Calcium Channel
Calcium channels are membrane proteins that regulate the flow of calcium ions into and out of cells, which is essential for various cellular functions, including muscle contraction, neurotransmitter release, and gene expression. Dysregulation of calcium channel activity is associated with conditions such as hypertension, cardiac arrhythmias, and neurological disorders. At CymitQuimica, we provide a wide selection of calcium channel modulators to support your research in cardiovascular health, neurobiology, and signal transduction.
Products of "Calcium Channel"
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2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride
CAS:Controlled ProductApplications 2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker. References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994); Argekar, A., et al.: J. Pharm. Biomed. Anal., 21, 1137 (2000);Formula:C31H34N2O5·HClColor and Shape:NeatMolecular weight:514.61+(36.46)4-Defluoro 2-Fluoro Flunarizine Dihydrochloride
CAS:Controlled ProductStability Hygroscopic Applications 4-Defluoro 2-Fluoro Flunarizine Dihydrochloride is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)Formula:C26H26F2N2HClColor and Shape:White SolidMolecular weight:404.4923646Amlodipine
CAS:Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.Formula:C20H25ClN2O5Purity:99.33% - 99.60%Color and Shape:Solid PowderMolecular weight:408.88Brompheniramine maleate
CAS:Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formula:C16H19BrN2·C4H4O4Purity:99.80%Color and Shape:Crystal PowderMolecular weight:435.31Hexadecylphosphoserine TFA
Hexadecylphosphoserine is a type of phospholipid molecule that incorporates a long-chain alkyl group (hexadecyl) and a phosphatidylserine group, granting it high affinity for cell membranes. This compound exhibits antitumor activity by modulating [Ca++]i and related signaling pathways, making it useful for breast cancer research.Formula:C21H41F3NO8PColor and Shape:SolidMolecular weight:523.52AChE/BChE-IN-21
CAS:AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.Formula:C38H54N4O4Color and Shape:SolidMolecular weight:630.86Bay K 8644
CAS:Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.Formula:C16H15F3N2O4Purity:99.41%Color and Shape:Yellow PowderMolecular weight:356.3Norfluoxetine Hydrochloride
CAS:Norfluoxetine Hydrochloride (Norfluoxetine HCl) is an active metabolite of fluoxetine. Fluoxetine is an antidepressant drug.Formula:C16H17ClF3NOPurity:99.75%Color and Shape:SolidMolecular weight:331.76Ref: TM-T21029
1mg48.00€5mg135.00€10mg205.00€25mg369.00€50mg502.00€100mg727.00€200mg1,017.00€1mL*10mM (DMSO)99.00€Pranidipine
CAS:Applications A novel calcium channel antagonist; cardiovascular agent. References Matsumori, A., et al.: Circulation, 66, 355 (1982), Roberts, W., et al.: Am. J. Cardiol., 60, 1340 (1987), Uehara, Y., et al.: J. Cardiovasc. Pharmacol., 23, 970 (1994), Kim, C., et al.: Cardiovasc. Drugs Ther., 13, 455 (1999), Watanabe, K., et al.: Br. J. Pharmacol., 130, 1489 (2000),Formula:C25H24N2O6Color and Shape:NeatMolecular weight:448.47Cinnarizine
CAS:Cinnarizine is a piperazine, blocks H1-receptor & Ca-channels, has vasodilating & antiemetic effects, may cause Parkinson-like symptoms.Formula:C26H28N2Purity:99.94%Color and Shape:SolidMolecular weight:368.51cis Lacidipine
CAS:Controlled ProductStability Light Sensitive Applications Z-Isomer of Lacidipine; a dihydropyridine calcium channel blocker. Antihypertensive. References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),Formula:C26H33NO6Color and Shape:NeatMolecular weight:455.54Lifarizine
CAS:Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.Formula:C29H32N4Purity:99.12%Color and Shape:SolidMolecular weight:436.59Ranolazine
CAS:Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.Formula:C24H33N3O4Purity:98.13%Color and Shape:White SolidMolecular weight:427.541-[(2-Chlorophenyl)phenylmethyl]piperazine
CAS:Controlled ProductApplications 1-[(2-Chlorophenyl)phenylmethyl]piperazine is a novel compound derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one). References Maggi, C., et al.: Neuroscience, 34, 243 (1990), Evans, A., et al.: Brain Res., 712, 265 (1996), Kerr, L., et al.: Eur. J. Pharmacol., 146, 181 (1998), Hu, L., et al.: Bioorg. Med. Chem. Lett., 9, 907 (1999),Formula:C16H28N2O11Color and Shape:NeatMolecular weight:424.4ML218
