p38 MAPK
p38 MAPKs are a subgroup of MAPKs that respond to stress signals and are involved in the regulation of inflammation, cell differentiation, apoptosis, and autophagy. p38 MAPK signaling is crucial in immune responses and is implicated in various diseases, including chronic inflammatory conditions, cancer, and neurodegenerative disorders. At CymitQuimica, we provide a comprehensive range of p38 MAPK inhibitors and modulators to support your research in inflammation, stress response, and therapeutic development.
Products of "p38 MAPK"
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Lucidenic acid D
CAS:Lucidenic acid D2 is a nartural product from G. lucidum AF.Formula:C29H38O8Purity:98%Color and Shape:SolidMolecular weight:514.61Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purity:98.11% - 98.87%Color and Shape:SolidMolecular weight:578.52PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purity:97.79% - 97.90%Color and Shape:SolidMolecular weight:477.3Ref: TM-T1974
1mg46.00€5mg94.00€10mg144.00€25mg255.00€50mg406.00€100mg628.00€500mg1,320.00€1mL*10mM (DMSO)97.00€Bisabolangelone
CAS:Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.Formula:C15H20O3Purity:98.91%Color and Shape:SolidMolecular weight:248.32Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formula:C14H8O5Color and Shape:SolidMolecular weight:256.213-Methyl Adenine
CAS:Applications 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)Formula:C6H7N5Color and Shape:White SolidMolecular weight:149.15p38 Kinase inhibitor 7
CAS:p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Formula:C22H25FN6OColor and Shape:SolidMolecular weight:408.4725,6,7-TRIMETHOXYFLAVONE
CAS:5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.Formula:C18H16O5Purity:99.05% - 99.11%Color and Shape:SolidMolecular weight:312.322-Aminooctadecane-1,3,4-Triol
CAS:2-Aminooctadecane-1,3,4-Triol (Phytosphingosine) is a natural product.Formula:C18H39NO3Purity:≥98%Color and Shape:SolidMolecular weight:317.51p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formula:C16H13FN2OS2Purity:97.79%Color and Shape:SolidMolecular weight:332.42SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Formula:C10H5ClN4O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:328.69Ref: TM-T22115
5mg47.00€10mg74.00€25mg135.00€50mg188.00€100mg283.00€200mg411.00€1mL*10mM (DMSO)50.00€Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Formula:C30H48O5Purity:96.91% - 99.97%Color and Shape:SolidMolecular weight:488.7Samidin
CAS:Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.Formula:C21H22O7Purity:98%Color and Shape:SolidMolecular weight:386.4Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFormula:C22H30O2Purity:98%Color and Shape:SolidMolecular weight:326.47CAL-101
CAS:Controlled ProductApplications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor. References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);Formula:C22H18FN7OColor and Shape:Light BrownMolecular weight:415.40SSK1
CAS:SSK1 is a senescent cell-killing and β-galactosidase-targeting precursor compound that activates phosphorylation levels of p38 MAPK in senescent cells.Formula:C31H34F2N4O18Purity:98.97% - 99.83%Color and Shape:SolidMolecular weight:788.61SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Formula:C16H12FN3SPurity:98% - 99.68%Color and Shape:SolidMolecular weight:297.35p38 MAPK-IN-1
CAS:p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.Formula:C21H14F2N2OPurity:98%Color and Shape:SolidMolecular weight:348.35Esculin
CAS:Esculin (Aesculin) is a glucoside found in horse chestnuts.Formula:C15H16O9Purity:99.46% - 99.83%Color and Shape:Cream PowderMolecular weight:340.28BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Formula:C22H27ClN6O2Purity:97.57% - 98.75%Color and Shape:SolidMolecular weight:442.95Ref: TM-T3462
