MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.Formula:C55H95N19O13Purity:96.63%Color and Shape:SolidMolecular weight:1230.46D-JNKI-1
CAS:D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44KS-58
CAS:KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Formula:C64H89FN12O14S2Color and Shape:SolidMolecular weight:1333.59ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purity:98.59%Color and Shape:SoildMolecular weight:339.43CK1δ-IN-9
CAS:CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.Formula:C16H12FN5Color and Shape:SolidMolecular weight:293.298JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formula:C13H7ClN4SPurity:98.74%Color and Shape:SolidMolecular weight:286.74Nothofagin
CAS:Nothofagin: Antioxidant, anti-inflammatory, prevents clotting, inhibits leukocyte activity, may treat vascular inflammation.Formula:C21H24O10Purity:99.21%Color and Shape:SolidMolecular weight:436.41Ref: TM-TN1996
1mg279.00€5mg620.00€10mg843.00€25mg1,264.00€50mg1,663.00€100mg2,262.00€1mL*10mM (DMSO)702.00€JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52Rosin
CAS:Rosin is a natural product,may have therapeutic potential for the treatment of inflammationFormula:C15H20O6Purity:99.75% - 99.85%Color and Shape:SolidMolecular weight:296.32SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurity:99.50% - 99.81%Color and Shape:SolidMolecular weight:490.56Ref: TM-T16927
1mg52.00€5mg103.00€10mg160.00€25mg304.00€50mg550.00€100mg882.00€500mg1,768.00€1mL*10mM (DMSO)114.00€PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purity:99.75%Color and Shape:SolidMolecular weight:476.23Ref: TM-T21980
1mg64.00€5mg138.00€10mg188.00€25mg330.00€50mg472.00€100mg655.00€500mg1,293.00€1mL*10mM (DMSO)160.00€CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Formula:C22H20FNO2Purity:99.67%Color and Shape:SolidMolecular weight:349.4Ref: TM-T14988
1mg37.00€5mg104.00€10mg160.00€25mg281.00€50mg442.00€100mg685.00€500mg1,605.00€1mL*10mM (DMSO)114.00€Licochalcone D
CAS:Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Formula:C21H22O5Purity:99.03% - 99.9%Color and Shape:SolidMolecular weight:354.4KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formula:C32H36ClN7O2Purity:98%Color and Shape:SolidMolecular weight:586.13SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Formula:C10H5ClN4O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:328.69Ref: TM-T22115
5mg47.00€10mg74.00€25mg135.00€50mg188.00€100mg283.00€200mg411.00€1mL*10mM (DMSO)50.00€DL-Sulforaphane N-acetyl-L-cysteine
CAS:DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formula:C11H20N2O4S3Color and Shape:SolidMolecular weight:340.48NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Formula:C29H30F3N5O2Purity:97.59% - ≥95%Color and Shape:SolidMolecular weight:537.58Ref: TM-T5643
1mg87.00€5mg160.00€10mg250.00€25mg502.00€50mg715.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)185.00€DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurity:100%Color and Shape:SolidMolecular weight:301.41TH-Z827
CAS:TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Formula:C30H38N6OPurity:98%Color and Shape:SolidMolecular weight:498.66Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Color and Shape:Odour SolidNardosinone
CAS:Nardosinone inhibits H9c2 cell hypertrophy, protects neurons from OGD, and boosts neurite outgrowth by modifying key signaling pathways.Formula:C15H22O3Purity:98.82% - 99%Color and Shape:SolidMolecular weight:250.33BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurity:97.95% - 98.27%Color and Shape:SolidMolecular weight:456.47Ref: TM-T10599
1mg47.00€5mg93.00€10mg144.00€25mg250.00€50mg393.00€100mg560.00€200mg812.00€1mL*10mM (DMSO)104.00€Bufarenogin
CAS:Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toadFormula:C24H32O6Purity:98.77%Color and Shape:SolidMolecular weight:416.51Lonafarnib
CAS:Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).Formula:C27H31Br2ClN4O2Purity:98% - 99.04%Color and Shape:SolidMolecular weight:638.82SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:98.43%Color and Shape:SolidMolecular weight:451.6Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Formula:C29H32ClF4N7O2Purity:98.79%Color and Shape:SolidMolecular weight:622.06Taspine
