Glucokinase
Glucokinase (GK) is an enzyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. GK is predominantly expressed in the liver and pancreas, where it plays a key role in regulating blood glucose levels. Inhibitors of GK are of interest in the study of metabolic disorders such as diabetes, as they can modulate glucose metabolism and insulin secretion. At CymitQuimica, we provide glucokinase inhibitors to support your research in diabetes, metabolism, and therapeutic development.
Products of "Glucokinase"
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Found 40 products on this category.
AM-2394
CAS:AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.Formula:C22H25N5O4Purity:99.01% - 99.62%Color and Shape:SolidMolecular weight:423.46AP-III-a4
CAS:AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.Formula:C31H43FN8O3Purity:98.24% - 99.90%Color and Shape:SolidMolecular weight:594.72Ref: TM-T6759
1mg51.00€5mg127.00€10mg205.00€25mg378.00€50mg620.00€100mg1,026.00€200mg1,388.00€1mL*10mM (DMSO)166.00€RO-28-1675
CAS:RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.Formula:C18H22N2O3S2Purity:99.41%Color and Shape:SolidMolecular weight:378.51Ref: TM-T16793
1mg89.00€5mg212.00€10mg365.00€25mg602.00€50mg847.00€100mg1,121.00€200mg1,539.00€1mL*10mM (DMSO)233.00€Globalagliatin
CAS:Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.Formula:C28H37N3O3S3Purity:98% - 99.41%Color and Shape:SolidMolecular weight:559.81Anti-Glucokinase Antibody (5Q209)
Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.Color and Shape:Odour LiquidGlucokinase activator 8
CAS:Glucokinase activator8 is an activator of glucose kinase (glucokinase).Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337Gcase activator 2
CAS:Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.Formula:C21H24N4O2Purity:99.51% - 99.79%Color and Shape:SolidMolecular weight:364.44AZD-1656
CAS:AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2Formula:C24H26N6O5Purity:99.37%Color and Shape:SolidMolecular weight:478.5ADP-specific glucokinase
CAS:ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.Color and Shape:SolidGlucokinase activator 7
CAS:Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337Dorzagliatin
CAS:Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.Formula:C22H27ClN4O5Purity:98.52% - 98.67%Color and Shape:SolidMolecular weight:462.93Ref: TM-T15159
1mg40.00€2mg52.00€5mg87.00€10mg123.00€25mg240.00€50mg378.00€100mg567.00€1mL*10mM (DMSO)95.00€AP-III-a4 hydrochloride
CAS:AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.Formula:C31H44ClFN8O3Purity:98%Color and Shape:SolidMolecular weight:631.18Ref: TM-T6759L
2mg97.00€5mg178.00€10mg286.00€25mg588.00€50mg830.00€100mgTo inquire200mgTo inquire1mL*10mM (DMSO)248.00€WAY-640509
CAS:WAY-640509 is a glucocerebrosidase inhibitor.Formula:C25H23N5O4SPurity:98.59%Color and Shape:SolidMolecular weight:489.55Ref: TM-T60048
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€500mg2,157.00€Genz-123346 free base
CAS:Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.Formula:C24H38N2O4Purity:99.41%Color and Shape:SolidMolecular weight:418.57Cefetrizole
CAS:Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).Formula:C16H15N5O4S3Purity:98%Color and Shape:SolidMolecular weight:437.52Glucosylsphingosine
CAS:Glucosylsphingosine (Lyso-Gb1) is a glycosyl ceramide that accumulates in neurodegenerative disorders and disrupts lysosomal function by activating mTORC1.Formula:C24H47NO7Color and Shape:SolidMolecular weight:461.63Anti-Glucokinase Antibody (3U461)
Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.Color and Shape:Odour LiquidPF-04991532
CAS:PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.Formula:C18H19F3N4O3Purity:98%Color and Shape:SolidMolecular weight:396.36(1S,2R)-Globalagliatin
CAS:(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.Formula:C28H37N3O3S3Purity:98.31% - 99.00%Color and Shape:SoildMolecular weight:559.81PF-04937319
