Calcium Channel

Psoralenoside: a compound from Psoralea fruit; has estrogenic, osteoblastic, antitumor, and antibacterial properties.

TTA-A8 is an antagonist of T-type calcium channel.

Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling

CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity and

Applications N-Piperidinyl acetamide derivatives as calcium channel blockers and their use in the treatment of obesity. References Lopez-Rodriguez, et al.: Bioorg. Med. Chem. Lett., 11, 2807 (2001), Yang, et al.: J. Med. Chem., 51, 6471 (2008),

Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.

SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM

(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.

Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways.

Applications Labelled Diltiazem (D460620). A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV). References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Gallopamil blocks acid secretion (IC50: 10.9 μM), acts as antiarrhythmic, vasodilator, and is a methoxy Verapamil derivative.

Impurity Nisoldipine Applications Dehydronitrosonisoldipine is an impurity of Nisoldipine (N489125). Nisoldipine is a dihydropyridine calcium channel blocker and it is antihypertensive and antianginal. References Kazda, S., et al.: Arzneimittel-Forsch., 30, 2144 (1980); Pasanisi, F., et al.: Eur. J. Clin. Pharmacol., 29, 21 (1985); Lam, J., et al.: J. Am. Col. Cardiol., 6, 447 (1985)

BTT-266 is a blocker of voltage-gated calcium channel for pain management.

Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.

Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.

Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.

Applications α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol is an intermediate in the synthesis of Norbormide (N661150), a rodenticide that acts as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria. References Rennison, D., et al.: Bioorg. Med. Chem. 15, 2963 (2007);

Stability Light and Moisture Sensitive Applications Isotope Labelled analogue of rac-Kavain (K145490), the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles. References Gleitz, J., et al: Neuropharmacol., 35, 1743 (1997); Hashimoto, T., et al.: Phytomedicine, 10, 309 (2003); Mulholland, P.J., et al.: Brain. Res., 945, 106 (2002);