TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Products of "TLR"
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Found 63 products on this category.
MD2-TLR4-IN-1
CAS:MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.Formula:C22H14Cl2N4OPurity:97.74%Color and Shape:SolidMolecular weight:421.28Ref: TM-T7672
1mg62.00€5mg135.00€10mg212.00€25mg363.00€50mg510.00€100mg672.00€200mg905.00€1mL*10mM (DMSO)149.00€TLR3-IN-1
CAS:TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.Formula:C18H13ClFNO3SPurity:98.56%Color and Shape:SolidMolecular weight:377.82Ref: TM-T22698
1mg52.00€2mg74.00€5mg114.00€10mg187.00€25mg398.00€50mg593.00€100mg845.00€500mg1,700.00€1mL*10mM (DMSO)126.00€MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate
CAS:MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Formula:C52H72N12O11Purity:97.70%Color and Shape:SolidMolecular weight:1041.2LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formula:C33H40O19Purity:98.78% - 99.13%Color and Shape:SolidMolecular weight:740.66Polyinosinic-polycytidylic acid
CAS:Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts as the most potent IFN inducer.Formula:(C10H13N4O8P)x·(C9H14N3O8P)xPurity:90%Color and Shape:SolidMolecular weight:671.4CL264
CAS:CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.Formula:C19H23N7O4Purity:97.14%Color and Shape:SolidMolecular weight:413.43Ref: TM-T10833
1mg51.00€5mg116.00€10mg192.00€25mg304.00€50mg420.00€100mg560.00€200mg755.00€1mL*10mM (DMSO)128.00€3M-011
CAS:3M-011: potent TLR7/8 agonist, cytokine inducer, enhances radiotherapy, fights H3N2, and has anti-tumor effects.Formula:C18H25N5O3SPurity:98%Color and Shape:SolidMolecular weight:391.49IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formula:C35H71NO5Purity:98.17%Color and Shape:SolidMolecular weight:585.94Bropirimine
CAS:Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.Formula:C10H8BrN3OPurity:99.01%Color and Shape:SolidMolecular weight:266.09TL8-506
CAS:TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.Formula:C20H17N3O2Purity:95%Color and Shape:SolidMolecular weight:331.37MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.Formula:C54H73F3N12O13Purity:99.67%Color and Shape:SolidMolecular weight:1155.22Ref: TM-T74468L
1mg201.00€5mg497.00€10mg701.00€25mg1,094.00€50mg1,508.00€100mg1,931.00€200mg2,637.00€BBIQ
CAS:BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1Formula:C21H22N4Purity:98.02%Color and Shape:SolidMolecular weight:330.43Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Formula:C28H34N4O2Purity:97.43% - 99.27%Color and Shape:SolidMolecular weight:458.6TLR7 agonist 3
CAS:TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.Formula:C18H24N4OPurity:99.27%Color and Shape:SolidMolecular weight:312.41Ref: TM-T38614
1mg115.00€5mg274.00€10mg455.00€25mg748.00€50mg1,064.00€100mg1,415.00€1mL*10mM (DMSO)303.00€VB 201
CAS:VB 201 is a small molecule of oxidized phospholipids with anti-inflammatory activity that can be used to study atherosclerosis.Formula:C29H60NO8PPurity:100%Color and Shape:SolidMolecular weight:581.76E6446 dihydrochloride
CAS:E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.Formula:C27H37Cl2N3O3Purity:98.44%Color and Shape:SolidMolecular weight:522.51Ref: TM-T4068
1mg107.00€2mg169.00€5mg304.00€10mg376.00€25mg628.00€50mg895.00€100mg1,216.00€200mg1,634.00€1V209
CAS:1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.Formula:C16H17N5O5Purity:99.61%Color and Shape:SolidMolecular weight:359.34Ref: TM-T8316
1mg38.00€5mg79.00€10mg126.00€25mg271.00€50mg395.00€100mg560.00€200mg797.00€1mL*10mM (DMSO)87.00€CU-CPT9b
CAS:CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).Formula:C16H13NO2Purity:98.10%Color and Shape:SolidMolecular weight:251.28Chloranil