CAS:PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.Formula:C22H20N6O4Purity:98.61%Color and Shape:SolidMolecular weight:432.43Oxfendazole
CAS:Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.Formula:C15H13N3O3SPurity:98.81% - 98.99%Color and Shape:White To Yellowish PowderMolecular weight:315.35MitoPQ
CAS:MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.Formula:C39H46I3N2PPurity:≥98%Color and Shape:SolidMolecular weight:954.48AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Formula:C23H30F3N3O4S2Purity:97.97%Color and Shape:SolidMolecular weight:533.63POMHEX
CAS:Pomhex, a cell-penetrating ENO2 inhibitor, thwarts glycolysis to combat ENO1-deficient tumors.Formula:C17H30NO9PPurity:99.88%Color and Shape:SolidMolecular weight:423.4AMG-3969
CAS:AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).Formula:C21H20F6N4O3SPurity:99.65%Color and Shape:SolidMolecular weight:522.46Ref: TM-TQ0055
1mg120.00€5mg235.00€10mg369.00€25mg612.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)269.00€ML251
CAS:ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.Formula:C17H13Cl2N3O4SPurity:99.87%Color and Shape:SolidMolecular weight:426.27Ref: TM-T64320
1mg133.00€5mg274.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€500mg2,717.00€1mL*10mM (DMSO)301.00€AZ PFKFB3 26
CAS:AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.Formula:C24H26N4O2Purity:98.91%Color and Shape:SolidMolecular weight:402.49ARRY-403
CAS:ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.Formula:C20H18N6O3S2Purity:98.69%Color and Shape:SolidMolecular weight:454.52Glucokinase Protein, Human, Recombinant
Glucokinase belongs to the bacterial glucokinase family.Color and Shape:Lyophilized PowderMolecular weight:52.2 kDa (predicted); 52.2 kDa (reducing conditions)WAY-297848
CAS:WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.Formula:C13H13ClN2O2SPurity:98.19%Color and Shape:SolidMolecular weight:296.77KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.Formula:C21H18FNO7SPurity:99.34%Color and Shape:SolidMolecular weight:447.43Ref: TM-T11741
1mg101.00€5mg192.00€10mg306.00€25mg553.00€50mg760.00€100mg1,035.00€1mL*10mM (DMSO)207.00€MK-0941 free base
CAS:MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.Formula:C21H24N4O6SPurity:98.75%Color and Shape:SolidMolecular weight:460.5Ref: TM-T12056
1mg87.00€5mg172.00€10mg258.00€25mg425.00€50mg598.00€100mg810.00€1mL*10mM (DMSO)208.00€KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formula:C25H26N6OPurity:98%Color and Shape:SolidMolecular weight:426.51ML198
CAS:ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.Formula:C17H14N4OPurity:98.31%Color and Shape:SolidMolecular weight:290.32YZ9
CAS:Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].Formula:C12H10O5Purity:99.13%Color and Shape:SolidMolecular weight:234.2PFK-015
CAS:PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).Formula:C17H12N2OPurity:98.94% - 99.7%Color and Shape:SolidMolecular weight:260.29Ref: TM-T2455
5mg57.00€10mg88.00€25mg159.00€50mg283.00€100mg419.00€200mg582.00€500mg928.00€1mL*10mM (DMSO)57.00€Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Formula:C16H30O2Purity:99.36%Color and Shape:SolidMolecular weight:254.41ML266
CAS:ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.Formula:C24H22BrN3O4Purity:98.45%Color and Shape:SolidMolecular weight:496.35Ref: TM-T8990
1mg52.00€2mg74.00€5mg111.00€10mg170.00€25mg344.00€50mg474.00€100mg688.00€500mg1,444.00€1mL*10mM (DMSO)120.00€(E)-3PO
CAS:(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.Formula:C13H10N2OPurity:98.8% - 98.8%Color and Shape:SolidMolecular weight:210.23Ref: TM-T3260
1mg35.00€2mg48.00€5mg66.00€10mg93.00€25mg162.00€50mg284.00€100mg510.00€1mL*10mM (DMSO)66.00€3PO
CAS:3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.Formula:C13H10N2OPurity:97.76% - 99.67%Color and Shape:SolidMolecular weight:210.23Ref: TM-T22223
5mg57.00€10mg81.00€25mg127.00€50mg188.00€100mg340.00€200mg507.00€500mg807.00€1mL*10mM (DMSO)64.00€
