MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Formula:C23H29FN6OPurity:96.96% - ≥95%Color and Shape:SolidMolecular weight:424.51RMC-9805
CAS:KRAS G12D inhibitor 18 is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formula:C63H88F3N11O7Purity:98.45% - 99.27%Color and Shape:SolidMolecular weight:1168.44Ref: TM-T78212
1mg130.00€5mg311.00€10mg533.00€25mg1,216.00€50mg2,005.00€100mg3,202.00€1mL*10mM (DMSO)687.00€JNK-1-IN-2
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values ofFormula:C16H20BrN5OPurity:98%Color and Shape:SolidMolecular weight:378.27Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Formula:C23H20F3N5O2S2Purity:100% - 99.83%Color and Shape:SolidMolecular weight:519.56KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Formula:C110H186N44O27S2Purity:98.94%Color and Shape:SolidMolecular weight:2621.06EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formula:C14H18ClN3O3Purity:97.61%Color and Shape:SolidMolecular weight:311.762-Hydroxy-3-methylanthraquinone
CAS:2-Hydroxy-3-methylanthraquinone triggers U937 cell apoptosis via p-p38MAPK, downregulates p-ERK1/2, and activates caspase-3.Formula:C15H10O3Purity:98%Color and Shape:SolidMolecular weight:238.24Hirsutenone
CAS:Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipidFormula:C19H20O5Purity:98%Color and Shape:SolidMolecular weight:328.36KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Formula:C24H21ClFN3O3Purity:100%Color and Shape:SolidMolecular weight:453.89Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purity:99.45% - 99.62%Color and Shape:SolidMolecular weight:615.67RMC-6291
CAS:RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.Formula:C55H78FN9O8Purity:98.73%Color and Shape:SolidMolecular weight:1012.26RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Formula:C28H29F3N4O4Purity:99.43% - 99.83%Color and Shape:SolidMolecular weight:542.55Ref: TM-T3711
1mg40.00€2mg52.00€5mg87.00€10mg131.00€25mg259.00€50mg424.00€100mg625.00€500mg1,311.00€1mL*10mM (DMSO)94.00€MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Formula:C24H20N4O4Purity:98%Color and Shape:SolidMolecular weight:428.44SB 242235
CAS:SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.Formula:C19H20FN5OPurity:99.13% - 99.68%Color and Shape:SolidMolecular weight:353.39MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purity:99.58%Color and Shape:SolidMolecular weight:358.39Ref: TM-T12058
1mg35.00€5mg64.00€10mg93.00€25mg180.00€50mg264.00€100mg369.00€200mg507.00€1mL*10mM (DMSO)78.00€SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formula:C5H3N5O2S3Purity:98.39%Color and Shape:SolidMolecular weight:261.3Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formula:C20H20O6Purity:100%Color and Shape:SolidMolecular weight:356.377,8-Didehydrocimigenol
CAS:7,8-Didehydrocimigenol treats cardiovascular issues by upregulating PPAR-γ, inhibiting NF-kB, and reducing VCAM-1 in EC.Formula:C30H46O5Purity:98%Color and Shape:SolidMolecular weight:486.693SD 0006
CAS:SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.Formula:C20H20ClN5O2Purity:98.32%Color and Shape:SolidMolecular weight:397.86Ref: TM-T7276
2mg38.00€5mg58.00€10mg90.00€25mg145.00€50mg226.00€100mg338.00€200mg472.00€1mL*10mM (DMSO)65.00€Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01CCT241161
CAS:CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.Formula:C28H27N7O3SPurity:100% - 98.48%Color and Shape:SolidMolecular weight:541.62BI-2865
CAS:BI-2865 is a non-covalent pan-KRAS inhibitor.Cost-effective and quality-assured.Formula:C23H27N7O2SPurity:99.19% - 99.39%Color and Shape:SoildMolecular weight:465.57Ref: TM-T72062
1mg216.00€5mg547.00€10mg660.00€25mg979.00€50mg1,293.00€100mg1,758.00€1mL*10mM (DMSO)550.00€Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.42KRAS G12C inhibitor 13
CAS:KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Formula:C40H46F3N7O4Purity:98%Color and Shape:SolidMolecular weight:745.83Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formula:C25H23N5O2SPurity:95.21% - 99.92%Color and Shape:SolidMolecular weight:457.55Ref: TM-T2675
1g2,080.00€2g2,802.00€2mg46.00€5mg66.00€10mg99.00€25mg162.00€50mg197.00€100mg350.00€500mg1,149.00€EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurity:98.47%Color and Shape:SolidMolecular weight:311.33Ref: TM-T27242