CAS:ML218 is an inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3).ML218 inhibits the synaptic activity of subthalamic nucleus (STN) neurons.Formula:C19H26Cl2N2OPurity:99.2% - 99.45%Color and Shape:SolidMolecular weight:369.33Lercanidipine hydrochloride
CAS:Lercanidipine hydrochloride (Corifeo) is a calcium channel blocker of the dihydropyridine class.Formula:C36H41N3O6·HClPurity:100% - 99.86%Color and Shape:Pale-Yellow PowderMolecular weight:648.19Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purity:99.53%Color and Shape:OilMolecular weight:454.6Ref: TM-T20656
10mg35.00€25mg51.00€50mg73.00€100mg96.00€200mg143.00€500mg230.00€1mL*10mM (DMSO)55.00€Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Formula:C23H14Na2O11Purity:98.25% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33MP-010
CAS:MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.Formula:C14H20N4O2SColor and Shape:SolidMolecular weight:308.399Topiramate
CAS:Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.Formula:C12H21NO8SPurity:99.79% - 99.92%Color and Shape:White To Off-White Crystalline PowderMolecular weight:339.36Dehydro Amlodipine Besylate
CAS:Controlled ProductApplications Dehydro Amlodipine Besylate is an impurity of Amlodipine (A633495), a dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer. References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)Formula:C2023ClN2O5·C6H6O3SColor and Shape:NeatMolecular weight:565.04Nepetin
CAS:Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.Formula:C16H12O7Purity:99.91% - 99.96%Color and Shape:SolidMolecular weight:316.26Ref: TM-TN1154
1mg70.00€5mg160.00€10mg250.00€25mg424.00€50mg612.00€100mg842.00€1mL*10mM (DMSO)212.00€Gabapentin
CAS:Gabapentin (Neurontin) is an Anti-epileptic Agent.Formula:C9H17NO2Purity:99.55% - 99.91%Color and Shape:White To Off-White Crystalline Solid; Crystals From Ethanol/Ether SolidMolecular weight:171.24TPC2-A1-P
CAS:TPC2-A1-P is a TPC2 agonist that can differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP (2).Formula:C20H21BrF3NO3Purity:98.49%Color and Shape:SolidMolecular weight:460.29Ref: TM-T36806
1mg97.00€5mg236.00€10mg394.00€25mg750.00€50mg1,216.00€100mg1,853.00€1mL*10mM (DMSO)240.00€VU 0240551
CAS:VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.Formula:C16H14N4OS2Purity:99.72%Color and Shape:SolidMolecular weight:342.44Ref: TM-TQ0139
1mg37.00€5mg78.00€10mg125.00€25mg255.00€50mg439.00€100mg705.00€200mg938.00€500mg1,415.00€1mL*10mM (DMSO)86.00€Norbormide
CAS:Controlled ProductApplications Norbormide is used as a rodenticide. It acts as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria. References Rennison, D., et al.: Bioorg. Med. Chem., 15, 2963 (2007); Zulian, A., et al.: Biochimica et Biophysica Acta, 1767, 980 (2007)Formula:C33H25N3O3Color and Shape:White To Off-WhiteMolecular weight:511.57SEA0400
CAS:SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.Formula:C21H19F2NO3Purity:98.11% - 99.29%Color and Shape:SolidMolecular weight:371.38Ref: TM-T3508
1mg39.00€2mg50.00€5mg81.00€10mg131.00€25mg230.00€50mg378.00€100mg567.00€500mg1,254.00€1mL*10mM (DMSO)74.00€NAADP sodium
NAADP sodium is a Ca2+ motor second messenger that targets Ca(2+) channels and can be used to study cancer and immune dysfunction.Formula:C21H27N6O18P3Color and Shape:SolidMolecular weight:744.39JTV-519
CAS:K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) byFormula:C25H33ClN2O2SPurity:99.8%Color and Shape:SolidMolecular weight:461.06Ref: TM-T24239
1mg60.00€5mg110.00€10mg155.00€25mg248.00€50mg365.00€100mg545.00€500mg1,188.00€1mL*10mM (DMSO)134.00€(3-(tert-Butyl)-1H-pyrazol-5-yl)methanol
CAS:Controlled ProductApplications (3-(tert-butyl)-1H-pyrazol-5-yl)methanol (cas# 493038-53-2) is a useful research chemical.Formula:C8H14N2OColor and Shape:White To Off-WhiteMolecular weight:154.21Almorexant
CAS:Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.Formula:C29H31F3N2O3Purity:97.75% - 98.02%Color and Shape:SolidMolecular weight:512.56d-Glaucine-d6
