PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formula:C21H15ClF3NO2Purity:98.20%Color and Shape:SolidMolecular weight:405.8Ref: TM-T10590
1mg70.00€5mg135.00€10mg245.00€25mg409.00€50mg562.00€100mg780.00€200mg1,026.00€1mL*10mM (DMSO)149.00€Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Formula:C23H24F2N2O5Purity:99.04%Color and Shape:SolidMolecular weight:446.44Ref: TM-T27172
1mg69.00€5mg149.00€10mg235.00€25mg469.00€50mg753.00€100mg1,216.00€1mL*10mM (DMSO)164.00€Vardenafil hydrochloride
CAS:Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With DiabetesFormula:C23H33ClN6O4SPurity:99.76% - 99.86%Color and Shape:White To Off-White Cyrstalline SolidMolecular weight:525.06TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurity:98.48%Color and Shape:SolidMolecular weight:460.45Ref: TM-T13189
1mg92.00€2mg120.00€5mg187.00€10mg279.00€25mg487.00€50mg705.00€100mg998.00€500mg1,882.00€1mL*10mM (DMSO)188.00€Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Formula:C30H30Cl2F2N2O8SPurity:98.3%Color and Shape:SolidMolecular weight:687.54PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Formula:C18H14N4SPurity:100%Color and Shape:SolidMolecular weight:318.4K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Formula:C25H26FN5O2Purity:99.48%Color and Shape:SolidMolecular weight:447.5Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Formula:C14H13N3O2SPurity:99.12%Color and Shape:SolidMolecular weight:287.34Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Formula:C20H27N5O2Purity:99.58% - 99.90%Color and Shape:Off-White SolidMolecular weight:369.46Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Formula:C15H15N3OPurity:99.11%Color and Shape:SolidMolecular weight:253.3EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formula:C22H23N3O4SPurity:98% - 99.38%Color and Shape:SolidMolecular weight:425.5MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Formula:C25H18N4O3Purity:99.29%Color and Shape:SolidMolecular weight:422.44Anagrelide hydrochloride
CAS:Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.Formula:C10H7Cl2N3O·HClPurity:99.58%Color and Shape:Off-White PowderMolecular weight:292.55Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Formula:C20H13Cl2F2N3O5SPurity:98.11%Color and Shape:SolidMolecular weight:516.3Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Color and Shape:Odour LiquidTAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purity:99.70%Color and Shape:SolidMolecular weight:251.05Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Formula:C21H15Cl2F2N3O2SPurity:98.84%Color and Shape:SolidMolecular weight:482.33Ref: TM-T63190
1mg77.00€5mg170.00€10mg248.00€25mg444.00€50mg662.00€100mg929.00€200mg1,225.00€1mL*10mM (DMSO)170.00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurity:99.34% - 99.94%Color and Shape:White SolidMolecular weight:230.31Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Formula:C15H22ClN5O4SPurity:100%Color and Shape:SoildMolecular weight:403.88Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Formula:C22H30N6O4S·xCH4O3SPurity:99.84%Color and Shape:SolidMolecular weight:570.68Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Formula:C17H14Cl2F2N2O4Purity:99.55% - 99.65%Color and Shape:SolidMolecular weight:419.21Ref: TM-T4462
1mg35.00€2mg52.00€5mg74.00€10mg99.00€25mg170.00€50mg274.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)69.00€PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Formula:C22H18ClF2N3O2SPurity:98%Color and Shape:SolidMolecular weight:461.912-(Hydroxymethyl)pyridine
CAS:2-(Hydroxymethyl)pyridine (Piconol) is an intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.Formula:C6H7NOPurity:99.79%Color and Shape:Clear Light Yellow To Orange Liquid LiquidMolecular weight:109.13Zaprinast
CAS:Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist.Formula:C13H13N5O2Purity:99.73% - 99.77%Color and Shape:White To Off White PowderMolecular weight:271.27Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Formula:C20H26N2O3Purity:98.87%Color and Shape:White To Off-White SolidMolecular weight:342.43Irsogladine
CAS:Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.Formula:C9H7Cl2N5Purity:99.74% - 99.91%Color and Shape:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterMolecular weight:256.09uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Formula:C26H24F3N3O4Purity:99.90%Color and Shape:SolidMolecular weight:499.48Ref: TM-T67815
1mg159.00€5mg380.00€10mg570.00€25mg912.00€50mg1,216.00€100mg1,663.00€500mg3,315.00€1mL*10mM (DMSO)470.00€AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Formula:C22H14Cl2FN3O3Purity:99.55% - 99.95%Color and Shape:SolidMolecular weight:458.27Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFormula:C19H31N7O4Purity:99.42% - 99.51%Color and Shape:SolidMolecular weight:421.49Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purity:99.45%Color and Shape:SolidMolecular weight:313.74Ref: TM-T21965
5mg47.00€10mg80.00€25mg145.00€50mg233.00€100mg335.00€200mg467.00€1mL*10mM (DMSO)49.00€Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Formula:C18H21N5SPurity:99.94%Color and Shape:SolidMolecular weight:339.46Mirodenafil
CAS:Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Formula:C26H37N5O5SPurity:99.89%Color and Shape:SolidMolecular weight:531.67Ref: TM-T16079
2mg35.00€5mg52.00€10mg79.00€25mg134.00€50mg210.00€100mg338.00€200mg497.00€1mL*10mM (DMSO)60.00€ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Formula:C27H28FN3O3Purity:97.05%Color and Shape:SolidMolecular weight:461.53Ref: TM-T38759