CAS:Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Formula:C6Cl4O2Purity:99.38%Color and Shape:SolidMolecular weight:245.88CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formula:C19H22O7Purity:98.66%Color and Shape:SolidMolecular weight:362.37Ref: TM-T15020
1mg52.00€2mg70.00€5mg99.00€10mg168.00€25mg313.00€50mg469.00€100mg682.00€200mg938.00€1mL*10mM (DMSO)114.00€BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formula:C23H29N3Purity:99.85%Color and Shape:SoildMolecular weight:347.5SM-324405
CAS:SM-324405 is an agonist of TLR7.Formula:C19H23N5O4Purity:97.83%Color and Shape:SolidMolecular weight:385.42Ref: TM-T7860
1mg37.00€5mg78.00€10mg113.00€25mg202.00€50mg324.00€100mg462.00€200mg645.00€1mL*10mM (DMSO)87.00€AXC-715 trihydrochloride
CAS:AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.Formula:C18H28Cl3N5Purity:99.74%Color and Shape:SolidMolecular weight:420.81Gardiquimod
CAS:Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.Formula:C17H23N5OPurity:98.02% - 99.47%Color and Shape:SolidMolecular weight:313.4CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formula:C27H24N2O8Purity:98.49%Color and Shape:SolidMolecular weight:504.49Cholesterol oxidase
CAS:Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol. ChOx competitively inhibits TLR2 enhance ROS production by macrophages.Color and Shape:SolidE6446
CAS:E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling.Formula:C27H35N3O3Purity:98.72%Color and Shape:SolidMolecular weight:449.59Rabeximod
CAS:Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.Formula:C22H24ClN5OPurity:100%Color and Shape:SolidMolecular weight:409.91Tomaralimab
CAS:Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).Purity:> 95% - SDS-PAGE:95% SEC-HPLC:99.99%Color and Shape:LiquidMolecular weight:145.32 kDaTLR7/8 agonist 1 dihydrochloride
CAS:TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Formula:C22H27Cl2N5Purity:98.33%Color and Shape:SolidMolecular weight:432.39MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Formula:C20H22O6Purity:99.87%Color and Shape:SolidMolecular weight:358.39C29
CAS:C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.Formula:C16H15NO4Purity:96.34% - 97.37%Color and Shape:SolidMolecular weight:285.29TLR7 agonist 2
CAS:TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).Formula:C17H16N6O2Purity:99.33%Color and Shape:SolidMolecular weight:336.35Ref: TM-T4258
1mg157.00€2mg240.00€5mg495.00€10mg717.00€25mg1,111.00€50mg1,501.00€100mg2,023.00€1mL*10mM (DMSO)365.00€Desethyl chloroquine diphosphate
CAS:Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.Formula:C16H28ClN3O8P2Purity:99.72%Color and Shape:SolidMolecular weight:487.81TLR7/8-IN-1
CAS:TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.Formula:C29H40N8O2Purity:99.83%Color and Shape:SolidMolecular weight:532.68PF-4878691
CAS:PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.Formula:C17H23N5O2SPurity:98.43%Color and Shape:SolidMolecular weight:361.46Ref: TM-T16506
1mg48.00€5mg144.00€10mg235.00€25mg512.00€50mg847.00€100mg1,378.00€1mL*10mM (DMSO)159.00€TLR7/8/9-IN-1
CAS:TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.Formula:C27H37N3O2Purity:98.31%Color and Shape:SolidMolecular weight:435.6Ref: TM-T39669
1mg52.00€2mg73.00€5mg117.00€10mg188.00€25mg306.00€50mg449.00€100mg610.00€200mg872.00€1mL*10mM (DMSO)170.00€AN3485 Hydrochloride
CAS:AN3485 Hydrochloride is an anti-inflammatory agent and a TLRs inhibitor, reducing ear swelling induced by PMA.Formula:C14H14BCl2NO3Purity:99.76%Color and Shape:SolidMolecular weight:325.98ODN 1668
CAS:ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN), used as an agonist for TLR9, and upregulates the level of IgM.Color and Shape:SolidMolecular weight:6364.1CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Formula:C17H15NO2Purity:99.01%Color and Shape:SolidMolecular weight:265.31Ref: TM-T7317
