P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Products of "P-gp"
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Found 49 products on this category.
Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formula:C38H36N6O7Purity:99.93%Color and Shape:SolidMolecular weight:688.73Ref: TM-T8426
1mg48.00€2mg65.00€5mg96.00€10mg144.00€25mg246.00€50mg380.00€100mg557.00€1mL*10mM (DMSO)134.00€Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purity:93.19% - 93.19%Color and Shape:SolidMolecular weight:518.51Ref: TM-TN4761
1mg163.00€5mg320.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)410.00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurity:99.37%Color and Shape:SolidMolecular weight:802.85Ref: TM-T9173
1mg69.00€2mg88.00€5mg126.00€10mg195.00€25mg325.00€50mg467.00€100mg680.00€200mg882.00€500mg1,320.00€1mL*10mM (DMSO)187.00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formula:C34H33N3O5Purity:100% - 99.62%Color and Shape:SolidMolecular weight:563.64Ref: TM-T2657
5mg42.00€10mg63.00€25mg107.00€50mg188.00€100mg283.00€200mg472.00€500mg753.00€1mL*10mM (DMSO)57.00€Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H58N4O18S2Purity:98.13%Color and Shape:SolidMolecular weight:947.04Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purity:99.17% - 99.88%Color and Shape:SolidMolecular weight:868.06Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purity:99.47%Color and Shape:SolidMolecular weight:477.04Ref: TM-T16339
1mg37.00€5mg111.00€10mg187.00€25mg315.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)116.00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Formula:C23H25FN6Purity:99.31%Color and Shape:SolidMolecular weight:404.48coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Formula:C20H20O6Purity:97.09%Color and Shape:SolidMolecular weight:356.37MCI826
CAS:MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model ofFormula:C22H28N2O3SPurity:98.73%Color and Shape:SolidMolecular weight:400.53Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purity:100% - 95%Color and Shape:SolidMolecular weight:1214.62Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formula:C24H30O7Purity:98.39%Color and Shape:SolidMolecular weight:430.49Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purity:n~9-10Color and Shape:Light Amber SemisolidMolecular weight:328.29775Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purity:99.73%Color and Shape:Crystalline SolidMolecular weight:410.48Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formula:C16H24NO5·CNSPurity:98.19% - ≥95%Color and Shape:SolidMolecular weight:368.45Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formula:C32H31N5O2Purity:98.65%Color and Shape:SolidMolecular weight:517.62Ref: TM-T12341
5mg50.00€10mg84.00€25mg150.00€50mg219.00€100mg304.00€200mg419.00€1mL*10mM (DMSO)58.00€Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Formula:C17H19NO3Purity:100% - 97.79%Color and Shape:SolidMolecular weight:285.34γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purity:97.27% - 98.13%Color and Shape:SolidMolecular weight:410.63Ref: TM-T19768
1mg47.00€2mg62.00€5mg92.00€10mg144.00€25mg235.00€50mg350.00€100mg515.00€200mg743.00€1mL*10mM (DMSO)97.00€Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Color and Shape:SolidMolecular weight:527.6Evodine
CAS:1. Evodine has antinociceptive activity.Formula:C18H19NO5Purity:98%Color and Shape:SolidMolecular weight:329.35Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purity:97.43% - 98.53%Color and Shape:SolidMolecular weight:374.34Ref: TM-TJS1159
1mg60.00€5mg127.00€10mg188.00€25mg348.00€50mg512.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)226.00€Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurity:100% - 99.55%Color and Shape:SolidMolecular weight:636.99PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formula:C26H23N3OPurity:98% - 98.53%Color and Shape:SolidMolecular weight:393.48Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurity:99.58%Color and Shape:SolidMolecular weight:401.47Ref: TM-T13383
1mg96.00€5mg205.00€10mg309.00€25mg557.00€50mg838.00€100mg1,216.00€1mL*10mM (DMSO)221.00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurity:98.3% - 99.46%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:407.5Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.42Ref: TM-T8596
1mg43.00€5mg88.00€10mg119.00€25mg250.00€50mg389.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)87.00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Formula:C43H52N4O5Purity:98.54%Color and Shape:SolidMolecular weight:704.9Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purity:98.74%Color and Shape:SoildMolecular weight:698.73YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formula:C37H35BrN4O3Purity:97.50%Color and Shape:SolidMolecular weight:663.6Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purity:98.07% - 99.17%Color and Shape:SolidMolecular weight:646.73Larotaxel
CAS:Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in breast and bladder cancer.Formula:C45H53NO14Purity:99.22%Color and Shape:SolidMolecular weight:831.9Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Formula:C39H40N6O10SPurity:99.84%Color and Shape:SolidMolecular weight:784.83Ref: TM-T11578L
2mg42.00€5mg62.00€10mg88.00€25mg155.00€50mg250.00€100mg393.00€500mg893.00€1mL*10mM (DMSO)74.00€Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purity:98.7% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:491.06Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formula:C38H52N6O7Purity:98% - 99.95%Color and Shape:Crystalline SolidMolecular weight:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H52N6O7·H2SO4Purity:99.31% - 99.40%Color and Shape:SolidMolecular weight:802.93Ref: TM-T0100
5mg47.00€10mg62.00€25mg95.00€50mg120.00€100mg180.00€200mg264.00€500mg449.00€1mL*10mM (DMSO)52.00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purity:98% - 99.85%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formula:C32H38N4OPurity:98.86%Color and Shape:SolidMolecular weight:494.67Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFormula:C34H35N3O7Purity:99.43%Color and Shape:SolidMolecular weight:597.66Ref: TM-T11071
1mg39.00€2mg50.00€5mg85.00€10mg125.00€25mg245.00€50mg472.00€100mg687.00€500mg1,444.00€1mL*10mM (DMSO)96.00€Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purity:99.05% - ≥95%Color and Shape:SolidMolecular weight:372.37P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purity:99.58%Color and Shape:SoildMolecular weight:512.55FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formula:C26H25NO4Purity:99.84%Color and Shape:SolidMolecular weight:415.48Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formula:C20H33N3O3Purity:98.80%Color and Shape:SolidMolecular weight:363.49Ref: TM-T21640
2mg35.00€5mg50.00€10mg96.00€25mg188.00€50mg329.00€100mg565.00€200mg818.00€1mL*10mM (DMSO)55.00€Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purity:99.53%Color and Shape:OilMolecular weight:454.6Ref: TM-T20656
10mg35.00€25mg51.00€50mg73.00€100mg96.00€200mg143.00€500mg230.00€1mL*10mM (DMSO)55.00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purity:98.03% - 98.91%Color and Shape:SolidMolecular weight:460.73Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43