1mg35.00€5mg71.00€10mg101.00€25mg170.00€50mg264.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)78.00€p38 MAPK Inhibitor
CAS:p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Formula:C20H13ClFN3OPurity:99.24%Color and Shape:SolidMolecular weight:365.79Ref: TM-T36010
1mg96.00€5mg294.00€10mg459.00€25mg677.00€50mg929.00€100mg1,235.00€200mg1,681.00€500µg59.00€WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formula:C28H32N8O3Purity:98.98%Color and Shape:SolidMolecular weight:528.61EO-1606
CAS:EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.Formula:C21H17ClFNOPurity:98.84% - 99.27%Color and Shape:SolidMolecular weight:353.82R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Formula:C19H19ClF2N4O3Purity:99.42%Color and Shape:SolidMolecular weight:424.83TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purity:98.77% - 99.94%Color and Shape:SolidMolecular weight:351.32Ref: TM-T4645
2mg35.00€5mg52.00€10mg85.00€25mg156.00€50mg235.00€100mg329.00€200mg464.00€1mL*10mM (DMSO)71.00€TAK-715
CAS:TAK-715 is a p38 MAPK inhibitor for p38α.Formula:C24H21N3OSPurity:99.69%Color and Shape:SolidMolecular weight:399.51Ref: TM-T6150
1mg40.00€2mg52.00€5mg87.00€10mg99.00€25mg170.00€50mg324.00€100mg507.00€1mL*10mM (DMSO)96.00€Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purity:98.66%Color and Shape:SolidMolecular weight:500.78Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFormula:C27H30O15Purity:96.96% - 98.17%Color and Shape:SolidMolecular weight:594.5Ref: TM-T5S0089
1mg50.00€5mg97.00€10mg143.00€25mg226.00€50mg340.00€100mg495.00€200mg682.00€1mL*10mM (DMSO)129.00€Scio-323
CAS:Scio-323是一种可口服的 p38丝裂原活化蛋白(MAPK)激酶抑制剂。Formula:C27H30FN3O4Purity:100.00%Color and Shape:SolidMolecular weight:479.54Ref: TM-T68139
1mg115.00€5mg245.00€10mg363.00€25mg562.00€50mg775.00€100mg1,035.00€200mg1,406.00€1mL*10mM (DMSO)294.00€(-)-Bornyl acetate
CAS:L-(-)-Bornyl acetate, an enantiomer from hyssop oil, offers antifungal, skin-whitening, and antioxidant benefits, and reduces inflammation.Formula:C12H20O2Purity:≥98%Color and Shape:LiquidMolecular weight:196.29Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formula:C23H17NO2Se2Color and Shape:SolidMolecular weight:497.31FR 167653
CAS:FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Formula:C24H20FN5O6SPurity:98%Color and Shape:SolidMolecular weight:525.51Esculin sesquihydrate
CAS:Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimentalFormula:C15H16O9H2OPurity:98%Color and Shape:SolidMolecular weight:367.31p38α inhibitor 5
CAS:The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Formula:C26H23BrF2N2O3Color and Shape:SolidMolecular weight:529.37PF-03715455
CAS:PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.Formula:C35H34ClN7O3S2Purity:98%Color and Shape:SolidMolecular weight:700.27UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Formula:C30H31F3N8O3SPurity:98.72% - 99.52%Color and Shape:SolidMolecular weight:640.68UR13870
CAS:UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Formula:C24H16F2N4Purity:100% - 98.92%Color and Shape:SolidMolecular weight:398.41Quercetin
CAS:Controlled ProductFormula:C15H10O7Color and Shape:Yellow Crystalline PowderMolecular weight:302.24AMG-548
CAS:AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.Formula:C29H27N5OPurity:98%Color and Shape:SolidMolecular weight:461.56p38-α MAPK-IN-9
CAS:p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.Formula:C19H20N8O2Color and Shape:SolidMolecular weight:392.414PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Formula:C27H26N6O2Purity:98.04%Color and Shape:SolidMolecular weight:466.53PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Formula:C21H18N4OSPurity:98.13%Color and Shape:SolidMolecular weight:374.46Ref: TM-T16501
1mg37.00€5mg111.00€10mg202.00€25mg416.00€50mg620.00€100mg832.00€500mg1,663.00€1mL*10mM (DMSO)187.00€