1g1,510.00€1mg40.00€5mg85.00€10mg133.00€25mg235.00€50mg354.00€100mg533.00€500mg1,130.00€1mL*10mM (DMSO)93.00€Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25Refametinib R enantiomer
CAS:Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be usedFormula:C19H20F3IN2O5SPurity:99.43%Color and Shape:SolidMolecular weight:572.34BCI-215
CAS:BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signalingFormula:C22H22BrNOPurity:99.40%Color and Shape:SolidMolecular weight:396.32RMC-7977
CAS:RMC-7977 is a inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.Formula:C47H60N8O6SPurity:97.46% - 99.7%Color and Shape:SolidMolecular weight:865.09Ref: TM-T81263
1mg245.00€5mg612.00€10mg938.00€25mg1,454.00€50mg1,882.00€100mg2,650.00€1mL*10mM (DMSO)937.00€AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Formula:C29H29Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:534.48Zabofloxacin hydrochloride
CAS:Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.Formula:C19H21ClFN5O4Purity:98%Color and Shape:SolidMolecular weight:437.86Cyclorasin 9A5
CAS:Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibitionFormula:C75H108FN25O13Purity:98%Color and Shape:SolidMolecular weight:1586.82Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Formula:C16H12O7Purity:92.82% - 99.20%Color and Shape:SolidMolecular weight:316.26Ref: TM-T2836
1mg40.00€5mg82.00€10mg119.00€25mg235.00€50mg393.00€100mg560.00€500mg1,206.00€1mL*10mM (DMSO)86.00€Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurity:98.64% - 99.74%Color and Shape:SolidMolecular weight:540.01Allicin
CAS:Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelialFormula:C6H10OS2Purity:≥98%Color and Shape:Clear To Slightly Yellow LiquidMolecular weight:162.27D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.Formula:C166H290N66O42Purity:99.48%Color and Shape:SolidMolecular weight:3882.5Ref: TM-T10937L
1mg164.00€5mg313.00€10mg467.00€25mg745.00€50mg1,064.00€100mg1,406.00€1mL*10mM (DMSO)1,149.00€EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Formula:C18H15F2IN2O5Purity:98%Color and Shape:SolidMolecular weight:504.22Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purity:100% - 99.57%Color and Shape:SolidMolecular weight:542.49Ref: TM-T4S2326
1mg96.00€5mg264.00€10mg415.00€25mg677.00€50mg935.00€100mg1,254.00€500mg2,527.00€1mL*10mM (DMSO)315.00€I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purity:99.64% - 99.88%Color and Shape:SolidMolecular weight:482.92Licarin A
CAS:Licarin A is a natural anti-inflammatory lignan that inhibits PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2)and COX-2.Formula:C20H22O4Purity:99.5%Color and Shape:SolidMolecular weight:326.392-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.Formula:C17H16O5Purity:98.68%Color and Shape:SolidMolecular weight:300.31Ref: TM-T50064
1mg86.00€2mg114.00€5mg170.00€10mg255.00€25mg437.00€50mg640.00€100mg910.00€500mg1,833.00€1mL*10mM (DMSO)170.00€Saponarin
CAS:Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.Formula:C27H30O15Purity:98.84%Color and Shape:SolidMolecular weight:594.52Theaflavin 3,3'-digallate
CAS:Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.7HS-276
CAS:HS-276, a selective oral TAK1 inhibitor (Ki: 2.5 nM), also targets CLK2, GCK, ULK2, MAP4K5; potential for RA research.Formula:C24H29N5O2Purity:98.07%Color and Shape:SolidMolecular weight:419.52Ref: TM-T62209
1mg70.00€5mg153.00€10mg230.00€25mg454.00€50mg727.00€100mg1,121.00€200mg1,510.00€1mL*10mM (DMSO)172.00€Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.13% - 98.3%Color and Shape:SolidMolecular weight:471.46Ref: TM-T6971
1mg57.00€2mg82.00€5mg115.00€10mg172.00€25mg329.00€50mg527.00€100mg758.00€1mL*10mM (DMSO)118.00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formula:C15H12ClN5Purity:98.07%Color and Shape:SolidMolecular weight:297.74Ref: TM-T11942
5mg47.00€10mg79.00€25mg153.00€50mg235.00€100mg374.00€200mg552.00€500mg840.00€1mL*10mM (DMSO)50.00€IHMT-RAF-128
CAS:IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor models without causing significant toxicity.Formula:C27H24F3N5O2Color and Shape:SolidMolecular weight:507.51SJFα
CAS:SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.Formula:C59H67F2N7O11SPurity:95.25%Color and Shape:SolidMolecular weight:1120.27JNK2-IN-1
JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α andFormula:C30H26N4O5Purity:98%Color and Shape:SolidMolecular weight:522.55Tauroursodeoxycholate dihydrate
CAS:Tauroursodeoxycholate (TUDCA ,Taurolite) dihydrate is a bile acid that reduces Caspase-3, Caspase-12, ERK, reducing endoplasmic reticulum stress mediated death.Formula:C26H49NO8SPurity:99.82%Color and Shape:SolidMolecular weight:535.73KO-947
CAS:KO-947 is a potent and specific inhibitor of ERK1/2 kinases.Formula:C21H17N5OPurity:96.81%Color and Shape:SolidMolecular weight:355.39Catalposide
CAS:Catalposide from Catalpa ovata has antioxidant, anti-inflammatory, and anti-tumor properties.Formula:C22H26O12Purity:99.82%Color and Shape:SolidMolecular weight:482.43Peonidin chloride
CAS:Peonidin chloride has antioxidant activity.Formula:C16H13ClO6Purity:98%Color and Shape:SolidMolecular weight:336.72BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurity:97.33% - 99.07%Color and Shape:SolidMolecular weight:569.67ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Formula:C25H20N4O2Purity:99.72% - 99.79%Color and Shape:SolidMolecular weight:408.45Ref: TM-T15250
2mg35.00€5mg52.00€10mg96.00€25mg148.00€50mg226.00€100mg335.00€500mg730.00€1mL*10mM (DMSO)58.00€MEK ligand-2
CAS:MEK ligand-2, a ligand for the target protein for PROTAC (Ligand for Target Protein for PROTAC), functions as an inhibitor for both MEK1 and MEK2. This compound plays a crucial role in MS934, which is a VHL-recruiting MEK1/2 PROTAC degrader.Formula:C13H8F3IN2O2Color and Shape:SolidMolecular weight:408.12TAO Kinase inhibitor 1
CAS:TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.Formula:C25H24N2O2Purity:99.74%Color and Shape:SolidMolecular weight:384.47Ref: TM-T16987
5mg46.00€10mg64.00€25mg125.00€50mg226.00€100mg338.00€200mg469.00€1mL*10mM (DMSO)49.00€p38 MAP Kinase-IN-1
CAS:p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.Formula:C20H19FN6OColor and Shape:SolidMolecular weight:378.403BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Formula:C22H26N6O2Purity:98.11%Color and Shape:SolidMolecular weight:406.48Ref: TM-T6789
1mg87.00€2mg120.00€5mg210.00€10mg299.00€25mg502.00€50mg730.00€100mg1,026.00€1mL*10mM (DMSO)210.00€GW806742X
CAS:GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.Formula:C25H22F3N7O4SPurity:98.30%Color and Shape:SolidMolecular weight:573.55Bakkenolide IIIa
CAS:Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Formula:C24H32O6SPurity:98%Color and Shape:SolidMolecular weight:448.57p38 Kinase inhibitor 4
CAS:Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].Formula:C12H9Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:282.13KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Color and Shape:SolidMolecular weight:1088.24SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Formula:C24H26F3N5OPurity:98%Color and Shape:SolidMolecular weight:457.49JNK3 inhibitor-9
JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.Formula:C25H27N7O2Molecular weight:457.528Quercetin 3,4'-dimethyl ether
CAS:Quercetin 3,4'-dimethyl ether: anti-lipid peroxidation (IC50=0.3μM), anti-inflammatory, pro-apoptotic, anti-leukemia potential.Formula:C17H14O7Purity:98%Color and Shape:SolidMolecular weight:330.29ERK2 IN-1
CAS:ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.Formula:C36H34FN7O2SPurity:98%Color and Shape:SolidMolecular weight:647.76δ-Tocotrienol
CAS:δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor.Formula:C27H40O2Purity:97.38%Color and Shape:SolidMolecular weight:396.61Ref: TM-TMA2474
1mg48.00€5mg97.00€10mg154.00€25mg298.00€50mg445.00€100mg660.00€1mL*10mM (DMSO)106.00€Andrograpanin
CAS:Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.Formula:C20H30O3Purity:99.03%Color and Shape:SolidMolecular weight:318.45MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formula:C14H9F4N5O4SPurity:98.36% - 99.39%Color and Shape:SolidMolecular weight:419.31Enniatin A1
CAS:Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formula:C35H61N3O9Purity:98%Color and Shape:SolidMolecular weight:667.885CID-1067700
CAS:CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).Formula:C18H18N2O4S2Purity:99.46%Color and Shape:SolidMolecular weight:390.48Ref: TM-T7558
