Membrane Transporter/Ion Channel
Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.
Subcategories of "Membrane Transporter/Ion Channel"
- ABC
- Adiponectin receptor
- ATPase
- Calcium Channel
- CFTR
- CGRP Receptor
- Chloride channel
- GABA Receptor
- Monoamine Transporter
- Monocarboxylate transporter
- Na-K-Cl cotransporter
- NKCC
- NPC1L1
- OAT
- OCT
- P-gp
- Potassium Channel
- Proton pump
- SGLT
- Sodium Channel
- TRP/TRPV Channel
Show 13 more subcategories
Products of "Membrane Transporter/Ion Channel"
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Atpenin A5
CAS:Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM).Formula:C15H21Cl2NO5Purity:97.33% - 99.91%Color and Shape:SolidMolecular weight:366.24Pimozide
CAS:Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.Formula:C28H29F2N3OPurity:100% - 99.85%Color and Shape:SolidMolecular weight:461.55QX-222 chloride
CAS:QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.Formula:C13H21ClN2OPurity:96.21%Color and Shape:SolidMolecular weight:256.77QO-40
CAS:QO-40 is a KCNQ2/3 potassium channels activator.Formula:C18H11ClF3N3OPurity:99.57%Color and Shape:SolidMolecular weight:377.75GpTx-1
CAS:GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].Formula:C176H271N53O45S7Purity:98%Color and Shape:SolidMolecular weight:4073.82Fluralaner
CAS:Fluralaner (A1443) is an isoxazoline ectoparasiticide.Formula:C22H17Cl2F6N3O3Purity:99.72% - 99.90%Color and Shape:Solid PowderMolecular weight:556.29Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Formula:C23H27ClN2O2SPurity:99.08%Color and Shape:SolidMolecular weight:430.99Ref: TM-T19723
1mg37.00€5mg79.00€10mg126.00€25mg264.00€50mg449.00€100mg662.00€200mg939.00€1mL*10mM (DMSO)92.00€Raxatrigine
CAS:Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.Formula:C18H19FN2O2Purity:99.43%Color and Shape:SolidMolecular weight:314.35Etidocaine Hydrochloride
CAS:Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.Formula:C17H29ClN2OPurity:98.71%Color and Shape:SolidMolecular weight:312.88Ref: TM-T31716
1mg116.00€2mg156.00€5mg227.00€10mg341.00€25mg533.00€50mg723.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)273.00€(-)-Bicuculline methobromide
CAS:(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .Formula:C21H20BrNO6Color and Shape:WhiteMolecular weight:462.29TET-13
TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.Formula:C15H16N2O3SColor and Shape:SolidMolecular weight:304.36Disopyramide
CAS:Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.Formula:C21H29N3OPurity:99.62%Color and Shape:SolidMolecular weight:339.47ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Color and Shape:SolidMolecular weight:434.307Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Formula:C23H20ClF3N4O5Purity:99.06%Color and Shape:SolidMolecular weight:524.88Ref: TM-T16532
1mg77.00€5mg165.00€10mg240.00€25mg408.00€50mg562.00€100mg800.00€200mg1,074.00€1mL*10mM (DMSO)187.00€PZ-II-029
CAS:PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.Formula:C18H15N3O3Purity:99.72%Color and Shape:SolidMolecular weight:321.33Ref: TM-T28479
1mg52.00€5mg111.00€10mg170.00€25mg305.00€50mg472.00€100mg723.00€500mg1,454.00€1mL*10mM (DMSO)202.00€O4I1
CAS:O4I1 is an effective Oct3/4 inducer.Formula:C16H15NO2Purity:96.25% - 99.47%Color and Shape:SolidMolecular weight:253.3(5R)-BW-4030W92
CAS:(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.Formula:C11H9Cl2FN4Purity:98.27%Color and Shape:SolidMolecular weight:287.12Cannabidivarin
CAS:Cannabidivarin (GWP42006) inhibits GABAA receptors, potentially controlling childhood absence epilepsy.Formula:C19H26O2Purity:98.06% - 98.51%Color and Shape:SolidMolecular weight:286.41Ref: TM-T8162
1mg52.00€2mg74.00€5mg87.00€10mg140.00€25mg264.00€50mg416.00€100mg615.00€1mL*10mM (DMSO)111.00€AUT1
CAS:AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).Formula:C18H19N3O4Purity:99.80%Color and Shape:SolidMolecular weight:341.36Kv2-IN-A1
CAS:Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.Formula:C20H17ClN4OSPurity:98.83%Color and Shape:SolidMolecular weight:396.89Rosuvastatin
CAS:Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.Formula:C22H28FN3O6SPurity:95.24% - 99.8%Color and Shape:SolidMolecular weight:481.54BMS 199264
CAS:BMS 199264 hydrochlorid a inhibitor of mitochondrial F1F0 ATP hydrolase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia.Formula:C26H31ClN4O4SPurity:99.83%Color and Shape:SoildMolecular weight:531.07Ref: TM-T26843L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€SSD114 HCl
CAS:SSD114 is a novel GABAB receptor positive allosteric modulator.Formula:C18H21ClF3N3OPurity:99.03% - 99.95%Color and Shape:SolidMolecular weight:387.83Ref: TM-T4522