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg236.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)87.00€Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Formula:C36H59N5O2Purity:98.61%Color and Shape:SolidMolecular weight:593.89Ref: TM-T17032
1mg172.00€2mg235.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)462.00€Procyanidin B1
CAS:Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Formula:C30H26O12Purity:98.00% - 99.13%Color and Shape:Red-Brown PowderMolecular weight:578.52Ref: TM-TQ0205
1mg51.00€5mg170.00€10mg274.00€25mg465.00€50mg652.00€100mg920.00€1mL*10mM (DMSO)221.00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Formula:C17H23N5OPurity:99.93%Color and Shape:SolidMolecular weight:313.4Ref: TM-T13167
1mg64.00€5mg140.00€10mg226.00€25mg368.00€50mg509.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)156.00€Afimetoran
CAS:Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.Formula:C26H32N6OPurity:99.89%Color and Shape:SolidMolecular weight:444.57Ref: TM-T39654
1mg92.00€5mg187.00€10mg311.00€25mg530.00€50mg748.00€100mg1,064.00€1mL*10mM (DMSO)215.00€Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Formula:C16H15F3N4Purity:97.08% - 99.38%Color and Shape:SolidMolecular weight:320.31CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Formula:C14H12N4OPurity:99.00%Color and Shape:SolidMolecular weight:252.27Ref: TM-T7347
1mg48.00€5mg88.00€10mg127.00€25mg224.00€50mg349.00€100mg528.00€200mg752.00€1mL*10mM (DMSO)106.00€AZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Formula:C29H43N7O5Color and Shape:SolidMolecular weight:569.7CU-115
CAS:CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.Formula:C21H11F7INO2Purity:100%Color and Shape:SolidMolecular weight:569.21ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFormula:C11H9BrClN3O4SPurity:99.15%Color and Shape:SolidMolecular weight:394.63Ref: TM-T39115
1mg123.00€5mg298.00€10mg472.00€25mg748.00€50mg1,026.00€100mg1,406.00€1mL*10mM (DMSO)328.00€SM-276001
CAS:SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.Formula:C16H21N7OPurity:99.37%Color and Shape:SolidMolecular weight:327.38Ref: TM-T12933
1mg64.00€5mg139.00€10mg202.00€25mg364.00€50mg547.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)153.00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Ref: TM-T15017
1mg106.00€2mg150.00€5mg216.00€10mg283.00€25mg356.00€50mg432.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)188.00€TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formula:C21H25N5OPurity:98%Color and Shape:SolidMolecular weight:363.46DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Formula:C19H28N8O2Purity:99.12%Color and Shape:SolidMolecular weight:400.48TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Semapimod tetrahydrochloride
CAS:Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.Formula:C34H56Cl4N18O2Purity:99.8%Color and Shape:SolidMolecular weight:890.74M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formula:C13H13Cl2N3OSPurity:96.85%Color and Shape:SolidMolecular weight:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formula:C23H31N3O3Purity:99.88%Color and Shape:SolidMolecular weight:397.51Ref: TM-T61882
1mg103.00€5mg246.00€10mg395.00€25mg785.00€50mg1,130.00€100mg1,768.00€200mg2,357.00€1mL*10mM (DMSO)271.00€TH1020
CAS:TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.Formula:C23H15N7S2Purity:99.23%Color and Shape:SolidMolecular weight:453.54SM360320
CAS:SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.Formula:C15H17N5O3Purity:98.4%Color and Shape:SolidMolecular weight:315.33Ref: TM-T19675
1mg116.00€5mg244.00€10mg364.00€25mg562.00€50mg780.00€100mg1,035.00€500mg2,100.00€1mL*10mM (DMSO)269.00€CU-CPD107
CAS:CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Formula:C16H21IN2O2Purity:98.86%Color and Shape:SolidMolecular weight:400.25