CAS:Taspine inhibits tumor growth, induces HUVEC apoptosis, moderates EGFR, Erk1/2, and Akt pathways, and promotes healing with an ED50 of 0.375 mg/kg.Formula:C20H19NO6Purity:98%Color and Shape:SolidMolecular weight:369.37TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purity:99.3%Color and Shape:SolidMolecular weight:531.51Ref: TM-T9693
1mg48.00€5mg97.00€10mg156.00€25mg271.00€50mg408.00€100mg567.00€200mg748.00€1mL*10mM (DMSO)113.00€Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formula:C5H6N2OSPurity:100% - 99.89%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18p38α inhibitor 3
CAS:p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.Formula:C19H20FNOPurity:99.93%Color and Shape:SoildMolecular weight:297.37KRAS inhibitor-35
CAS:KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Formula:C38H32F4N6O3SColor and Shape:SolidMolecular weight:728.76pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63Isomerazin
CAS:Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERKFormula:C15H16O4Purity:99.8%Color and Shape:SolidMolecular weight:260.29Methylnissolin
CAS:Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.Formula:C17H16O5Purity:99.68% - 99.98%Color and Shape:SolidMolecular weight:300.31ERK1/2 inhibitor 2
CAS:ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.Formula:C29H31ClFN5O5Purity:98.99%Color and Shape:SolidMolecular weight:584.04Aurantiamide
CAS:Aurantiamide inhibits cancer, inflammation, pain, and neuroinflammation by blocking autophagy and NF-κB, JNK, p38 pathways.Formula:C25H26N2O3Purity:98.88%Color and Shape:SolidMolecular weight:402.49Ref: TM-T5814
1mg137.00€5mg329.00€10mg490.00€25mg782.00€50mg1,035.00€100mg1,415.00€1mL*10mM (DMSO)469.00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Formula:C50H62N14O6S2Purity:99.24%Color and Shape:SolidMolecular weight:1019.25KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Formula:C24H20ClF2N3O3Purity:98%Color and Shape:SolidMolecular weight:471.88AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07%Color and Shape:SolidMolecular weight:485.58Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purity:98.15% - 98.25%Color and Shape:SolidMolecular weight:431.2Ref: TM-T6131
2mg37.00€5mg49.00€10mg62.00€25mg92.00€50mg147.00€100mg220.00€200mg285.00€1mL*10mM (DMSO)55.00€PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Formula:C16H13BrF3IN2O4Purity:99.81%Color and Shape:SolidMolecular weight:561.09Casein kinase 1δ-IN-27
CAS:Casein kinase1δ-IN-27 (Compound 8) is an inhibitor of casein kinase 1 (CK1), effectively inhibiting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22, 16.5, 9.41, and 14.8 nM, respectively. It also suppresses DUX4 expression, with an IC50 of 10 nM.Formula:C21H19FN6Color and Shape:SolidMolecular weight:374.414Lucidenic acid D
CAS:Lucidenic acid D2 is a nartural product from G. lucidum AF.Formula:C29H38O8Purity:98%Color and Shape:SolidMolecular weight:514.61Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purity:98.11% - 98.87%Color and Shape:SolidMolecular weight:578.52APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Formula:C23H16F8N4O3Purity:99.39%Color and Shape:SolidMolecular weight:548.39Ref: TM-T8843
2mg39.00€5mg88.00€10mg127.00€25mg250.00€50mg401.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)97.00€HS220
CAS:HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.Formula:C18H17N3O3Purity:99.98%Color and Shape:SoildMolecular weight:323.35Ref: TM-T60011
1mg49.00€5mg110.00€10mg170.00€25mg280.00€50mg373.00€100mg510.00€200mg700.00€1mL*10mM (DMSO)116.00€Nedometinib
CAS:Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Formula:C17H16FIN4O3Purity:99.18%Color and Shape:SolidMolecular weight:470.24Ref: TM-T78209
1mg74.00€5mg159.00€10mg226.00€25mg373.00€50mg593.00€100mg785.00€200mg1,035.00€1mL*10mM (DMSO)165.00€S6K-18
CAS:S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.Formula:C17H18N4O3SPurity:98.99%Color and Shape:SolidMolecular weight:358.41Desoxo-narchinol A
CAS:Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activityFormula:C12H16O2Purity:98%Color and Shape:SolidMolecular weight:192.25PF-06260933
CAS:PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.Formula:C16H13ClN4Purity:99.63% - 99.97%Color and Shape:SolidMolecular weight:296.75Ref: TM-T4221
