STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Products of "STAT"
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Neocucurbitacin A
CAS:Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Formula:C31H42O8Purity:98%Color and Shape:SolidMolecular weight:542.66FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:96.39% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg46.00€5mg66.00€10mg93.00€25mg124.00€50mg197.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)72.00€Homoharringtonine
CAS:Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.Formula:C29H39NO9Purity:98.21% - 99.54%Color and Shape:Off-White CrystMolecular weight:545.62STAT6-IN-3
CAS:STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.Formula:C32H35IN3O7PPurity:98%Color and Shape:SolidMolecular weight:731.51W1131 TFA
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models ofPurity:98%Color and Shape:Odour SolidHO-3867
CAS:HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.Formula:C28H30F2N2O2Purity:91.18% - 99.21%Color and Shape:SolidMolecular weight:464.55STAT3-IN-39
CAS:STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Formula:C20H17F3N2O3SColor and Shape:SolidMolecular weight:422.42RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37STAT6-IN-2
CAS:STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.Formula:C28H31N5O2Purity:99.67%Color and Shape:SolidMolecular weight:469.58Fludarabine
CAS:Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.Formula:C10H12FN5O4Purity:100% - 99.88%Color and Shape:White SolidMolecular weight:285.23L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formula:C15H15NO5SPurity:98.59%Color and Shape:SolidMolecular weight:321.35inS3-54-A26
CAS:inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Formula:C25H19ClN2O2Purity:98.83%Color and Shape:SolidMolecular weight:414.88Ref: TM-T27613
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€500mgTo inquireSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formula:C16H15NO3SColor and Shape:SolidMolecular weight:301.36Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formula:C42H68O13Purity:98.34% - 99.73%Color and Shape:White PowderMolecular weight:780.98Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purity:100% - 99.74%Color and Shape:SolidMolecular weight:346.42Ref: TM-T4672
1mg96.00€5mg215.00€10mg369.00€25mg610.00€50mg840.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)235.00€STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formula:C25H27N5OColor and Shape:SolidMolecular weight:413.51TLC1566-0618
CAS:TLC1566-0618 shows antitumor activity and targets stat.Formula:C20H15NO3S3Purity:98%Color and Shape:SolidMolecular weight:413.53NSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formula:C21H25NO6Purity:96.16%Color and Shape:SolidMolecular weight:387.43Ref: TM-T9949
5mg70.00€10mg119.00€25mg250.00€50mg424.00€100mg627.00€500mg1,320.00€1mL*10mM (DMSO)77.00€Balsalazide
CAS:Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Formula:C17H15N3O6Purity:99.31%Color and Shape:Yellow To Orange Crystalline PowderMolecular weight:357.32STAT3-IN-1
CAS:STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumorFormula:C28H29NO6Purity:95.89% - 95.89%Color and Shape:SolidMolecular weight:475.53Ref: TM-T13009
1mg60.00€2mg88.00€5mg131.00€10mg192.00€25mg349.00€50mg523.00€100mg753.00€500mg1,549.00€1mL*10mM (DMSO)137.00€inS3-54A18
CAS:inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Formula:C23H16ClNO2Purity:99.54%Color and Shape:SolidMolecular weight:373.83Ref: TM-T15582
2mg42.00€5mg65.00€10mg93.00€25mg160.00€50mg226.00€100mg320.00€200mg452.00€1mL*10mM (DMSO)71.00€SH5-07
CAS:SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).Formula:C29H28F5N3O5SPurity:95.54%Color and Shape:SolidMolecular weight:625.61Ref: TM-TQ0052
1mg37.00€5mg80.00€10mg117.00€25mg197.00€50mg294.00€100mg425.00€200mg602.00€1mL*10mM (DMSO)99.00€STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formula:C19H16N2O4SColor and Shape:SolidMolecular weight:368.41BP-1-102
