MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Formula:C8H9Cl2NO3Purity:98.1%Color and Shape:SoildMolecular weight:238.07Ref: TM-T10809L
1mg56.00€5mg116.00€10mg168.00€25mg269.00€50mg383.00€100mg510.00€200mg692.00€1mL*10mM (DMSO)101.00€SB 202190 hydrochloride
CAS:SB 202190 hydrochloride is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor ,differentiation to cardiomyocytes.Formula:C20H15ClFN3OPurity:99.99%Color and Shape:SolidMolecular weight:367.8Ref: TM-T35592
2mg49.00€5mg66.00€10mg90.00€25mg145.00€50mg207.00€100mg309.00€200mg459.00€1mL*10mM (DMSO)71.00€Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurity:98%Color and Shape:SolidMolecular weight:430.46Lupalbigenin
CAS:Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.Formula:C25H26O5Purity:98%Color and Shape:SolidMolecular weight:406.47Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purity:95.77% - 98.60%Color and Shape:SolidMolecular weight:462.89ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurity:99.77%Color and Shape:SoildMolecular weight:337.8Ref: TM-T77734
1mg86.00€2mg111.00€5mg180.00€10mg279.00€25mg562.00€50mg917.00€100mg1,454.00€500mg2,822.00€Farrerol
CAS:Farrerol shows antioxidative effects, modulates genes, fights S. aureus in cows, protects cells, and may prevent heart disease.Formula:C17H16O5Purity:99.89% - 99.96%Color and Shape:SolidMolecular weight:300.31Ref: TM-T6S0525
2mg43.00€5mg59.00€10mg85.00€25mg120.00€50mg170.00€100mg253.00€200mg375.00€1mL*10mM (DMSO)71.00€B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:98.59% - 99.56%Color and Shape:SolidMolecular weight:409.46Gardenin A
CAS:Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.Formula:C21H22O9Purity:95.15% - 95.15%Color and Shape:SolidMolecular weight:418.39Ref: TM-TN4114
1mg187.00€5mg467.00€10mg693.00€25mg1,074.00€50mg1,454.00€100mg1,882.00€500mg3,924.00€1mL*10mM (DMSO)502.00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formula:C9H10O2SPurity:99.48%Color and Shape:SolidMolecular weight:182.24Ref: TM-T8870
1mg51.00€5mg153.00€10mg207.00€25mg288.00€50mg404.00€100mg562.00€200mg758.00€1mL*10mM (DMSO)101.00€p38-α MAPK-IN-10
CAS:p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.Formula:C27H34Cl2N6Color and Shape:SolidMolecular weight:513.505Corylifol C
CAS:Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factorFormula:C20H18O5Purity:98%Color and Shape:SolidMolecular weight:338.35SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formula:C29H34F3N5O2Color and Shape:SolidMolecular weight:541.61JWG-071
CAS:JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formula:C34H44N8O3Purity:98.33%Color and Shape:SolidMolecular weight:612.77Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purity:97.98%Color and Shape:SolidMolecular weight:425.91Ref: TM-T9407
1mg40.00€5mg80.00€10mg116.00€25mg205.00€50mg340.00€100mg485.00€200mg655.00€1mL*10mM (DMSO)88.00€DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Formula:C17H15N5O2Purity:98.2% - 98.91%Color and Shape:SolidMolecular weight:321.33Laxiflorin B-4
Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].Purity:98%Color and Shape:Odour SolidPS-166276
CAS:PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Formula:C20H30N8OColor and Shape:SolidMolecular weight:398.51NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formula:C21H21N5O2Purity:97.04% - 99.46%Color and Shape:SolidMolecular weight:375.42LJI308
CAS:LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Formula:C21H18F2N2O2Purity:98.86% - 99.73%Color and Shape:SolidMolecular weight:368.38Omtriptolide
CAS:Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.Formula:C24H28O9Purity:98%Color and Shape:SolidMolecular weight:460.479p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Formula:C14H7F6N3OPurity:99.79%Color and Shape:SolidMolecular weight:347.215AZD7624
CAS:AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.Formula:C27H30FN5O3Purity:99.37%Color and Shape:SolidMolecular weight:491.56Ref: TM-T14381
1mg73.00€5mg160.00€10mg250.00€25mg507.00€50mg737.00€100mg1,026.00€1mL*10mM (DMSO)170.00€MK2-IN-3
CAS:MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.Formula:C21H16N4OPurity:99.01%Color and Shape:SolidMolecular weight:340.38Ref: TM-T9034
1mg39.00€5mg84.00€10mg120.00€25mg255.00€50mg375.00€100mg535.00€200mg728.00€1mL*10mM (DMSO)87.00€OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Formula:C49H77F3N10O16Purity:98%Color and Shape:SolidMolecular weight:1119.19KRAS inhibitor-32