1mg49.00€2mg64.00€5mg103.00€10mg163.00€25mg324.00€50mg520.00€100mg750.00€1mL*10mM (DMSO)103.00€PAF (C16)
CAS:PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.Formula:C26H54NO7PPurity:98%Color and Shape:SolidMolecular weight:523.68QL-X-138 HCl
QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.Formula:C25H20ClN5O2Purity:98.89%Color and Shape:SoildMolecular weight:457.91Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Formula:C14H15NO3Purity:97.13%Color and Shape:SolidMolecular weight:245.27PRT062607 hydrochloride
CAS:PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.Formula:C19H23N9O·HClPurity:97.11% - 99.93%Color and Shape:SolidMolecular weight:429.91Ref: TM-T2696
1mg60.00€2mg86.00€5mg127.00€10mg187.00€25mg326.00€50mg500.00€200mg948.00€1mL*10mM (DMSO)139.00€Bisabolangelone
CAS:Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.Formula:C15H20O3Purity:98.91%Color and Shape:SolidMolecular weight:248.3215-Methoxypinusolidic acid
CAS:15-Methoxypinusolidic acid: anti-inflammatory, inhibits iNOS/NO, affects MAPK/NF-kappaB, stops adipogenesis and glutamate toxicity, induces apoptosis.Formula:C21H30O5Purity:98%Color and Shape:SolidMolecular weight:362.46Agerafenib
CAS:Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formula:C24H22F3N5O5Purity:95.78% - 99.23%Color and Shape:SolidMolecular weight:517.46Ref: TM-T2070
1mg42.00€5mg87.00€10mg131.00€25mg230.00€50mg378.00€100mg560.00€200mg800.00€1mL*10mM (DMSO)96.00€BAY-6035
CAS:BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.Formula:C22H28N4O3Purity:99.39%Color and Shape:SolidMolecular weight:396.48Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purity:97.02% - 99.94%Color and Shape:White PowderMolecular weight:434.35Ref: TM-T6S0117
1mg58.00€5mg97.00€10mg160.00€25mg283.00€50mg418.00€100mg615.00€200mg878.00€1mL*10mM (DMSO)111.00€Pan-RAS-IN-1
CAS:Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Formula:C36H41Cl2F3N6O2Purity:98.57%Color and Shape:SolidMolecular weight:717.65Ref: TM-T16432
1mg80.00€2mg97.00€5mg144.00€10mg216.00€25mg439.00€50mg660.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)221.00€6-Acetonyldihydrochelerythrine
CAS:6-Acetonyldihydrochelerythrine: anti-HIV, antioxidant, induces apoptosis, cytotoxic to HCT116/SW620 cells, more effective than 5-FU. EC50=1.77µg/mL, TI=14.6.Formula:C24H23NO5Purity:98%Color and Shape:SolidMolecular weight:405.44Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurity:99.09% - 99.53%Color and Shape:SolidMolecular weight:340.42Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurity:99.72%Color and Shape:SolidMolecular weight:319.38Ref: TM-T67942
1mg81.00€5mg170.00€10mg259.00€25mg419.00€50mg562.00€100mg770.00€200mg1,035.00€1mL*10mM (DMSO)271.00€GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Formula:C31H28F3N7O3S2Purity:99%Color and Shape:SolidMolecular weight:667.72Ref: TM-T27454
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formula:C14H8O5Color and Shape:SolidMolecular weight:256.216,4'-Dihydroxy-7-methoxyflavanone
CAS:Active compound from Dalbergia odorifera with antioxidant, anti-inflammatory, neuroprotective properties, may treat bone diseases.Formula:C16H14O5Purity:98%Color and Shape:SolidMolecular weight:286.28KRAS inhibitor-8
CAS:KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Formula:C26H24ClF4N5O3Purity:98%Color and Shape:SolidMolecular weight:565.95A-674563
CAS:A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.Formula:C22H22N4OPurity:99.21%Color and Shape:SolidMolecular weight:358.44KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Formula:C32H37N7O2Purity:98%Color and Shape:SolidMolecular weight:551.68PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formula:C17H13BrClF2IN2O2Purity:99.40%Color and Shape:SolidMolecular weight:557.56Ref: TM-T21635
1mg38.00€2mg52.00€5mg79.00€10mg126.00€25mg273.00€50mg454.00€100mg653.00€200mg938.00€500mg1,406.00€KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Formula:C18H17ClFN3O4SPurity:98%Color and Shape:SolidMolecular weight:425.86Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Formula:C23H16ClFN6OSPurity:99.44% - ≥98%Color and Shape:SolidMolecular weight:478.93SJ-C1044
