T16850
1mg56.00€5mg119.00€10mg187.00€25mg376.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)131.00€SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purity:98.03%Color and Shape:SolidMolecular weight:425.48NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurity:98.18%Color and Shape:SolidMolecular weight:395.54Ref: TM-T12269
1mg115.00€5mg274.00€10mg432.00€25mg772.00€50mg1,074.00€100mg1,444.00€200mg1,882.00€1mL*10mM (DMSO)283.00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purity:99.21%Color and Shape:SolidMolecular weight:531.13SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Formula:C27H28F2N6O3Purity:98.31%Color and Shape:SolidMolecular weight:522.55Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formula:C39H57N13O8S2·xC2HF3O2Molecular weight:900.08 (free base)AMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formula:C32H28F3N5O4Purity:99.89%Color and Shape:SolidMolecular weight:603.59Ref: TM-T10297L
1mg52.00€5mg115.00€10mg164.00€25mg263.00€50mg369.00€100mg587.00€200mg835.00€1mL*10mM (DMSO)154.00€Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formula:C14H21NO3SPurity:98% - 99.89%Color and Shape:SolidMolecular weight:283.39Ref: TM-T4163
1mg52.00€2mg79.00€5mg119.00€10mg187.00€25mg393.00€50mg587.00€100mg835.00€500mg1,663.00€1mL*10mM (DMSO)111.00€MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formula:C16H16N6Purity:97.02% - 98.78%Color and Shape:SolidMolecular weight:292.34Ref: TM-T3992
1mg35.00€5mg64.00€10mg97.00€25mg188.00€50mg311.00€100mg487.00€200mg682.00€1mL*10mM (DMSO)67.00€Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formula:C28H54N8Purity:100% - 99.81%Color and Shape:SolidMolecular weight:502.78LIT927
CAS:LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).Formula:C17H13ClN2O3Purity:99.57% - 99.73%Color and Shape:SolidMolecular weight:328.75MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Formula:C16H24N2O4Purity:98.43%Color and Shape:SolidMolecular weight:308.37CXCR7 antagonist-1
CAS:CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.Formula:C21H19FN6OPurity:99.51%Color and Shape:SolidMolecular weight:390.41CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formula:C19H20Cl2FN3O4SPurity:99.53%Color and Shape:SolidMolecular weight:476.35E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formula:C28H37ClF3N3O3Color and Shape:SolidMolecular weight:556.06VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formula:C31H39FN2O8Purity:97.98%Color and Shape:SolidMolecular weight:586.65Ref: TM-T13324
1mg43.00€2mg55.00€5mg88.00€10mg137.00€25mg273.00€50mg472.00€100mg680.00€200mg947.00€1mL*10mM (DMSO)97.00€CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Formula:C18H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:475.53Pentixafor
CAS:Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFormula:C60H80N14O14Purity:98%Color and Shape:SolidMolecular weight:1221.36ITIC-4F
CAS:ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Formula:C94H78F4N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1499.92Navarixin
CAS:Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormula:C21H23N3O5Purity:98% - 98.63%Color and Shape:SolidMolecular weight:397.42Ref: TM-T7130
1mg40.00€5mg85.00€10mg120.00€25mg210.00€50mg316.00€100mg467.00€500mg1,026.00€1mL*10mM (DMSO)93.00€rac-NBI-74330
CAS:rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formula:C32H27F4N5O3Purity:97.85%Color and Shape:SolidMolecular weight:605.58SX-682
CAS:SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formula:C19H14BF4N3O4SPurity:98.19% - 99.57%Color and Shape:SolidMolecular weight:467.2SB225002
CAS:SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formula:C13H10BrN3O4Purity:98.16% - 98.79%Color and Shape:SolidMolecular weight:352.14Ref: TM-T1955
5mg50.00€10mg66.00€25mg127.00€50mg225.00€100mg404.00€200mg617.00€500mg938.00€1mL*10mM (DMSO)52.00€Reparixin L-lysine salt
CAS:Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Formula:C20H35N3O5SPurity:99%Color and Shape:SolidMolecular weight:429.57EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formula:C25H35N5Color and Shape:SolidMolecular weight:405.58CXCR4-IN-1
CAS:CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabeticFormula:C23H32N6Purity:98%Color and Shape:SolidMolecular weight:392.54VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.33
