HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Products of "HIF/HIF Prolyl-Hydroxylase"
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TC-S 7009
CAS:TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Formula:C12H6ClFN4O3Purity:100% - 99.71%Color and Shape:SolidMolecular weight:308.65PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54Tilorone dihydrochloride
CAS:Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Formula:C25H36Cl2N2O3Purity:98% - 99.86%Color and Shape:Orange Yellow Crystal PowderMolecular weight:483.47SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Formula:C18H16O3SPurity:98.31%Color and Shape:SolidMolecular weight:312.38Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Formula:C17H16N4O4Purity:99.14% - 99.61%Color and Shape:SolidMolecular weight:340.33Ref: TM-T15219
1mg39.00€2mg50.00€5mg79.00€10mg115.00€25mg188.00€50mg311.00€100mg462.00€1mL*10mM (DMSO)90.00€HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Formula:C18H15N3O2Purity:98.20%Color and Shape:SolidMolecular weight:305.33Ref: TM-T15396
1mg70.00€5mg135.00€10mg188.00€25mg325.00€50mg465.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)149.00€2,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Formula:C11H13NO4Purity:99.74%Color and Shape:Yellow Solid CrystallineMolecular weight:223.23Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.17ZK-261991
CAS:ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Formula:C24H25N7O2Purity:98%Color and Shape:SolidMolecular weight:443.5Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Formula:C16H16N2O6Purity:98%Color and Shape:SolidMolecular weight:332.31Ref: TM-T5176
1mg35.00€2mg52.00€5mg94.00€10mg167.00€25mg300.00€50mg516.00€100mg732.00€1ml*10 (DMSO)112.00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formula:C17H12F3NO4SPurity:99.34% - 99.41%Color and Shape:SolidMolecular weight:383.34Ref: TM-T16679
1mg70.00€5mg153.00€10mg216.00€25mg411.00€50mg660.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)166.00€DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Formula:C18H19IN2O2Purity:99.17%Color and Shape:SolidMolecular weight:422.26Ref: TM-T67767
1mg48.00€5mg96.00€10mg157.00€25mg281.00€50mg454.00€100mg702.00€200mg938.00€1mL*10mM (DMSO)116.00€IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Formula:C23H32N2O2Purity:98.05%Color and Shape:SolidMolecular weight:368.51Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFormula:C6H13Li3O11Purity:≥95%Color and Shape:White Crystalline PowderMolecular weight:281.98IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Formula:C19H16N2O5Purity:98% - 99.59%Color and Shape:SolidMolecular weight:352.34Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Formula:C15H13N3O2SPurity:99.74%Color and Shape:White To Yellowish PowderMolecular weight:299.35Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93Ref: TM-T64336
5mg46.00€10mg64.00€25mg109.00€50mg170.00€100mg273.00€200mg399.00€1mL*10mM (DMSO)49.00€HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Formula:C32H61N3O10P2Purity:98%Color and Shape:SolidMolecular weight:709.79HIF-2α-IN-2
CAS:HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Formula:C17H13F2NO4SPurity:99.24%Color and Shape:SolidMolecular weight:365.35Ref: TM-T11561
1mg71.00€5mg135.00€10mg178.00€25mg309.00€50mg447.00€100mg620.00€200mg835.00€1mL*10mM (DMSO)149.00€JPHM-2-167
CAS:PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formula:C12H6ClN5O5Purity:98.11%Color and Shape:SolidMolecular weight:335.66Ref: TM-T11562
1mg115.00€5mg274.00€10mg432.00€25mg845.00€50mg1,293.00€100mg1,768.00€1mL*10mM (DMSO)303.00€HNHA
CAS:HNHA is an inhibitor of HDAC.Formula:C17H21NO2SPurity:98.04%Color and Shape:SolidMolecular weight:303.42Ref: TM-T21806
1mg44.00€5mg84.00€10mg135.00€25mg279.00€50mg445.00€100mg640.00€200mg879.00€1mL*10mM (DMSO)90.00€Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurity:98.45%Color and Shape:SolidMolecular weight:361.46HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formula:C13H8Br2N2O2SPurity:98.32%Color and Shape:SoildMolecular weight:416.09Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formula:C12H15N3O2SPurity:98.21% - 98.76%Color and Shape:Colorless Crystals SolidMolecular weight:265.33JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formula:C12H6ClF3N4O3Purity:99.58% - ≥95%Color and Shape:SolidMolecular weight:346.65Ref: TM-T3180
1mg40.00€2mg52.00€5mg88.00€10mg119.00€25mg210.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formula:C17H10F5NO4SPurity:98.8% - 99.07%Color and Shape:SolidMolecular weight:419.32Ref: TM-T12675L
1mg99.00€5mg235.00€10mg354.00€25mg640.00€50mg944.00€100mg1,320.00€1mL*10mM (DMSO)259.00€ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Formula:C27H21N5Purity:99.03%Color and Shape:SolidMolecular weight:415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFormula:C28H37FN4O4SPurity:98%Color and Shape:SolidMolecular weight:544.68Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formula:C26H52N6O11SPurity:94.68% - 99.80%Color and Shape:SolidMolecular weight:656.79Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formula:C16H18O9Purity:98.76% - 99.67%Color and Shape:SolidMolecular weight:354.31Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purity:100% - 99.89%Color and Shape:Bright Yellow-Orange Amorphous Solid Crystalline YellowMolecular weight:493.94Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formula:C16H8F5NO4SPurity:97.99%Color and Shape:SolidMolecular weight:405.3Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purity:99% - 99.82%Color and Shape:SolidMolecular weight:352.34Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Formula:C6H7K3O8Purity:95%Color and Shape:White Solid CrystallineMolecular weight:324.41THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormula:C11H12F3N3O3Purity:100%Color and Shape:SolidMolecular weight:291.23dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formula:C5H8N2O5Purity:≥95%Color and Shape:SolidMolecular weight:176.13Ref: TM-TL0001
1mg49.00€5mg97.00€10mg169.00€25mg349.00€50mg520.00€100mg748.00€200mg1,026.00€1mL*10mM (DMSO)106.00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formula:C28H35NO3Purity:99.22%Color and Shape:SolidMolecular weight:433.58Ref: TM-T13289
1mg107.00€5mg227.00€10mg378.00€25mg620.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)250.00€IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purity:99.97%Color and Shape:SolidMolecular weight:328.33LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formula:C26H29NO5Purity:98.1% - 99.10%Color and Shape:SolidMolecular weight:435.51Ref: TM-T3494
2mg47.00€5mg69.00€10mg89.00€25mg183.00€50mg298.00€100mg449.00€500mg938.00€1mL*10mM (DMSO)69.00€1,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFormula:C13H8N2O3Purity:97.75%Color and Shape:SolidMolecular weight:240.21Ref: TM-T21653
5mg51.00€10mg84.00€25mg153.00€50mg235.00€100mg376.00€200mg553.00€500mg883.00€1mL*10mM (DMSO)57.00€Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Formula:C8H9ClN4Purity:99.1% - 99.86%Color and Shape:Yellow Crystals White Crystalline SolidMolecular weight:196.64