CAS:BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formula:C29H27F5N2O6SPurity:99.25% - 99.81%Color and Shape:SolidMolecular weight:626.59Ref: TM-T3708
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg210.00€50mg354.00€100mg522.00€1mL*10mM (DMSO)104.00€Colivelin
CAS:Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).Formula:C119H206N32O35Purity:96.56%Color and Shape:SolidMolecular weight:2645.1Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73WZ-2-033
CAS:WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Formula:C25H18F3N3O4SColor and Shape:SolidMolecular weight:513.49NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurity:98.06% - 99.72%Color and Shape:SolidMolecular weight:412.26MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purity:99.74%Color and Shape:SolidMolecular weight:252.27Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Formula:C12H9N3O5Purity:98.31% - 99.87%Color and Shape:Yellow SolidMolecular weight:275.22STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormula:C30H27F4N7SPurity:98%Color and Shape:SolidMolecular weight:593.64Scutellarin
CAS:Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.Formula:C21H18O12Purity:95.86% - 99.32%Color and Shape:SolidMolecular weight:462.36AS1810722
CAS:AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Formula:C25H25F2N7OPurity:99.13%Color and Shape:SolidMolecular weight:477.51Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.Formula:C20H18O6Purity:99.81%Color and Shape:Off White PowderMolecular weight:354.35STAT3 degrader-2
CAS:STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormula:C59H62N9O13PPurity:98%Color and Shape:SolidMolecular weight:1136.15Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Formula:C13H8Cl2N2O4Purity:96.83% - 98.9%Color and Shape:Pale Yellow Crystals SolidMolecular weight:327.12(R)-Lisofylline
CAS:(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Formula:C13H20N4O3Purity:99.50%Color and Shape:SolidMolecular weight:280.32C188-9
CAS:C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.Formula:C27H21NO5SPurity:100% - 99.19%Color and Shape:SolidMolecular weight:471.52Ref: TM-T4650
1mg46.00€2mg59.00€5mg87.00€10mg123.00€25mg250.00€50mg398.00€100mg593.00€500mg1,264.00€1mL*10mM (DMSO)96.00€STAT3-IN-B9
CAS:STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Formula:C20H13NO5SPurity:98.16%Color and Shape:SolidMolecular weight:379.39Ref: TM-T28865
1mg115.00€2mg162.00€5mg249.00€10mg369.00€25mg562.00€50mg787.00€100mg1,054.00€200mg1,406.00€1mL*10mM (DMSO)269.00€STAT3-IN-37
CAS:STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formula:C23H25Cl2N5O2Color and Shape:SolidMolecular weight:474.38Cryptotanshinone
CAS:Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.Formula:C19H20O3Purity:97.69% - ≥95%Color and Shape:Orange Needle CrystalMolecular weight:296.36STAT3-IN-8
CAS:"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."Formula:C19H7F7N2O3Purity:98%Color and Shape:SolidMolecular weight:444.26Golotimod (TFA) (229305-39-9 free base)
Golotimod (TFA), an immunomodulating peptide, boosts antituberculosis treatments and enhances immune cell growth and macrophage function.Formula:C18H20F3N3O7Purity:98%Color and Shape:SolidMolecular weight:447.36Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formula:C30H42O7Purity:96.69% - 98.2%Color and Shape:SolidMolecular weight:514.65Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 98.91%Color and Shape:SolidMolecular weight:383.82Pimozide
CAS:Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.Formula:C28H29F2N3OPurity:100% - 99.85%Color and Shape:SolidMolecular weight:461.55Garcinone D
CAS:Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).Formula:C24H28O7Purity:99.94%Color and Shape:SolidMolecular weight:428.47HJC0152 free base
CAS:HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFormula:C15H13Cl2N3O4Purity:98%Color and Shape:SolidMolecular weight:370.19Eupalinolide K
