Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
Products of "Raf"
Sort by
B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formula:C20H17F2N5O4SPurity:98.2%Color and Shape:SolidMolecular weight:461.44GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purity:95.76%Color and Shape:SolidMolecular weight:334.37Ref: TM-T6320
1mg38.00€2mg49.00€5mg79.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€200mg807.00€1mL*10mM (DMSO)87.00€Brimarafenib
CAS:Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Formula:C24H17F3N4O4Purity:98.32%Color and Shape:SolidMolecular weight:482.41B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurity:97.22% - 99.27%Color and Shape:SolidMolecular weight:515.53Ref: TM-T1845
1mg92.00€2mg119.00€5mg187.00€10mg329.00€25mg560.00€50mg800.00€100mg1,103.00€1mL*10mM (DMSO)221.00€RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurity:99.56%Color and Shape:SolidMolecular weight:518.41Ref: TM-T6296
1mg47.00€2mg63.00€5mg87.00€10mg147.00€25mg266.00€50mg435.00€100mg640.00€1mL*10mM (DMSO)99.00€SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purity:95.42% - 99.06%Color and Shape:SolidMolecular weight:453.54SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formula:C22H24F3N5OPurity:98.79%Color and Shape:SolidMolecular weight:431.45Ref: TM-T60029
1mg75.00€5mg169.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€1mL*10mM (DMSO)180.00€Anti-Phospho-RAF1 (Ser621) Antibody (2K681)
Anti-Phospho-RAF1 (Ser621) Antibody (2K681) is an antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Antibody (2K681) can be used in ELISA, WB, IF.Color and Shape:Odour LiquidVemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Formula:C23H18ClF2N3O3SPurity:98% - 99.65%Color and Shape:SolidMolecular weight:489.92Anti-Phospho-RAF1 (Ser43) Antibody (8R108)
Anti-Phospho-RAF1 (Ser43) Antibody (8R108) is an antibody targeting Phospho-RAF1 (Ser43). Anti-Phospho-RAF1 (Ser43) Antibody (8R108) can be used in ELISA, IF.Color and Shape:Odour LiquidRMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purity:99.81%Color and Shape:SolidMolecular weight:499.91Ref: TM-T38170
1mg145.00€2mg210.00€5mg354.00€10mg630.00€25mg1,301.00€50mg2,015.00€100mg3,002.00€1mL*10mM (DMSO)378.00€AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurity:100% - 99.49%Color and Shape:SolidMolecular weight:473.43Ref: TM-T4301
1mg47.00€5mg92.00€10mg145.00€25mg283.00€50mg464.00€100mg680.00€500mg1,406.00€1mL*10mM (DMSO)96.00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purity:98.05%Color and Shape:SolidMolecular weight:478.94Regorafénib N-oxyde (M2)
CAS:Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.Formula:C21H15ClF4N4O4Purity:98.03% - 99.48%Color and Shape:SolidMolecular weight:498.81Ref: TM-T10157
1mg44.00€2mg56.00€5mg80.00€10mg103.00€25mg180.00€50mg324.00€100mg472.00€1mL*10mM (DMSO)88.00€NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formula:C22H18F2N4O5SPurity:98.62%Color and Shape:SolidMolecular weight:488.46PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formula:C25H21F3N6O3SPurity:100% - 98.22%Color and Shape:SolidMolecular weight:542.53Ref: TM-T3579
2mg42.00€5mg59.00€10mg99.00€25mg165.00€50mg265.00€100mg472.00€200mg687.00€1mL*10mM (DMSO)72.00€CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formula:C27H24FN7O3Purity:98.58% - 98.93%Color and Shape:SolidMolecular weight:513.52BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurity:96.8%Color and Shape:SolidMolecular weight:448.58TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Formula:C17H12Cl2F3N7O2SPurity:99.25% - 99.77%Color and Shape:SolidMolecular weight:506.29Ref: TM-T6895
1mg52.00€2mg74.00€5mg103.00€10mg180.00€25mg303.00€50mg445.00€100mg655.00€1mL*10mM (DMSO)116.00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurity:99.03%Color and Shape:SolidMolecular weight:528.49Ref: TM-T15794
1mg66.00€5mg142.00€10mg188.00€25mg346.00€50mg487.00€100mg682.00€1mL*10mM (DMSO)166.00€K-Ras(G12C) Inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.33Ref: TM-T3725
