JAK
JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.
Products of "JAK"
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NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formula:C32H34F3N7O2Color and Shape:SolidMolecular weight:605.65Itacitinib
CAS:Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formula:C26H23F4N9OPurity:96.4% - 99.01%Color and Shape:SolidMolecular weight:553.51Ref: TM-T3998
1mg49.00€2mg71.00€5mg111.00€10mg180.00€25mg325.00€50mg543.00€100mg780.00€500mg1,549.00€1mL*10mM (DMSO)137.00€WHI-P97
CAS:WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formula:C16H13Br2N3O3Purity:99.93%Color and Shape:SolidMolecular weight:455.1Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C25H24FN7O4Purity:99.74% - 99.82%Color and Shape:SolidMolecular weight:505.5Ref: TM-T12266L
1mg64.00€5mg138.00€10mg187.00€25mg273.00€50mg393.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)153.00€Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39Ref: TM-T78207
1mg52.00€5mg116.00€10mg178.00€25mg359.00€50mg533.00€100mg750.00€200mg1,064.00€1mL*10mM (DMSO)127.00€JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formula:C20H15ClF3N3OSColor and Shape:SolidMolecular weight:437.87Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formula:C24H28N8O2Purity:98.06% - 99.94%Color and Shape:SolidMolecular weight:460.53Ref: TM-T14331
1mg42.00€5mg88.00€10mg123.00€25mg188.00€50mg350.00€100mg522.00€200mg750.00€1mL*10mM (DMSO)116.00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurity:97% - 98.03%Color and Shape:SolidMolecular weight:372.46Ref: TM-T21503
1mg46.00€2mg59.00€5mg87.00€10mg119.00€25mg210.00€50mg349.00€100mg507.00€1mL*10mM (DMSO)96.00€Momelotinib sulfate
CAS:Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C23H26N6O10S2Purity:98%Color and Shape:SolidMolecular weight:610.62JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormula:C26H27N7O3Purity:98%Color and Shape:SolidMolecular weight:485.54JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formula:C18H15FN4O3Purity:98.61% - 99.81%Color and Shape:SolidMolecular weight:354.34Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Formula:C22H23N5O2Purity:99.61% - 99.82%Color and Shape:SolidMolecular weight:389.45JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formula:C17H14ClN5O2Purity:98%Color and Shape:SolidMolecular weight:355.78JAK3/BTK-IN-1
CAS:JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormula:C25H28N8OPurity:97.89%Color and Shape:SolidMolecular weight:456.54Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurity:100% - 99.91%Color and Shape:SolidMolecular weight:404.36Ref: TM-T3043
1g615.00€5mg52.00€10mg65.00€25mg82.00€50mg97.00€100mg145.00€200mg227.00€500mg418.00€1mL*10mM (DMSO)59.00€AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formula:C18H16F2N6Purity:96.02% - 98.51%Color and Shape:SolidMolecular weight:354.36Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purity:100% - 99.43%Color and Shape:SolidMolecular weight:425.46Ref: TM-T14687
1mg70.00€5mg153.00€10mg274.00€25mg432.00€50mg638.00€100mg908.00€200mg1,225.00€500mg1,825.00€1mL*10mM (DMSO)166.00€(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide；AG 490
CAS:Formula:C17H14N2O3Purity:98%Color and Shape:SolidMolecular weight:294.3047
