TRP/TRPV Channel
TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.
Products of "TRP/TRPV Channel"
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MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Formula:C27H31FN6O2Purity:98.1% - 98.83%Color and Shape:SolidMolecular weight:490.57SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Formula:C17H21F3N4O2SPurity:98.43%Color and Shape:SolidMolecular weight:402.43Ref: TM-T37097
5mg58.00€10mg96.00€25mg177.00€50mg300.00€100mg437.00€500mgTo inquire1mL*10mM (DMSO)71.00€SB 452533
CAS:SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).Formula:C18H22BrN3OPurity:98.52%Color and Shape:SolidMolecular weight:376.29Ref: TM-T23322
2mg42.00€5mg64.00€10mg97.00€25mg183.00€50mg284.00€100mg411.00€200mg585.00€1mL*10mM (DMSO)85.00€Pyr6
CAS:Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influxFormula:C17H9F7N4OPurity:98.89%Color and Shape:SolidMolecular weight:418.27ICILIN
CAS:ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.Formula:C16H13N3O4Purity:97.61% - ≥95%Color and Shape:Light Yellow SolidMolecular weight:311.29ML-SI3
CAS:CCG-143140 is a GLP-1 receptor inverse agonists.Formula:C23H31N3O3SPurity:99.75%Color and Shape:SolidMolecular weight:429.58Fingolimod hydrochloride
CAS:Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).Formula:C19H34ClNO2Purity:99.26% - 99.83%Color and Shape:White SolidMolecular weight:343.93CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Color and Shape:Odour SolidEvifacotrep
CAS:Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).Formula:C18H12ClF4N5O2Purity:98.6%Color and Shape:SolidMolecular weight:441.77Ref: TM-T40042
1mg96.00€5mg188.00€10mg303.00€25mg465.00€50mg692.00€100mg1,026.00€200mg1,549.00€1mL*10mM (DMSO)160.00€AM-0902
CAS:AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).Formula:C17H15ClN6O2Purity:100%Color and Shape:SolidMolecular weight:370.79SN 2
CAS:SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.Formula:C17H21NOPurity:99.20%Color and Shape:SolidMolecular weight:255.35Ref: TM-T12941
5mg52.00€10mg75.00€25mg149.00€50mg283.00€100mg415.00€200mg582.00€1mL*10mM (DMSO)52.00€Olvanil
CAS:Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Formula:C26H43NO3Purity:95.06%Color and Shape:SolidMolecular weight:417.62GSK1702934A
CAS:GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.Formula:C22H25N3O2SPurity:98.15%Color and Shape:SolidMolecular weight:395.529-Phenanthrol
CAS:9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.Formula:C14H10OPurity:98.72%Color and Shape:SolidMolecular weight:194.23Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Formula:C19H23N5O3Purity:99.97%Color and Shape:SolidMolecular weight:369.42TRPV4 agonist-1
CAS:TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).Formula:C25H23ClF2N4O2Purity:98%Color and Shape:SolidMolecular weight:484.93TRPV3 antagonist 74a
CAS:TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.Formula:C17H17F3N2O2Purity:≥98.0%Color and Shape:SolidMolecular weight:338.32JC-229
CAS:JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).Formula:C20H14Cl4N2O3SPurity:97.14%Color and Shape:SolidMolecular weight:504.21AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Formula:C19H17F6N3OPurity:99.05%Color and Shape:SolidMolecular weight:417.35Ref: TM-T10300
1mg74.00€5mg170.00€10mg248.00€25mg445.00€50mg662.00€100mg848.00€1mL*10mM (DMSO)182.00€TC-I2000
CAS:TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.Formula:C23H18F4N2OPurity:98.87%Color and Shape:SolidMolecular weight:414.4ML204
CAS:ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Formula:C15H18N2Purity:98.1% - 99.72%Color and Shape:SolidMolecular weight:226.32Ref: TM-T2298
2mg35.00€5mg50.00€10mg74.00€25mg111.00€50mg145.00€100mg220.00€200mg284.00€500mg467.00€1mL*10mM (DMSO)52.00€ASP7663
CAS:ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Formula:C14H14FNO3Purity:98.61%Color and Shape:SolidMolecular weight:263.26GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Formula:C20H15F4N3O5SPurity:98%Color and Shape:SolidMolecular weight:485.41Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Formula:C18H16ClF3N2OSPurity:98.90%Color and Shape:SolidMolecular weight:400.85Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].Formula:C10H15Cl4N5O2Purity:99.30%Color and Shape:SolidMolecular weight:379.07Ref: TM-T001
1mgTo inquire2mg63.00€5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire200mgTo inquire500mg2,792.00€Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Formula:C18H15N3O2Purity:98.14%Color and Shape:SolidMolecular weight:305.33Ref: TM-T9247