1mg35.00€2mg52.00€5mg74.00€10mg111.00€25mg188.00€50mg246.00€100mg319.00€1mL*10mM (DMSO)82.00€KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormula:C30H36FN5O4Purity:98%Color and Shape:SolidMolecular weight:549.64ML-191
CAS:ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.Formula:C24H25N3O3Purity:99.58%Color and Shape:SolidMolecular weight:403.47Acumapimod
CAS:Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).Formula:C22H19N5O2Purity:≥95%Color and Shape:SolidMolecular weight:385.42Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Formula:C20H17FO2SPurity:99.68%Color and Shape:SolidMolecular weight:340.41JNK Inhibitor VIII
CAS:JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Formula:C18H20N4O4Purity:98.93%Color and Shape:SolidMolecular weight:356.38BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Formula:C19H23F2N5O2Purity:98.51% - 99.43%Color and Shape:SolidMolecular weight:391.42Ref: TM-T6171
1mg52.00€2mg78.00€5mg137.00€10mg207.00€25mg335.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)117.00€SB 239063
CAS:SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4AKP-001
CAS:AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.Formula:C21H13ClF2N4O2Purity:99.50% - 99.92%Color and Shape:SolidMolecular weight:426.8HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Formula:C23H26N6O3Purity:97.2%Color and Shape:SolidMolecular weight:434.49Ref: TM-T40350
1mg130.00€5mg311.00€10mg472.00€25mg825.00€50mg1,130.00€100mg1,549.00€1mL*10mM (DMSO)344.00€Cristacarpin
CAS:Cristacarpin targets DNA repair-deficient yeast, induces ER stress and ROS, triggers senescence in pancreatic/breast cancer by halting G1 cell cycle.Formula:C21H22O5Purity:98%Color and Shape:SolidMolecular weight:354.402PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Formula:C23H18F3N5OPurity:98%Color and Shape:SolidMolecular weight:437.42Cajanin
CAS:Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterolFormula:C16H12O6Purity:98%Color and Shape:SolidMolecular weight:300.26NVP-BAW2881
CAS:NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Formula:C22H15F3N4O2Purity:98.19% - 99.97%Color and Shape:SolidMolecular weight:424.38Ref: TM-T3641
1mg35.00€2mg50.00€5mg74.00€10mg115.00€25mg212.00€50mg343.00€100mg495.00€500mg1,111.00€1mL*10mM (DMSO)72.00€Alpinumisoflavone
CAS:Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. AlpFormula:C20H16O5Color and Shape:SolidMolecular weight:336.34Bakuchiol
CAS:Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.Formula:C18H24OPurity:98.69% - 99.47%Color and Shape:Brownish Yellow Liquid ViscousMolecular weight:256.38Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formula:C19H20F2N4O4Purity:97.63% - 99.99%Color and Shape:SolidMolecular weight:406.38Ref: TM-T6927
1mg56.00€5mg119.00€10mg187.00€25mg378.00€50mg605.00€100mg852.00€500mg1,700.00€1mL*10mM (DMSO)131.00€RLX-33
CAS:RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.Formula:C24H19ClN4O4Purity:99.82%Color and Shape:SolidMolecular weight:462.89Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Formula:C19H19ClFN3O4SPurity:95.83% - 98.39%Color and Shape:SoildMolecular weight:439.89PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purity:100% - 99.66%Color and Shape:Yellow SolidMolecular weight:267.28Ref: TM-T2623
5mg40.00€10mg52.00€25mg82.00€50mg106.00€100mg177.00€200mg264.00€500mg444.00€1mL*10mM (DMSO)58.00€mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purity:99.26%Color and Shape:SolidMolecular weight:1948.31Ravoxertinib hydrochloride
CAS:Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).Formula:C21H19Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:477.32PDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Formula:C22H18F2N4O3SColor and Shape:SolidMolecular weight:456.47NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purity:98.77%Color and Shape:SolidMolecular weight:330.092AL 8697
CAS:AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.Formula:C21H21F3N4OPurity:98.96% - 99.26%Color and Shape:SolidMolecular weight:402.41Ref: TM-T10277
1mg70.00€5mg145.00€10mg207.00€25mg348.00€50mg495.00€100mg678.00€500mgTo inquire1mL*10mM (DMSO)169.00€ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purity:98%Color and Shape:SolidMolecular weight:586.08