CAS:Controlled ProductApplications d-Glaucine-d6 is labelled d-Glaucine (G406900) which has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. References Cortijo, J., et al.: Brit. J. Pharm., 127, 1641 (1999); Rühle, K., et al.: Brit. J. Clin. Pharm., 17, 521 (1984)Formula:C21H19D6NO4Color and Shape:NeatMolecular weight:361.46Ginsenoside Ro
CAS:Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist withFormula:C48H76O19Purity:98% - 99.8%Color and Shape:SolidMolecular weight:957.11BBT
CAS:BBT has anti-hyperglycemic activity, protecting beta cells from cytokine or streptozotocin-induced cell death, and restoring beta cell function.Formula:C18H12BrNO2SPurity:99.02%Color and Shape:SolidMolecular weight:386.26Ambocin
CAS:Ambocin is a natural product from Pueraria mirifica.Formula:C26H28O14Purity:98%Color and Shape:SolidMolecular weight:564.49N-Desmethyl-N-acetyl Diltiazem
Controlled ProductApplications N-Desmethyl-N-acetyl Diltiazem is a metabolite of Diltiazem (D460620, HCl); a calcium channel blocker with vasodilating activity. Also anti-anginal, anti-hypertensive, and anti-arrhythmic (class IV). References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)Formula:C23H26N2O5SColor and Shape:NeatMolecular weight:442.53ORM-10962
CAS:ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55Formula:C27H29N3O4Purity:98%Color and Shape:SolidMolecular weight:459.54Levamlodipine besylate Hemipentahydrate
CAS:Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.Formula:C20H25ClN2O5·C6H6O3SH2OColor and Shape:SolidMolecular weight:1224.18Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFormula:C36H67N11O8S2Purity:98%Color and Shape:SolidMolecular weight:846.122-(3-Chlorophenyl)-2-methylpropan-1-amine
CAS:Controlled ProductApplications 2-(3-Chlorophenyl)-2-methylpropan-1-amine was used for the preparation of pyrimidinediones as antagonists of L-type calcium channels (LTCC) for potential use in the treatment of Parkinson’s disease. References Kang, S., et al.: J. Med. Chem., 56, 4786-4797 (2013)Formula:C10H14ClNColor and Shape:NeatMolecular weight:183.68GV-58
CAS:GV-58 agonizes N/P-Q-type Ca2+ channels (EC50: 7.21/8.81 μM) with 20x less inhibition on CDK kinases.Formula:C18H26N6OSPurity:97.36%Color and Shape:SolidMolecular weight:374.5Ref: TM-T11517
1mg51.00€5mg144.00€10mg216.00€25mg432.00€50mg625.00€100mg873.00€500mg1,738.00€1mL*10mM (DMSO)159.00€trans-Ned 19
CAS:trans-Ned 19 blocks NAADP and TPC, hindering calcium signaling and aorta relaxation at low histamine levels.Formula:C30H31FN4O3Purity:98%Color and Shape:SolidMolecular weight:514.59Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Formula:C33H34N4O6Purity:99.28%Color and Shape:Light Yellowish PowderMolecular weight:582.65Ref: TM-T0121
5mg50.00€10mg67.00€25mg109.00€50mg172.00€100mg309.00€200mg500.00€500mg800.00€1mL*10mM (DMSO)74.00€1,2,4-Trihydroxybenzene
CAS:1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) is a by-product of coffee bean roasting and is found in mouse, arabica coffee.1,2,4-Trihydroxybenzene is aFormula:C6H6O3Purity:97.16%Color and Shape:SolidMolecular weight:126.11Lercanidipine-d3 Hydrochloride
CAS:Controlled ProductFormula:C36D3H38N3O6·HClColor and Shape:NeatMolecular weight:651.21Nicardipine O-Desmethyl-O-methyl(phenylmethyl)amino]ethyl) Ester Hydrochloride
CAS:Applications Nicardipine (N394500) impurity. Nicardipine is a dihydropyridine calcium channel blocker. Antianginal; antihypertensive. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Satoh, K., et al.: Clin. Exp. Pharmacol. Physiol., 7, 249 (1980), Sorkin, E.M., et al.: Drugs, 33, 296 (1987),Formula:C35H40N4O6·x(HCl)Color and Shape:NeatMolecular weight:612.723646Gallopamil hydrochloride
CAS:Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium.Formula:C28H41ClN2O5Purity:99.02%Color and Shape:SolidMolecular weight:521.09Ref: TM-T11353L
1mg38.00€5mg73.00€10mg90.00€25mg140.00€50mg183.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)90.00€Diproteverine HCl
CAS:Diproteverine HCl is a novel calcium antagonist with antianginal properties, antispasmodic and vasoactive.Formula:C26H36ClNO4Purity:99.38% - 99.44%Color and Shape:SolidMolecular weight:462.02JTV-519 fumarate
CAS:Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.Formula:C29H36N2O6SColor and Shape:SolidMolecular weight:540.67
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