1mg99.00€5mg235.00€10mg354.00€25mg602.00€50mg847.00€100mg1,206.00€1mL*10mM (DMSO)47.00€TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Formula:C24H25F3N4OPurity:98.05%Color and Shape:SoildMolecular weight:442.48Ref: TM-T77511
1mg85.00€5mg187.00€10mg284.00€25mg482.00€50mg672.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)207.00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Formula:C17H17N3O2SPurity:99.19%Color and Shape:SolidMolecular weight:327.4Ref: TM-T27308
1mg35.00€5mg78.00€10mg116.00€25mg190.00€50mg269.00€100mg383.00€200mg525.00€1mL*10mM (DMSO)88.00€TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Formula:C23H19F6N3OPurity:98.75%Color and Shape:SolidMolecular weight:467.41Ref: TM-T17006
1mg60.00€5mg127.00€10mg202.00€25mg406.00€50mg655.00€100mg1,074.00€200mg1,454.00€1mL*10mM (DMSO)133.00€AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Formula:C21H23NO3Purity:99.79% - 99.83%Color and Shape:SolidMolecular weight:337.41JYL 1421
CAS:JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Formula:C20H26FN3O2S2Purity:98.83%Color and Shape:SolidMolecular weight:423.57Ref: TM-T15634
1mg70.00€5mg187.00€10mg305.00€25mg612.00€50mg938.00€100mg1,491.00€200mg1,985.00€1mL*10mM (DMSO)173.00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Formula:C17H18ClN3O4SPurity:99.29%Color and Shape:SolidMolecular weight:395.86Ref: TM-T16763
5mg44.00€10mg74.00€25mg126.00€50mg188.00€100mg316.00€200mg452.00€1mL*10mM (DMSO)47.00€HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Formula:C26H29ClF3N3O2Purity:99.95%Color and Shape:SolidMolecular weight:507.98Ref: TM-T4680L
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)217.00€RN9893
CAS:RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Formula:C21H23F3N4O5SPurity:99.89%Color and Shape:SolidMolecular weight:500.49D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.Formula:C21H32ClN3O3Purity:99.85%Color and Shape:SolidMolecular weight:409.95PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.Formula:C26H38N6O2Purity:98.48%Color and Shape:SolidMolecular weight:466.62A 425619
CAS:A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonistFormula:C18H14F3N3OPurity:99.35%Color and Shape:SolidMolecular weight:345.32Ref: TM-T8562
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Formula:C22H20Cl2N4O4Purity:97.06%Color and Shape:SolidMolecular weight:475.32Ref: TM-T15465
1mg88.00€5mg170.00€10mg259.00€25mg429.00€50mg605.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)168.00€A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectivelyFormula:C12H14FNOPurity:98.34% - 99.75%Color and Shape:SolidMolecular weight:207.24Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Formula:C15H14O4Purity:98.15%Color and Shape:SolidMolecular weight:258.27GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Formula:C37H38BrF3N4OPurity:98.79% - ≥95%Color and Shape:SolidMolecular weight:691.62Ref: TM-T5640
1mg43.00€2mg57.00€5mg81.00€10mg127.00€25mg246.00€50mg404.00€100mg602.00€1mL*10mM (DMSO)111.00€AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Formula:C23H27ClN2O2SPurity:99.08%Color and Shape:SolidMolecular weight:430.99Ref: TM-T19723
1mg37.00€5mg79.00€10mg126.00€25mg264.00€50mg449.00€100mg662.00€200mg939.00€1mL*10mM (DMSO)92.00€Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Formula:C23H20ClF3N4O5Purity:99.06%Color and Shape:SolidMolecular weight:524.88Ref: TM-T16532
1mg77.00€5mg165.00€10mg240.00€25mg408.00€50mg562.00€100mg800.00€200mg1,074.00€1mL*10mM (DMSO)187.00€AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Formula:C20H12F5N3O4Purity:99.95%Color and Shape:SolidMolecular weight:453.32SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Formula:C17H16BrF3N4OPurity:99.16% - ≥95%Color and Shape:SolidMolecular weight:429.23EIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Formula:C11H19Cl2N7OPurity:98%Color and Shape:SolidMolecular weight:336.22GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Formula:C16H14ClF3N4O2Purity:99.58%Color and Shape:SolidMolecular weight:386.76Ref: TM-T11394
2mg35.00€5mg52.00€10mg81.00€25mg117.00€50mg170.00€100mg250.00€200mg369.00€1mL*10mM (DMSO)58.00€AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Formula:C24H26F3N3O2Purity:99.7%Color and Shape:SolidMolecular weight:445.48Ref: TM-T29968
1mg226.00€5mg552.00€10mg735.00€25mg1,111.00€50mg1,491.00€100mg2,005.00€200mg2,707.00€1mL*10mM (DMSO)567.00€ML-SA1
CAS:ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Formula:C22H22N2O3Purity:99.71%Color and Shape:SolidMolecular weight:362.42Ref: TM-T23004
2mg37.00€5mg51.00€10mg81.00€25mg150.00€50mg244.00€100mg364.00€200mg550.00€1mL*10mM (DMSO)58.00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Formula:C16H19ClN2O3SPurity:98.5%Color and Shape:SolidMolecular weight:354.85