1mg63.00€2mg88.00€5mg133.00€10mg230.00€25mg477.00€50mg667.00€100mg932.00€1mL*10mM (DMSO)133.00€Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purity:99.45% - 99.62%Color and Shape:SolidMolecular weight:615.67Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purity:99.69%Color and Shape:SolidMolecular weight:500.83Ref: TM-T1792L
5mg35.00€10mg48.00€25mg69.00€50mg88.00€100mg140.00€200mg207.00€500mg348.00€1mL*10mM (DMSO)58.00€K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurity:97.33% - 97.45%Color and Shape:SolidMolecular weight:513.78Ref: TM-T6556
1mg52.00€2mg74.00€5mg123.00€10mg183.00€25mg378.00€50mg547.00€100mg750.00€1mL*10mM (DMSO)183.00€Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurity:98.27%Color and Shape:SolidMolecular weight:547.99Ref: TM-T22436
1mg97.00€2mg135.00€5mg188.00€10mg283.00€25mg462.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)255.00€Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Formula:C75H108FN25O13·xC2HF3O2Color and Shape:SolidMolecular weight:1586.82 (free base)BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurity:97.33% - 99.07%Color and Shape:SolidMolecular weight:569.67MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63KG5
CAS:KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).Formula:C20H16F3N7OSPurity:98.2%Color and Shape:SolidMolecular weight:459.45Ref: TM-T41003
1mg34.00€2mg47.00€5mg74.00€10mg105.00€25mg205.00€50mg313.00€100mg449.00€200mg628.00€1mL*10mM (DMSO)89.00€LSN3074753
CAS:LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound exhibits inhibitory activity against tumor cells driven by either BRAF monomers or RAF dimers, particularly in the activation of the MAPK pathway, including colorectal cancers with BRAF or KRAS mutations. When combined with Cetuximab, LSN3074753 demonstrates additive and synergistic effects in colorectal cancer PDX models, especially in those harboring KRAS or BRAF mutations.Formula:C24H30FN5O2Color and Shape:SolidMolecular weight:439.53NVP-BAW2881
CAS:NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Formula:C22H15F3N4O2Purity:98.19% - 99.97%Color and Shape:SolidMolecular weight:424.38Ref: TM-T3641
1mg35.00€2mg50.00€5mg74.00€10mg115.00€25mg212.00€50mg343.00€100mg495.00€500mg1,111.00€1mL*10mM (DMSO)72.00€BRAFV600E-IN-1
BRAFV600E-IN-1 (compound 9S) is an inhibitor of BRAF. It exhibits significant apoptotic effects in cell lines expressing mutant KRAS and cancer cells harboring BRAFV600E.Formula:C23H16Cl3N5O4Color and Shape:SolidMolecular weight:532.76LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Formula:C23H29FN6OPurity:96.96% - ≥95%Color and Shape:SolidMolecular weight:424.51Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Formula:C23H20F3N5O2S2Purity:100% - 99.83%Color and Shape:SolidMolecular weight:519.56RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Formula:C28H29F3N4O4Purity:99.43% - 99.83%Color and Shape:SolidMolecular weight:542.55Ref: TM-T3711
1mg40.00€2mg52.00€5mg87.00€10mg131.00€25mg259.00€50mg424.00€100mg625.00€500mg1,311.00€1mL*10mM (DMSO)94.00€CCT241161
CAS:CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.Formula:C28H27N7O3SPurity:100% - 98.48%Color and Shape:SolidMolecular weight:541.62Zabofloxacin hydrochloride
CAS:Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.Formula:C19H21ClFN5O4Purity:98%Color and Shape:SolidMolecular weight:437.86Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurity:98.64% - 99.74%Color and Shape:SolidMolecular weight:540.01NVP-BHG712
CAS:NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src andFormula:C26H20F3N7OPurity:97.32%Color and Shape:SolidMolecular weight:503.48Ref: TM-T6348
1mg35.00€5mg79.00€10mg111.00€25mg212.00€50mg393.00€100mg587.00€200mg833.00€1mL*10mM (DMSO)88.00€I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purity:99.64% - 99.88%Color and Shape:SolidMolecular weight:482.92Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.13% - 98.3%Color and Shape:SolidMolecular weight:471.46Ref: TM-T6971
1mg57.00€2mg82.00€5mg115.00€10mg172.00€25mg329.00€50mg527.00€100mg758.00€1mL*10mM (DMSO)118.00€IHMT-RAF-128
CAS:IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor models without causing significant toxicity.Formula:C27H24F3N5O2Color and Shape:SolidMolecular weight:507.51