1mg156.00€5mg368.00€10mg509.00€25mg770.00€50mg1,035.00€100mg1,396.00€200mg1,882.00€1mL*10mM (DMSO)409.00€Dipyridamole
CAS:Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.Formula:C24H40N8O4Purity:99.47% - 99.84%Color and Shape:SolidMolecular weight:504.63Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Formula:C24H19BFNO5SPurity:98.28%Color and Shape:SolidMolecular weight:463.29Ref: TM-T11533
1mg49.00€2mg65.00€5mg97.00€10mg154.00€25mg298.00€50mg487.00€100mg692.00€1mL*10mM (DMSO)106.00€Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Formula:C19H18N4O2Purity:99.91%Color and Shape:SolidMolecular weight:334.37Ref: TM-T1708
2mg38.00€5mg60.00€10mg87.00€25mg162.00€50mg274.00€100mg406.00€500mg920.00€1mL*10mM (DMSO)66.00€Sulmazole
CAS:Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Formula:C14H13N3O2SPurity:99.64%Color and Shape:SolidMolecular weight:287.34D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Formula:C21H19ClN2O2Purity:97.57%Color and Shape:SolidMolecular weight:366.84Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Formula:C18H24N4O4Purity:97.28%Color and Shape:SolidMolecular weight:360.41Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Formula:C28H31F6NO3Color and Shape:SolidMolecular weight:543.54Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Formula:C16H17N5O2Purity:99.93%Color and Shape:SolidMolecular weight:311.34Ref: TM-T8515
1mg38.00€2mg50.00€5mg81.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€200mg748.00€1mL*10mM (DMSO)89.00€PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFormula:C20H23ClN4O2Purity:98.57%Color and Shape:SolidMolecular weight:386.88Ref: TM-T10201
1mg341.00€5mg723.00€10mg969.00€25mg1,454.00€50mg1,948.00€100mg2,632.00€1mL*10mM (DMSO)815.00€ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Color and Shape:Lyophilized PowderMolecular weight:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Color and Shape:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purity:98.98%Color and Shape:SolidMolecular weight:375.34Ref: TM-T9239
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)187.00€ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurity:99.23%Color and Shape:SolidMolecular weight:474.87Ref: TM-T10409
1mg64.00€5mg140.00€10mg219.00€25mg373.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)145.00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:322.77IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFormula:C10H14N4O2Purity:100% - 99.99%Color and Shape:Off-WhiteMolecular weight:222.24GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFormula:C27H26N4O5SPurity:99.52% - 99.66%Color and Shape:SolidMolecular weight:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purity:100%Color and Shape:SolidMolecular weight:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purity:98%Color and Shape:SolidMolecular weight:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Formula:C18H20ClN5OPurity:98.75%Color and Shape:SolidMolecular weight:357.84Ref: TM-T28352
1mg39.00€5mg73.00€10mg94.00€25mg153.00€50mg219.00€100mg325.00€200mg465.00€1mL*10mM (DMSO)84.00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Formula:C16H14N4OPurity:100% - 99.61%Color and Shape:SolidMolecular weight:278.31Ref: TM-T23638
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mgTo inquire1mL*10mM (DMSO)240.00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Formula:C19H17ClN2O2Purity:100%Color and Shape:SolidMolecular weight:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Formula:C26H24N4O5Purity:97.03% - 99.29%Color and Shape:SolidMolecular weight:472.49Ref: TM-T3987
1mg34.00€2mg47.00€5mg70.00€10mg96.00€25mg170.00€50mg298.00€100mg430.00€200mg607.00€1mL*10mM (DMSO)71.00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurity:100% - ≥95%Color and Shape:SolidMolecular weight:463.29Ref: TM-T2646
2mg39.00€5mg57.00€10mg93.00€25mg145.00€50mg235.00€100mg351.00€200mg528.00€1mL*10mM (DMSO)58.00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurity:99.02%Color and Shape:White SolidMolecular weight:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Formula:C19H18ClN3O2SPurity:99.37%Color and Shape:SolidMolecular weight:387.88Ref: TM-T36832
1mg37.00€5mg79.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:98.92%Color and Shape:SolidMolecular weight:463.29PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Formula:C20H25N7O2Purity:99.11% - 99.11%Color and Shape:SolidMolecular weight:395.46Naproxen etemesil
CAS:Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.Formula:C17H20O5SPurity:98%Color and Shape:SolidMolecular weight:336.4CRT0273750
CAS:CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.Formula:C25H22ClF3N4O2Purity:99.49%Color and Shape:SolidMolecular weight:502.92Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Formula:C11H10ClN3OPurity:99.21% - 99.67%Color and Shape:SolidMolecular weight:235.67Ref: TM-T9871
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg475.00€100mg638.00€200mg845.00€1mL*10mM (DMSO)138.00€BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Formula:C28H31F6NO3Purity:98.03%Color and Shape:SolidMolecular weight:543.54Ref: TM-T10545
1mg221.00€5mg550.00€10mg905.00€25mg1,890.00€50mg3,030.00€100mg4,874.00€1mL*10mM (DMSO)35.00€Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formula:C12H9N3OPurity:99.22% - 99.92%Color and Shape:SolidMolecular weight:211.22
