MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.Formula:C55H95N19O13Purity:96.63%Color and Shape:SolidMolecular weight:1230.46D-JNKI-1
CAS:D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44KS-58
CAS:KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Formula:C64H89FN12O14S2Color and Shape:SolidMolecular weight:1333.59ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purity:98.59%Color and Shape:SoildMolecular weight:339.43CK1δ-IN-9
CAS:CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.Formula:C16H12FN5Color and Shape:SolidMolecular weight:293.298JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formula:C13H7ClN4SPurity:98.74%Color and Shape:SolidMolecular weight:286.74Nothofagin
CAS:Nothofagin: Antioxidant, anti-inflammatory, prevents clotting, inhibits leukocyte activity, may treat vascular inflammation.Formula:C21H24O10Purity:99.21%Color and Shape:SolidMolecular weight:436.41Ref: TM-TN1996
1mg279.00€5mg620.00€10mg843.00€25mg1,264.00€50mg1,663.00€100mg2,262.00€1mL*10mM (DMSO)702.00€JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52Rosin
CAS:Rosin is a natural product,may have therapeutic potential for the treatment of inflammationFormula:C15H20O6Purity:99.75% - 99.85%Color and Shape:SolidMolecular weight:296.32SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurity:99.50% - 99.81%Color and Shape:SolidMolecular weight:490.56Ref: TM-T16927
1mg52.00€5mg103.00€10mg160.00€25mg304.00€50mg550.00€100mg882.00€500mg1,768.00€1mL*10mM (DMSO)114.00€PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purity:99.75%Color and Shape:SolidMolecular weight:476.23Ref: TM-T21980
1mg64.00€5mg138.00€10mg188.00€25mg330.00€50mg472.00€100mg655.00€500mg1,293.00€1mL*10mM (DMSO)160.00€CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Formula:C22H20FNO2Purity:99.67%Color and Shape:SolidMolecular weight:349.4Ref: TM-T14988
1mg37.00€5mg104.00€10mg160.00€25mg281.00€50mg442.00€100mg685.00€500mg1,605.00€1mL*10mM (DMSO)114.00€Licochalcone D
CAS:Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Formula:C21H22O5Purity:99.03% - 99.9%Color and Shape:SolidMolecular weight:354.4KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formula:C32H36ClN7O2Purity:98%Color and Shape:SolidMolecular weight:586.13SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Formula:C10H5ClN4O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:328.69Ref: TM-T22115
5mg47.00€10mg74.00€25mg135.00€50mg188.00€100mg283.00€200mg411.00€1mL*10mM (DMSO)50.00€DL-Sulforaphane N-acetyl-L-cysteine
CAS:DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formula:C11H20N2O4S3Color and Shape:SolidMolecular weight:340.48NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Formula:C29H30F3N5O2Purity:97.59% - ≥95%Color and Shape:SolidMolecular weight:537.58Ref: TM-T5643
1mg87.00€5mg160.00€10mg250.00€25mg502.00€50mg715.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)185.00€DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurity:100%Color and Shape:SolidMolecular weight:301.41TH-Z827
CAS:TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Formula:C30H38N6OPurity:98%Color and Shape:SolidMolecular weight:498.66Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Color and Shape:Odour Solid