CAS:KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formula:C29H35FN10OS2Color and Shape:SolidMolecular weight:622.78Rupestonic acid
CAS:Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for the treatment of colds.Formula:C15H20O3Purity:98.07%Color and Shape:SolidMolecular weight:248.32PF-4708671
CAS:PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).Formula:C19H21F3N6Purity:99.48% - 99.67%Color and Shape:SolidMolecular weight:390.41Glycinexylidide
CAS:Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting sodium channels with complexFormula:C10H14N2OPurity:98%Color and Shape:SolidMolecular weight:178.23Enniatin B
CAS:Enniatins B decreases the activation of ERK (p44/p42).Formula:C33H57N3O9Purity:98%Color and Shape:SolidMolecular weight:639.831Lyoniresinol
CAS:Lyoniresinol, a lignan from Tarenna attenuata, has antioxidant and anti-melanogenic properties, with an IC50 of 82.4 μM; tastes bitter.Formula:C22H28O8Purity:98%Color and Shape:SolidMolecular weight:420.45MBP MAPK Substrate acetate
MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.Formula:C41H74N18O13Purity:99.71%Color and Shape:SolidMolecular weight:1026.56827Ref: TM-T38796L
1mg158.00€2mg212.00€5mg300.00€10mg434.00€25mg658.00€50mg905.00€100mg1,206.00€200mg1,634.00€Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Formula:C22H26N2O4Purity:98.61% - 99.73%Color and Shape:SolidMolecular weight:382.45Meranzin hydrate
CAS:Meranzin hydrate acts as an antidepressant and aids digestion, targeting α2-adrenoceptors and AMPA receptors, hastened by BDNF and ERK1/2 modulation.Formula:C15H18O5Purity:99.49%Color and Shape:SolidMolecular weight:278.3Chrysoeriol
CAS:Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selectiveFormula:C16H12O6Purity:97.32%Color and Shape:SolidMolecular weight:300.26Ref: TM-TN1490
1mg48.00€5mg111.00€10mg180.00€25mg359.00€50mg532.00€100mg757.00€1mL*10mM (DMSO)120.00€Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Formula:C32H35ClFN7O2Purity:99.10% - 99.9%Color and Shape:SolidMolecular weight:604.12Rubrofusarin gentiobioside
CAS:Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) decreases the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity.Formula:C27H32O15Purity:99.75% - 99.91%Color and Shape:SolidMolecular weight:596.53Ref: TM-TN2165
1mg54.00€5mg115.00€10mg168.00€25mg284.00€50mg411.00€100mgTo inquire1mL*10mM (DMSO)170.00€LUNA18
CAS:LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation.Formula:C73H105F5N12O12Purity:98%Color and Shape:SolidMolecular weight:1437.68magnolin
CAS:Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.Formula:C23H28O7Purity:98% - 99.77%Color and Shape:SolidMolecular weight:416.46TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurity:98% - 98.92%Color and Shape:SolidMolecular weight:554.52AS601245.2TFA (345987-15-7 free base)
CAS:AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formula:C24H18F6N6O4SPurity:98%Color and Shape:SoildMolecular weight:600.50AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFormula:C29H28ClN5OPurity:98%Color and Shape:SolidMolecular weight:498.02J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurity:99.90%Color and Shape:SolidMolecular weight:373.794-(3,4-Dimethoxyphenyl)-3-buten-1-ol
CAS:'E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol could boost melanin synthesis through USF1 to treat hypopigmentation.'Formula:C12H16O3Purity:98%Color and Shape:SolidMolecular weight:208.25LY-364947
CAS:LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.Formula:C17H12N4Purity:99.41% - 99.96%Color and Shape:SolidMolecular weight:272.3Ref: TM-T2048
5mg65.00€10mg82.00€25mg143.00€50mg255.00€100mg374.00€200mg560.00€500mg877.00€1mL*10mM (DMSO)72.00€M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purity:98.95%Color and Shape:SolidMolecular weight:589.61LY-2584702 tosylate salt
CAS:LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.Formula:C28H27F4N7O3SPurity:98.5% - 98.51%Color and Shape:SolidMolecular weight:617.62Ref: TM-T1746
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg216.00€50mg359.00€100mg512.00€500mg1,093.00€1mL*10mM (DMSO)96.00€B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41BSc5367
CAS:BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase.cell cycle regulation, DNA repair, and microtubule regulation. ALS, PKD.Formula:C20H15N3O2Purity:98.72%Molecular weight:329.35Ref: TM-T201389