1mg38.00€2mg50.00€5mg88.00€10mg119.00€25mg188.00€50mg300.00€100mg512.00€1mL*10mM (DMSO)74.00€(R)-baclofen
CAS:(R)-baclofen (STX209), a derivative of gamma-aminobutyric acid, is commonly utilized for the treatment of spasticity.Formula:C10H12ClNO2Purity:98.94%Color and Shape:SolidMolecular weight:213.66Hm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1Formula:C170H239N47O54S6Purity:98%Color and Shape:SolidMolecular weight:3997.39Goniothalamin
CAS:Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.Formula:C13H12O2Purity:98%Color and Shape:SolidMolecular weight:200.23Fipronil
CAS:Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family.Formula:C12H4Cl2F6N4OSPurity:97.48%Color and Shape:Solid PowderMolecular weight:437.154-Aminopyridine
CAS:4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.Formula:C5H6N2Purity:90%Color and Shape:SolidMolecular weight:94.11SKA-31
CAS:SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).Formula:C11H8N2SPurity:99.38%Color and Shape:SolidMolecular weight:200.26Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFormula:C17H25ClN2OPurity:99.22% - 99.80%Color and Shape:SolidMolecular weight:308.85Phlo1b
Phlo1b (μ-TrTx-Phlo1b), a 35-amino acid peptide toxin, selectively inhibits Nav1.7 channels with minimal inhibition of Nav1.2 and Nav1.5 [1].Formula:C181H260N52O49S6Purity:98%Color and Shape:SolidMolecular weight:4140.71NO-711ME
CAS:NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.Formula:C22H24N2O3Purity:96.14%Color and Shape:SolidMolecular weight:364.44Ref: TM-T24540
1mg87.00€2mg124.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)202.00€SM-6586
CAS:SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascularFormula:C26H27N5O5Purity:99.43%Color and Shape:SolidMolecular weight:489.52BMS-191011
CAS:BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke modelsFormula:C16H10ClF3N2O3Purity:97.43%Color and Shape:SolidMolecular weight:370.71AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Formula:C20H12F5N3O4Purity:99.95%Color and Shape:SolidMolecular weight:453.32Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Formula:C19H23F2N3O2Color and Shape:SolidMolecular weight:363.4Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Formula:C12H13F6N3O3Purity:98.39%Color and Shape:SolidMolecular weight:361.24Ref: TM-T9499
1mg160.00€5mg329.00€10mg495.00€25mg792.00€50mg1,111.00€100mg1,578.00€200mg2,137.00€1mL*10mM (DMSO)261.00€Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formula:C11H14ClN3O3S2Color and Shape:SolidMolecular weight:335.83VX-150
CAS:VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).Formula:C21H17F4N2O7PPurity:95.06%Color and Shape:SolidMolecular weight:516.34Ref: TM-T9683
1mg70.00€5mg153.00€10mg246.00€25mg494.00€50mg793.00€100mg1,216.00€200mg1,634.00€1mL*10mM (DMSO)167.00€Gboxin
CAS:Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.Formula:C22H33ClN2O2Purity:100% - 99.58%Color and Shape:SolidMolecular weight:392.96Ref: TM-T15373
1mg47.00€5mg87.00€10mg139.00€25mg271.00€50mg426.00€100mg677.00€200mg935.00€1mL*10mM (DMSO)97.00€Padsevonil
CAS:Padsevonil (UCB-0942) is a potential GABA A receptor orthosteric modulator with antiepileptic activity for the treatment of epilepsy.Formula:C14H14ClF5N4O2SPurity:99.63%Color and Shape:SolidMolecular weight:432.80KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Formula:C13H12FN3O2Purity:99.89%Color and Shape:SolidMolecular weight:261.25Ref: TM-T36569
1mg46.00€5mg92.00€10mg145.00€25mg284.00€50mg411.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)95.00€δ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].Formula:C304H458N90O93S8Purity:98%Color and Shape:SolidMolecular weight:7117.96Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet itFormula:C179H274N50O55S7·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:4230.85 (free base)QX-314 chloride
CAS:QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.Formula:C16H27ClN2OPurity:99.73%Color and Shape:SolidMolecular weight:298.85Chlorahololide C
CAS:Chlorahololide C blocks potassium channels, selectively inhibiting I(K) current with an IC50 of 3.6±10.1 µM.Formula:C33H36O9Purity:98%Color and Shape:SolidMolecular weight:576.63EIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Formula:C11H19Cl2N7OPurity:98%Color and Shape:SolidMolecular weight:336.22Rostafuroxin
CAS:Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Formula:C23H34O4Purity:100% - 99.08%Color and Shape:SolidMolecular weight:374.51MIDD0301
CAS:MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.Formula:C19H13BrFN3O2Purity:98%Color and Shape:SolidMolecular weight:414.23
