Pim
Pim kinases are a family of serine/threonine kinases that play a key role in cell survival, proliferation, and apoptosis. These kinases are downstream effectors in the JAK/STAT signaling pathway and are involved in various physiological processes, including immune responses and hematopoiesis. Overexpression of Pim kinases has been associated with the development of cancer, making them important targets for therapeutic intervention. At CymitQuimica, we offer a variety of high-quality Pim kinase inhibitors and modulators to support your research in oncology, cell biology, and signal transduction.
Products of "Pim"
Sort by
Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formula:C22H13Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:406.26TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formula:C22H25F3N4OPurity:97.72% - 99.95%Color and Shape:SolidMolecular weight:418.46PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purity:98%Color and Shape:SolidMolecular weight:474.56HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.Formula:C15H15N5O2SPurity:95.04%Color and Shape:SolidMolecular weight:329.38Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formula:C14H17N3O3Purity:99.81%Color and Shape:SoildMolecular weight:275.3Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Color and Shape:Odour SolidSMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31Ref: TM-T3989
1mg35.00€2mg48.00€5mg70.00€10mg87.00€25mg160.00€50mg235.00€100mg354.00€1mL*10mM (DMSO)92.00€TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formula:C18H11BrN2O2Purity:97% - 99.64%Color and Shape:SolidMolecular weight:367.2Ref: TM-T2253
1mg35.00€5mg64.00€10mg88.00€25mg187.00€50mg284.00€100mg424.00€200mg612.00€1mL*10mM (DMSO)97.00€TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formula:C11H6F3NO2SPurity:99.89%Color and Shape:SolidMolecular weight:273.23PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formula:C27H25BrCl2CuN6OPurity:98%Color and Shape:SolidMolecular weight:663.88PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formula:C19H22N4O2Purity:98%Color and Shape:SolidMolecular weight:338.4AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48Ref: TM-T2300
2mg38.00€5mg51.00€10mg74.00€25mg118.00€50mg213.00€100mg378.00€200mg495.00€500mg792.00€1mL*10mM (DMSO)57.00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formula:C17H11ClN4OPurity:98.81%Color and Shape:SolidMolecular weight:322.75GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurity:98%Color and Shape:SolidMolecular weight:416.48AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formula:C18H23N3O3SPurity:99.49%Color and Shape:SolidMolecular weight:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formula:C22H28ClN5O3Purity:98.30%Color and Shape:SolidMolecular weight:445.94HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formula:C14H11NO2Purity:99.55%Color and Shape:SolidMolecular weight:225.24Ref: TM-T9583
1mg35.00€5mg80.00€10mg116.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)77.00€Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurity:99.89%Color and Shape:SolidMolecular weight:235.26SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:100% - 99.84%Color and Shape:SolidMolecular weight:405.42GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Formula:C20H22F3N7OSColor and Shape:SolidMolecular weight:465.5