1mg97.00€5mg170.00€10mg269.00€25mg565.00€50mg877.00€100mg1,366.00€1mL*10mM (DMSO)185.00€methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.Formula:C13H13NO5Purity:97.69%Color and Shape:SolidMolecular weight:263.25LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formula:C27H33ClN2O4Purity:98.18%Color and Shape:SolidMolecular weight:485.01NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47MHJ-627
MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leadingFormula:C34H45BrN2O3Purity:98%Color and Shape:SolidMolecular weight:609.64Anti-ERK2 Antibody (4F551)
Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.Color and Shape:Odour LiquidPLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurity:97.78% - 99.83%Color and Shape:SolidMolecular weight:413.83PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purity:97.79% - 97.90%Color and Shape:SolidMolecular weight:477.3Ref: TM-T1974
1mg46.00€5mg94.00€10mg144.00€25mg255.00€50mg406.00€100mg628.00€500mg1,320.00€1mL*10mM (DMSO)97.00€MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formula:C37H41N9O3SPurity:96.15% - 99.89%Color and Shape:SolidMolecular weight:691.84Ref: TM-T12069
1mg81.00€5mg156.00€10mg271.00€25mg620.00€50mg938.00€100mg1,454.00€1mL*10mM (DMSO)230.00€CAY10404
CAS:CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.Formula:C17H12F3NO3SPurity:99.02%Color and Shape:SolidMolecular weight:367.34Ref: TM-T8656
2mg35.00€5mg52.00€10mg96.00€25mg177.00€50mg304.00€100mg437.00€200mg615.00€1mL*10mM (DMSO)58.00€BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurity:97.58%Color and Shape:SolidMolecular weight:313.74SGX-523
CAS:SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Formula:C18H13N7SPurity:100% - 99.49%Color and Shape:SolidMolecular weight:359.41JNK-IN-14
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.Formula:C27H31N5O4SPurity:98%Color and Shape:SolidMolecular weight:521.63BI-2493
CAS:BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.Formula:C24H27N7OSPurity:97.03% - 99.51%Color and Shape:SoildMolecular weight:461.58Jolkinolide B
CAS:Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud.Formula:C20H26O4Purity:99.39% - 99.7%Color and Shape:SolidMolecular weight:330.42Effusanin A
CAS:Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at 3.02 μM.Formula:C20H28O5Purity:98.00%Color and Shape:SolidMolecular weight:348.43Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formula:C21H16Cl2F4N4O3Purity:99.56%Color and Shape:SolidMolecular weight:519.28pan-KRAS degrader 1
CAS:Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Formula:C22H26N8OSColor and Shape:SolidMolecular weight:450.56Deltonin
CAS:Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formula:C45H72O17Purity:99.79%Color and Shape:SolidMolecular weight:885.04Galangin
CAS:Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.Formula:C15H10O5Purity:98.24% - 99.93%Color and Shape:Yellowish Needle-Like CrystalMolecular weight:270.24ERK5-IN-2
CAS:ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.Formula:C17H11BrFN3O2Purity:99.01%Color and Shape:SolidMolecular weight:388.19Ref: TM-T5535
1mg48.00€5mg96.00€10mg169.00€25mg283.00€50mg424.00€100mg612.00€200mg842.00€1mL*10mM (DMSO)111.00€CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurity:99.53% - ≥95%Color and Shape:SolidMolecular weight:424.93Anti-ERK2 Antibody (9C922)
Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.Color and Shape:Odour LiquidSB220025
CAS:SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.Formula:C18H19FN6Purity:99.44%Color and Shape:SolidMolecular weight:338.38JNK-1-IN-3
JNK-1-IN-3 (Compound 9e) acts as a JNK1 inhibitor, both reducing JNK1 gene expression and lowering the protein levels of its phosphorylated form. It concurrently diminishes the expression of downstream targets c-Jun and c-Fos in tumors, while also restoring p53 activity. Exhibiting broad-spectrum antiproliferative effects, JNK-1-IN-3 is particularly effective against renal and breast cancer cell lines, showing significant anticancer activity both in vivo and in vitro.Formula:C19H17FN4O3Color and Shape:SolidMolecular weight:368.362,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purity:99.75%Color and Shape:Yellow PowderMolecular weight:152.15Losmapimod
CAS:Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).Formula:C22H26FN3O2Purity:98.56% - 99.05%Color and Shape:SolidMolecular weight:383.46Ref: TM-T2277
