MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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Haginin A
CAS:Haginin A inhibits hyperpigmentation and skin disorders, reduces tyrosinase/TRP-1, and has antioxidant properties.Formula:C17H16O5Purity:98%Color and Shape:SolidMolecular weight:300.31PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurity:96.27% - 96.27%Color and Shape:SolidMolecular weight:512.53KRAS inhibitor-31
CAS:KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Formula:C33H30F3N5O4Color and Shape:SolidMolecular weight:617.62RAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Formula:C27H28ClF4N5O2Purity:99.66%Color and Shape:SolidMolecular weight:565.99HI-TOPK-032
CAS:HI-TOPK-032 is an effective and specific inhibitor of TOPK.Formula:C20H11N5OSPurity:98.52%Color and Shape:SolidMolecular weight:369.4ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purity:97.81%Color and Shape:SolidMolecular weight:430.84Ref: TM-T10376
1mg52.00€5mg117.00€10mg170.00€25mg325.00€50mg469.00€100mg615.00€1mL*10mM (DMSO)134.00€BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purity:99.20% - 99.66%Color and Shape:SolidMolecular weight:462.46Ref: TM-T12979
1mg73.00€5mg160.00€10mg250.00€25mg464.00€50mg663.00€100mg919.00€500mg1,833.00€1mL*10mM (DMSO)170.00€L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurity:≥95%Color and Shape:SolidMolecular weight:347.8Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formula:C13H11F3N2OSColor and Shape:SolidMolecular weight:300.3AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formula:C28H21N7OSPurity:98.35% - 98.9%Color and Shape:SolidMolecular weight:503.58Ref: TM-T6380
1mg52.00€5mg97.00€10mg166.00€25mg303.00€50mg467.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)105.00€INS018 055
CAS:INS018 055 (TNIK&MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.Formula:C27H30FN7OPurity:98.53%Color and Shape:SolidMolecular weight:487.57MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Color and Shape:SolidMolecular weight:649.4Griffipavixanthone
CAS:Griffipavixanthone blocks H520 lung cancer growth, induces apoptosis via mitochondria & ROS, halts esophageal cancer spread by targeting RAF pathway.Formula:C36H28O12Purity:98%Color and Shape:SolidMolecular weight:652.6JTP10-△-R9 TFA
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formula:C119H214F3N53O26Purity:98%Color and Shape:SolidMolecular weight:2860.31Morelloflavone
CAS:Morelloflavone(Fukugetin) is an anticancer biflavonoid that inhibits tumor angiogenesis by targeting Rho GTPases and ERK signaling pathways.Formula:C30H20O11Color and Shape:SolidMolecular weight:556.47Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Formula:C38H56N2O4Purity:98%Color and Shape:SolidMolecular weight:604.86VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purity:98.92% - ≥98%Color and Shape:SolidMolecular weight:500.35XMD17-109
CAS:XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).Formula:C36H46N8O3Purity:98.86% - 99.75%Color and Shape:SolidMolecular weight:638.8Ref: TM-T1842
1mg42.00€2mg52.00€5mg87.00€10mg144.00€25mg221.00€50mg359.00€100mg538.00€1mL*10mM (DMSO)110.00€NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Formula:C22H15NO2Purity:98%Color and Shape:SolidMolecular weight:325.36
