Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Products of "Sodium Channel"
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PF 05089771
CAS:PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.Formula:C18H12Cl2FN5O3S2Purity:99.03% - 99.42%Color and Shape:SolidMolecular weight:500.35λ-Cyhalothrin
CAS:λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.Formula:C23H19ClF3NO3Purity:99.94%Color and Shape:SolidMolecular weight:449.852,6-Dichlorohexanoic Acid
CAS:Controlled ProductFormula:C6H10Cl2O2Color and Shape:NeatMolecular weight:185.054-Descarboxamido Rufinamide 4-Methyl Ester
CAS:Controlled ProductApplications 4-Descarboxamido Rufinamide 4-Methyl Ester is an impurity in the synthesis of Rufinamide (R701550), an antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),Formula:C11H9F2N3O2Color and Shape:NeatMolecular weight:253.203-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS:Controlled ProductApplications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry. References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)Formula:C10H12ClNO3SColor and Shape:NeatMolecular weight:261.73(S)-(+)-Mepivacaine Hydrochloride
CAS:Controlled ProductImpurity Ripovacaine EP Impurity C Applications (S)-(+)-Mepivacaine Hydrochloride (Ripovacaine EP Impurity C) is an optical isomer of the local anesthetic Mepivacaine (M225060) that is slightly less active than its (-)-isomer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Luduena, F.P. et al.: Arch. Int. Pharmacodyn. Ther., 200, 359 (1972); Jeske, A.H. et al.: Meth. Find. Exp. Clin. Pharmacol., 3, 33 (1981);Formula:C15H22N2O·HClColor and Shape:NeatMolecular weight:282.809Orphenadrine
CAS:Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner,Formula:C18H23NOPurity:99.26% - 99.38%Color and Shape:SolidMolecular weight:269.38GX-585
CAS:GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.Formula:C24H25Cl2FN4O3SPurity:100% - 99.18%Color and Shape:SolidMolecular weight:539.45Benzamil
CAS:Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.Formula:C13H14ClN7OPurity:99.79%Color and Shape:SolidMolecular weight:319.75(+)-Kavain
CAS:(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.Formula:C14H14O3Purity:97% - ≥95%Color and Shape:White Fine PowderMolecular weight:230.26Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Formula:C18H28N2O·HClPurity:99.74%Color and Shape:White Crystalline PowderMolecular weight:324.892-(3-Bromopropyl)-1,2,4-triazolo-pyridin-3-one
CAS:Controlled ProductApplications Used in the preparation of bicycloamine derivatives as sodium channel inhibitors for treatment of pain, epilepsy and insomnia.Formula:C9H10BrN3OColor and Shape:NeatMolecular weight:256.1DSP-2230
CAS:DSP-2230 is a selective blocker of Nav1.7/Nav1.8.Formula:C20H20F3N5O2Purity:97.14%Color and Shape:SolidMolecular weight:419.4Ref: TM-T15174
1mg35.00€5mg70.00€10mg104.00€25mg216.00€50mg354.00€100mg567.00€200mg805.00€1mL*10mM (DMSO)78.00€Triamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formula:C12H11N7Purity:99.77%Color and Shape:Yellow Yellow SolidMolecular weight:253.26Ethacizine hydrochloride
CAS:Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.Formula:C22H28ClN3O3SPurity:98.08% - 98.08%Color and Shape:SolidMolecular weight:449.99Benzocaine N-Glucoside (alpha/beta mixture)
CAS:Controlled ProductStability Hygroscopic Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent. References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);Formula:C15H21NO7Color and Shape:NeatMolecular weight:327.33Rimeporide
CAS:Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Formula:C11H15N3O5S2Purity:97.66%Color and Shape:SolidMolecular weight:333.38Ref: TM-T5319
1mg48.00€2mg65.00€5mg96.00€10mg170.00€25mg378.00€50mg552.00€100mg787.00€1mL*10mM (DMSO)114.00€Zoniporide hydrochloride
CAS:Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).Formula:C17H17ClN6OPurity:98.93%Color and Shape:SolidMolecular weight:356.81Dyclonine hydrochloride
CAS:Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .Formula:C18H27NO2·HClPurity:99.35%Color and Shape:White Crystalline SolidMolecular weight:325.87N-Formylguanidine
CAS:Controlled ProductFormula:C2H5N3OColor and Shape:Off-WhiteMolecular weight:87.081
