CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Products of "CFTR"
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CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Formula:C19H21ClN4O2S2Purity:99.78%Color and Shape:SolidMolecular weight:436.98(R)-Elexacaftor
CAS:(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).Formula:C26H34F3N7O4SPurity:98%Color and Shape:SolidMolecular weight:597.65IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purity:100% - ≥95%Color and Shape:SolidMolecular weight:545.18Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494Ref: TM-T2S1837
1mg52.00€5mg95.00€10mg162.00€25mg264.00€50mg393.00€100mg582.00€200mg830.00€1mL*10mM (DMSO)77.00€Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Formula:C26H34F3N7O4SPurity:98.87% - 99.87%Color and Shape:SolidMolecular weight:597.65Ref: TM-T14935
1mg87.00€2mg137.00€5mg243.00€10mg393.00€25mg772.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)320.00€CFTR corrector 9
CAS:CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Formula:C16H14N2O4Purity:98.24%Color and Shape:SolidMolecular weight:298.29Ref: TM-T60653
2mg42.00€5mg64.00€10mg92.00€25mg178.00€50mg266.00€100mg383.00€200mg537.00€1mL*10mM (DMSO)62.00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg38.00€10mg57.00€25mg93.00€50mg124.00€100mg188.00€200mg225.00€500mg379.00€1mL*10mM (DMSO)48.00€Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Formula:C12H13F6N3O3Purity:98.39%Color and Shape:SolidMolecular weight:361.24Ref: TM-T9499
1mg160.00€5mg329.00€10mg495.00€25mg792.00€50mg1,111.00€100mg1,578.00€200mg2,137.00€1mL*10mM (DMSO)261.00€CFTR corrector 17
CAS:CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.Formula:C18H15FN2O2Color and Shape:SolidMolecular weight:310.32GlyH-101
CAS:GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Formula:C19H15Br2N3O3Purity:98.71% - 98.78%Color and Shape:SolidMolecular weight:493.15Ref: TM-T2451
1mg40.00€2mg51.00€5mg85.00€10mg119.00€25mg246.00€50mg492.00€100mg688.00€200mg908.00€1mL*10mM (DMSO)93.00€GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:98.75% - 99.73%Color and Shape:SolidMolecular weight:348.42Ref: TM-T7083
1mg35.00€5mg80.00€10mg120.00€25mg188.00€50mg354.00€100mg537.00€200mg750.00€1mL*10mM (DMSO)88.00€(R)-BPO-27
CAS:(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.Formula:C26H18BrN3O6Purity:99.1%Color and Shape:SolidMolecular weight:548.34Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Formula:C28H32F3N5O4SPurity:99.85%Color and Shape:SolidMolecular weight:591.65Ref: TM-T30293
1mg354.00€5mg847.00€10mg1,159.00€25mg1,700.00€50mg2,308.00€100mg3,117.00€1mL*10mM (DMSO)1,225.00€CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formula:C18H10F3NO3S2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:409.4Ref: TM-T2355
1mg35.00€2mg46.00€5mg66.00€10mg97.00€25mg188.00€50mg359.00€100mg530.00€1mL*10mM (DMSO)69.00€BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Formula:C26H18BrN3O6Purity:98.19%Color and Shape:SolidMolecular weight:548.34Ref: TM-T10591
1mg47.00€5mg117.00€10mg170.00€25mg280.00€50mg409.00€100mg565.00€200mg758.00€1mL*10mM (DMSO)135.00€VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Formula:C16H14N2OPurity:100% - 99.89%Color and Shape:SolidMolecular weight:250.3CFTR corrector 15
CAS:CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.Formula:C24H22ClN5O2SColor and Shape:SolidMolecular weight:479.98
