Chloride channel
Chloride channels are membrane proteins that control the movement of chloride ions across cellular membranes, playing a vital role in maintaining cell volume, electrical excitability, and acid-base balance. Dysregulation of chloride channels is linked to diseases such as cystic fibrosis, epilepsy, and kidney disorders. At CymitQuimica, we offer a variety of chloride channel modulators to support your research in ion transport, cellular homeostasis, and disease mechanisms.
Products of "Chloride channel"
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T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formula:C19H20N4O3S2Purity:97.18% - 98.15%Color and Shape:SolidMolecular weight:416.52MONNA
CAS:MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Formula:C18H14N2O5Purity:98.29%Color and Shape:SolidMolecular weight:338.31CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Formula:C18H21NO4SPurity:99.92%Color and Shape:SolidMolecular weight:347.43Picrotoxinin
CAS:Picrotoxinin blocks chloride channels, antagonizes GABAA noncompetitively (IC50: 1.15 μM, α1β2γ2L), and induces convulsions.Formula:C15H16O6Purity:98.07%Color and Shape:SolidMolecular weight:292.28Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Formula:C13H9F3N2O2Purity:99.47%Color and Shape:SolidMolecular weight:282.22Irisolidone
CAS:Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.Formula:C17H14O6Purity:99.41% - 99.46%Color and Shape:SolidMolecular weight:314.29Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formula:C26H17ClF9N3O3Purity:99.10% - 99.38%Color and Shape:SolidMolecular weight:625.87NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.Formula:C15H11F3N2O3Purity:99.62%Color and Shape:SolidMolecular weight:324.25Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Formula:C24H32N2O4Purity:99.13%Color and Shape:SolidMolecular weight:412.52Ref: TM-T50082
1mg84.00€5mg167.00€10mg250.00€25mg414.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)187.00€Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.Formula:C22H24N2O5SPurity:97.01%Color and Shape:SolidMolecular weight:428.5Ref: TM-T15192
1mg37.00€2mg50.00€5mg79.00€10mg126.00€25mg254.00€50mg429.00€100mg632.00€200mg899.00€1mL*10mM (DMSO)87.00€Talniflumate
CAS:Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cellFormula:C21H13F3N2O4Purity:98% - 99.81%Color and Shape:White To Pale Yellow Crystalline PowderMolecular weight:414.33Ref: TM-T4503
1mg37.00€2mg52.00€5mg77.00€10mg97.00€25mg182.00€50mg300.00€100mg449.00€1mL*10mM (DMSO)85.00€Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Formula:C13H11NO2Purity:99.60%Color and Shape:White To Off-White Crystalline PowderMolecular weight:213.2319ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formula:C19H19BrF2N2O2SColor and Shape:SolidMolecular weight:457.33Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purity:99.16%Color and Shape:SolidMolecular weight:275.34Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Formula:C14H10F3NO2Purity:98.68%Color and Shape:White To Light Yellow Crystalline PowderMolecular weight:281.23Shikonin
CAS:Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Formula:C16H16O5Purity:98.13% - 99.9%Color and Shape:SolidMolecular weight:288.3Ref: TM-T1125
5mg34.00€10mg52.00€25mg87.00€50mg140.00€100mg215.00€200mg319.00€500mg533.00€1mL*10mM (DMSO)52.00€DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormula:C22H28Cl2O4Purity:99.79% - 99.87%Color and Shape:SolidMolecular weight:427.36Ref: TM-T10979
1mg35.00€5mg74.00€10mg114.00€25mg235.00€50mg465.00€100mg605.00€200mg852.00€1mL*10mM (DMSO)84.00€Ani9
CAS:Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.Formula:C17H17ClN2O3Purity:98.72%Color and Shape:SolidMolecular weight:332.78Ref: TM-T26630
1mg39.00€5mg84.00€10mg131.00€25mg269.00€50mg454.00€100mg655.00€500mg1,406.00€1mL*10mM (DMSO)92.00€Picrotin
CAS:Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.Formula:C15H18O7Purity:97.11%Color and Shape:SolidMolecular weight:310.3ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Formula:C18H28N2O2SPurity:99.66%Color and Shape:SolidMolecular weight:336.49