CAS:SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.Formula:C25H14F7N7OColor and Shape:SolidMolecular weight:561.41ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purity:98.82%Color and Shape:SolidMolecular weight:281.35AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23p38 Kinase inhibitor 7
CAS:p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Formula:C22H25FN6OColor and Shape:SolidMolecular weight:408.472B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formula:C20H17F2N5O4SPurity:98.2%Color and Shape:SolidMolecular weight:461.44Nisin Z
CAS:Nisin Z has anti-inflammatory activity and reduces the release of pro-inflammatory cytokines.Formula:C141H229N41O38S7Color and Shape:SolidMolecular weight:3331.03Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurity:98.53% - 99.36%Color and Shape:SolidMolecular weight:489.92RMM-46
CAS:RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.Formula:C24H26N4O5Purity:98.89%Color and Shape:SolidMolecular weight:450.495,6,7-TRIMETHOXYFLAVONE
CAS:5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.Formula:C18H16O5Purity:99.05% - 99.11%Color and Shape:SolidMolecular weight:312.32SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurity:95.65%Color and Shape:SolidMolecular weight:520.55BAY885
CAS:BAY885 is a new ERK5 inhibitor.Formula:C25H28F3N7O2Purity:99.83%Color and Shape:SolidMolecular weight:515.53Lup-20(29)-en-28-oic acid
CAS:Lup-20(29)-en-28-oic acid: Anticancer, blocks autophagy, boosts chemotherapeutics in HeLa cells. Pulsatilla saponin D: Has haemolytic activity.Formula:C47H76O17Purity:98%Color and Shape:SolidMolecular weight:913.1Nek2-IN-5
CAS:Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).Formula:C15H12N6OPurity:98.11%Color and Shape:SolidMolecular weight:292.3Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purity:97.00%Color and Shape:SolidMolecular weight:344.4Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Formula:C20H24O5Purity:98%Color and Shape:SolidMolecular weight:344.4Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purity:100% - 99.91%Color and Shape:White PowderMolecular weight:528.76Necrosulfonamide
CAS:(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis.Formula:C18H15N5O6S2Purity:98.85% - 99.49%Color and Shape:SolidMolecular weight:461.47p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formula:C16H13FN2OS2Purity:97.79%Color and Shape:SolidMolecular weight:332.42Maohuoside A
CAS:Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.Formula:C27H32O12Purity:98.91% - 98.95%Color and Shape:SolidMolecular weight:548.54Ref: TM-TN2081
1mg90.00€5mg197.00€10mg294.00€25mg469.00€50mg620.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)245.00€pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formula:C36H34F2N6O3Purity:98%Color and Shape:SolidMolecular weight:636.69Tenuifoliside A
CAS:Tenuifoliside A has anti-apoptotic , neuroprotective activity.Formula:C31H38O17Purity:98.99% - 99.91%Color and Shape:SolidMolecular weight:682.62KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Formula:C31H38N6O3Purity:98%Color and Shape:SolidMolecular weight:542.67Brimarafenib
CAS:Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Formula:C24H17F3N4O4Purity:98.32%Color and Shape:SolidMolecular weight:482.41ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Formula:C19H19NO3Purity:99.06% - 99.52%Color and Shape:SolidMolecular weight:309.36Ref: TM-T4619
1mg39.00€2mg49.00€5mg70.00€10mg99.00€25mg200.00€50mg283.00€100mg394.00€500mg934.00€1mL*10mM (DMSO)88.00€Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFormula:C31H26ClF4N7O2Purity:100% - 100%Color and Shape:SolidMolecular weight:640.03A-674563 2HCl(552325-73-2(fb-2hcl))
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.Formula:C22H24Cl2N4OPurity:94.66%Color and Shape:SolidMolecular weight:431.36Ref: TM-T6139L
1mg86.00€5mg138.00€10mg188.00€25mg335.00€50mg505.00€100mg730.00€1mL*10mM (DMSO)170.00€ERK-IN-4
CAS:ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Formula:C14H17ClN2O3SPurity:98.92% - 99.84%Color and Shape:SolidMolecular weight:328.814Ref: TM-T36675
1mg48.00€2mg60.00€5mg87.00€10mg144.00€25mg230.00€50mg341.00€100mg510.00€1mL*10mM (DMSO)104.00€