CAS:Eupalinolide K is a natural productFormula:C20H26O6Purity:98%Color and Shape:SolidMolecular weight:362.42Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formula:C40H52O4Purity:95.1% - 99.79%Color and Shape:Needles From Acetone/Light Petroleum SolidMolecular weight:596.84STAT3 HiBiT degrader 1
CAS:STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Formula:C58H63F4N10O14PSColor and Shape:SolidMolecular weight:1263.21Niclosamide olamine
CAS:Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.Formula:C15H15Cl2N3O5Purity:99.89%Color and Shape:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Molecular weight:388.2Ref: TM-T4S0145
1mg51.00€5mg96.00€10mg153.00€25mg249.00€50mg369.00€100mg545.00€500mg1,130.00€1mL*10mM (DMSO)145.00€2-(1,8-naphthyridin-2-yl)phenol
CAS:2-NP is a STAT1 enhancer.Formula:C14H10N2OPurity:99.33% - 99.82%Color and Shape:SolidMolecular weight:222.24Ref: TM-T2168
5mg60.00€10mg96.00€25mg187.00€50mg298.00€100mg469.00€200mg682.00€500mg1,035.00€1mL*10mM (DMSO)66.00€Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formula:C19H18O8Purity:98% - 99.57%Color and Shape:SolidMolecular weight:374.34Casticin
CAS:Casticin combats vascular inflammation by blocking ROS-NF-κB and could lead in prostate cancer treatment.Formula:C19H18O8Purity:99.37% - ≥95%Color and Shape:SolidMolecular weight:374.34STAT3-IN-36
CAS:STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Formula:C30H24F2N2O9S2Color and Shape:SolidMolecular weight:658.65Balsalazide disodium dihydrate
CAS:Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.Formula:C17H17N3Na2O8Purity:98.95% - 99.46%Color and Shape:Yellow To Orange Crystalline PowderMolecular weight:437.31STAT5-IN-1
CAS:STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Formula:C16H11N3O3Purity:99.44% - ≥95%Color and Shape:SolidMolecular weight:293.28Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.Formula:C22H22N2O4Color and Shape:SolidMolecular weight:378.42Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Formula:C30H26N2O2Color and Shape:SolidMolecular weight:446.54Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purity:98.21% - 99.85%Color and Shape:SolidMolecular weight:476.73Ref: TM-TN2346
1mg37.00€5mg74.00€10mg111.00€25mg180.00€50mg269.00€100mg399.00€500mg905.00€1mL*10mM (DMSO)79.00€SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Formula:C29H27F5N2O5SPurity:98% - 99.12%Color and Shape:SolidMolecular weight:610.59Ref: TM-T6669
1mg50.00€2mg66.00€5mg96.00€10mg160.00€25mg311.00€50mg502.00€100mg730.00€1mL*10mM (DMSO)135.00€Compound SC-1
CAS:SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Formula:C21H13ClF3N3O2Purity:99.41%Color and Shape:SolidMolecular weight:431.8Ref: TM-T22424
1mg90.00€5mg160.00€10mg245.00€25mg444.00€50mg638.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)178.00€Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formula:C26H24N2O11P2Purity:97.18%Color and Shape:SolidMolecular weight:602.42Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formula:C14H8O4Purity:98.43% - 99.61%Color and Shape:SolidMolecular weight:240.21Angoline
CAS:Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.Formula:C22H21NO5Purity:99.43% - 99.96%Color and Shape:SolidMolecular weight:379.41Ref: TM-TN6739
1mg66.00€5mg144.00€10mg207.00€25mg344.00€50mg512.00€100mg740.00€1mL*10mM (DMSO)158.00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Formula:C7H5N3O2Purity:99.45% - 99.95%Color and Shape:Off-White To Yellow SolidMolecular weight:163.13Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Formula:C23H29ClO4Purity:98%Color and Shape:SolidMolecular weight:404.93Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formula:C27H42O3Purity:98.87% - 99.87%Color and Shape:Flaky Or Needle CrystalMolecular weight:414.62ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formula:C15H15ClN2O4Purity:99.35%Color and Shape:SolidMolecular weight:322.74Ref: TM-T35544