2mg35.00€5mg52.00€10mg78.00€25mg139.00€50mg225.00€100mg406.00€500mg920.00€1mL*10mM (DMSO)55.00€Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purity:97.73% - 98.80%Color and Shape:SolidMolecular weight:527.66Ref: TM-T6277
1g562.00€5mg37.00€10mg55.00€25mg79.00€50mg92.00€100mg127.00€200mg225.00€500mg379.00€1mL*10mM (DMSO)44.00€BIX02189
CAS:BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formula:C27H28N4O2Purity:98% - 99.86%Color and Shape:SolidMolecular weight:440.54Ref: TM-T2416
1mg40.00€2mg52.00€5mg87.00€10mg123.00€25mg221.00€50mg378.00€100mg648.00€200mg904.00€500mg1,320.00€1mL*10mM (DMSO)96.00€Manassantin A
CAS:Manassantin A: potent HIF-1 inhibitor, guards stomach lining, curbs iNOS/NF-κB, may help treat airway diseases, reduces melanin by affecting MITF/tyrosinase.Formula:C42H52O11Purity:98%Color and Shape:SolidMolecular weight:732.867SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formula:C28H27F3N6O2Purity:98.32%Color and Shape:SolidMolecular weight:536.548Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFormula:C63H68F5N7O9SPurity:98%Color and Shape:SolidMolecular weight:1194.31Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purity:100% - 99%Color and Shape:SolidMolecular weight:441.23MC 976
CAS:MC 976 is a derivative of Vitamin D3.Formula:C27H42O3Purity:98%Color and Shape:SolidMolecular weight:414.63KRas G12C inhibitor 2
CAS:KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Formula:C32H37N7O3Purity:98%Color and Shape:SolidMolecular weight:567.68Cimiside E
CAS:Cimiside E tamps inflammation, halts gastric cancer growth, and triggers cell death by modulating PPAR-γ, ERK1/2, PI3K, and PKC pathways.Formula:C35H54O8Purity:98%Color and Shape:SolidMolecular weight:602.809TA-02
CAS:TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.Formula:C20H13F2N3Purity:99.35% - 99.79%Color and Shape:SolidMolecular weight:333.33Ref: TM-T4646
5mg39.00€10mg58.00€25mg104.00€50mg160.00€100mg244.00€500mgTo inquire1mL*10mM (DMSO)43.00€(S)-BAY-293
CAS:(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.Formula:C25H28N4O2SPurity:98%Color and Shape:SolidMolecular weight:448.58Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purity:98.21% - 99.85%Color and Shape:SolidMolecular weight:476.73Ref: TM-TN2346
1mg37.00€5mg74.00€10mg111.00€25mg180.00€50mg269.00€100mg399.00€500mg905.00€1mL*10mM (DMSO)79.00€ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formula:C26H24FNO5Purity:97.75%Color and Shape:SoildMolecular weight:449.47Ref: TM-T85316
1mg49.00€5mg92.00€10mg131.00€25mg212.00€50mg373.00€100mg635.00€200mg1,035.00€1mL*10mM (DMSO)110.00€MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Formula:C26H26N4O2Purity:97.48%Color and Shape:SolidMolecular weight:426.51KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:590.09Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formula:C22H21F3N4O4SPurity:99.85%Color and Shape:SolidMolecular weight:494.49Ref: TM-T63333
1mg95.00€5mg202.00€10mg298.00€25mg630.00€50mg948.00€100mg1,644.00€500mg3,307.00€1mL*10mM (DMSO)224.00€AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Formula:C10H5N3O3Purity:97.35%Color and Shape:SolidMolecular weight:215.16KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formula:C25H19ClF2N4O3SPurity:98.31%Color and Shape:SolidMolecular weight:528.96Talmapimod hydrochloride
CAS:Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.Formula:C27H31Cl2FN4O3Purity:98%Color and Shape:SolidMolecular weight:549.46CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formula:C22H21F3N6O2Purity:99.42%Color and Shape:SolidMolecular weight:458.44Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Ref: TM-T1792
5mg35.00€10mg51.00€25mg80.00€50mg96.00€100mg144.00€200mg185.00€500mg309.00€1mL*10mM (DMSO)57.00€Exarafenib
CAS:Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.Formula:C26H34F3N5O3Purity:98.36% - 99.39%Color and Shape:SolidMolecular weight:521.58Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purity:100% - 99.85%Color and Shape:SolidMolecular weight:272.25Ref: TM-T6427
1mg43.00€2mg56.00€5mg88.00€10mg106.00€25mg213.00€50mg344.00€100mg550.00€1mL*10mM (DMSO)87.00€2-Aminooctadecane-1,3,4-Triol
CAS:2-Aminooctadecane-1,3,4-Triol (Phytosphingosine) is a natural product.Formula:C18H39NO3Purity:≥98%Color and Shape:SolidMolecular weight:317.51(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Formula:C25H24N4O2Purity:97.39% - 98.38%Color and Shape:SolidMolecular weight:412.48Ref: TM-T6324
1mg50.00€2mg66.00€5mg126.00€10mg229.00€25mg344.00€50mg517.00€100mg745.00€1mL*10mM (DMSO)143.00€