1mg95.00€5mg227.00€10mg359.00€25mg630.00€50mg882.00€100mg1,188.00€200mg1,596.00€500mg2,357.00€1mL*10mM (DMSO)251.00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Formula:C22H14N4O3Purity:99.42%Color and Shape:SolidMolecular weight:382.37Ref: TM-T60160
5mg64.00€10mg92.00€25mg177.00€50mg283.00€100mg425.00€500mgTo inquire1mL*10mM (DMSO)64.00€HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formula:C15H14Cl3N3O4Purity:98.33% - 98.62%Color and Shape:SolidMolecular weight:406.64STAT3-IN-35
CAS:STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purity:99.53% - 99.91%Color and Shape:White Crystalline PowderMolecular weight:384.42TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFormula:C12H10FN3O2SPurity:95.03% - 97.86%Color and Shape:SolidMolecular weight:279.29Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Formula:C28H26N2O12P2Purity:98.97%Color and Shape:SolidMolecular weight:644.46Ref: TM-T9646
1mg208.00€5mg518.00€10mg740.00€25mg1,093.00€50mg1,473.00€100mg2,015.00€1mL*10mM (DMSO)737.00€AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurity:100%Color and Shape:SolidMolecular weight:405.24Ref: TM-T8378
1mg131.00€2mg180.00€5mg274.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€1mL*10mM (DMSO)303.00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98.85% - ≥98%Color and Shape:SolidMolecular weight:373.21Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purity:97.55% - 99.83%Color and Shape:SolidMolecular weight:230.3KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Formula:C60H74ClN10O14PSPurity:98.12%Color and Shape:SolidMolecular weight:1257.78Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFormula:C25H28O6Purity:99.94% - ≥98%Color and Shape:SolidMolecular weight:424.49PMMB-187
CAS:PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Formula:C27H23BrN2O6S2Color and Shape:SolidMolecular weight:615.52Stafia-1
CAS:Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Formula:C24H27O10PPurity:98.08%Color and Shape:SolidMolecular weight:506.44Ref: TM-T9339
1mg86.00€5mg187.00€10mg309.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)217.00€Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:100% - 99.42%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg87.00€5mg216.00€10mg354.00€25mg582.00€50mg825.00€100mg1,111.00€1mL*10mM (DMSO)197.00€UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Formula:C26H35NO5Purity:97%Color and Shape:SolidMolecular weight:441.56Ref: TM-T13950
1mg78.00€5mg169.00€10mg264.00€25mg528.00€50mg810.00€100mg1,169.00€200mg1,568.00€1mL*10mM (DMSO)178.00€Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45Antitumor agent-73
CAS:Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Formula:C50H82BrO4PPurity:98%Color and Shape:SolidMolecular weight:858.06Picroside I
CAS:Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Formula:C24H28O11Purity:99.70%Color and Shape:SolidMolecular weight:492.47SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8S3I-201
CAS:S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Formula:C16H15NO7SPurity:97.83%Color and Shape:SolidMolecular weight:365.36BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurity:99.02%Color and Shape:SolidMolecular weight:271.34Stattic
CAS:Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.Formula:C8H5NO4SPurity:98.54% - 99.76%Color and Shape:SolidMolecular weight:211.19Ref: TM-T6308
5mg35.00€10mg51.00€25mg85.00€50mg124.00€100mg187.00€200mg279.00€500mg465.00€1mL*10mM (DMSO)55.00€WP1066
CAS:WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formula:C17H14BrN3OPurity:98.92% - 99.73%Color and Shape:SolidMolecular weight:356.22SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Ref: TM-T8719
1mg46.00€5mg93.00€10mg140.00€25mg240.00€50mg363.00€100mg452.00€200mg630.00€1mL*10mM (DMSO)99.00€AS1517499
CAS:AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nMFormula:C20H20ClN5O2Purity:98.27% - 98.7%Color and Shape:SolidMolecular weight:397.86Ref: TM-T4476
1mg40.00€2mg52.00€5mg88.00€10mg119.00€25mg235.00€50mg376.00€100mg469.00€500mg1,064.00€1mL*10mM (DMSO)87.00€
