Carbonic Anhydrase
Carbonic anhydrase is an enzyme that catalyzes the reversible conversion of carbon dioxide and water into bicarbonate and protons. This enzyme plays a crucial role in maintaining acid-base balance, respiration, and the transport of carbon dioxide in the blood. Inhibitors of carbonic anhydrase are used in the treatment of glaucoma, epilepsy, and altitude sickness, as well as in research on acid-base homeostasis and gas exchange. At CymitQuimica, we offer a range of high-quality carbonic anhydrase inhibitors and reagents to support your research in enzymology, respiratory physiology, and therapeutic development.
Products of "Carbonic Anhydrase"
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Carbonic anhydrase inhibitor 15
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].Formula:C27H33N5O2S2Purity:98%Color and Shape:SolidMolecular weight:523.71SH7s
SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.Formula:C24H19ClF3N5O4SColor and Shape:SolidMolecular weight:565.95Polmacoxib
CAS:Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Formula:C18H16FNO4SPurity:97.88%Color and Shape:SolidMolecular weight:361.39Ref: TM-T21294
2mg47.00€5mg70.00€10mg107.00€25mg173.00€50mg259.00€100mg378.00€200mg563.00€1mL*10mM (DMSO)77.00€ALP/Carbonic anhydrase-IN-1
CAS:Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkalineFormula:C15H16N2Purity:98%Color and Shape:SolidMolecular weight:224.3CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Formula:C23H21N5O3SColor and Shape:SolidMolecular weight:447.51CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Color and Shape:Odour SolidWES-1
CAS:WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines,Formula:C20H20N4O3SPurity:98%Color and Shape:SolidMolecular weight:396.46Zonisamide
CAS:Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Formula:C8H8N2O3SPurity:99.05% - 99.9%Color and Shape:Off-White PowderMolecular weight:212.23hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Formula:C22H20N4O6S2Molecular weight:500.547Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formula:C7H6ClN3O4S2Purity:95.42%Color and Shape:Crystals Physical Description Crystals; White Powder (Ntp 1992)Molecular weight:295.72hCAII-IN-9
CAS:hCAII-IN-9 inhibits hCA II/IX/XII with IC50s of 1.18, 0.17, 2.99 μM; not BBB permeable.Formula:C15H16ClN3O5S2Purity:98.63%Color and Shape:SolidMolecular weight:417.89Carbonic anhydrase inhibitor 12
CAS:CA Inhibitor 12 strongly blocks CA II (K_i 1.72 nM), also inhibits CA I (271 nM), shows anticancer effects.Formula:C27H22BrN5O5S2Purity:98%Color and Shape:SolidMolecular weight:640.53CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Formula:C18H19NO6SColor and Shape:SolidMolecular weight:377.41U-104
CAS:U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).Formula:C13H12FN3O3SPurity:100% - 99.6%Color and Shape:SolidMolecular weight:309.32Ref: TM-T2017
5mg35.00€10mg52.00€25mg87.00€50mg142.00€100mg250.00€200mg399.00€500mg652.00€1mL*10mM (DMSO)58.00€Dichlorphenamide
CAS:Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.Formula:C6H6Cl2N2O4S2Purity:96.87% - 98.51%Color and Shape:Needles From Dimethylsulfoxide + Water SolidMolecular weight:305.16Ref: TM-T6469
5mg50.00€10mg65.00€25mg87.00€50mg96.00€100mg140.00€200mg202.00€500mg340.00€1mL*10mM (DMSO)59.00€CAIX Inhibitor S4
CAS:CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Formula:C15H17N3O4SPurity:98.35%Color and Shape:SolidMolecular weight:335.38Ref: TM-T36758
2mg40.00€5mg60.00€10mg96.00€25mg188.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)66.00€EMAC10101d
CAS:compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with anFormula:C17H15Cl2N3O2S2Purity:99.96%Color and Shape:SolidMolecular weight:428.36hCAI/II/IV-IN-28
CAS:hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.Formula:C14H15N3O3SPurity:96.48%Color and Shape:SolidMolecular weight:305.35Carbonic anhydrase inhibitor 26
Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.Formula:C17H14N6O4Color and Shape:SolidMolecular weight:366.33Perfluorohexane sulfonamide
CAS:Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.Formula:C6H2F13NO2SColor and Shape:SolidMolecular weight:399.13Tioxolone
CAS:Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.Formula:C7H4O3SPurity:97.79%Color and Shape:Light Yellow To Beige PowderMolecular weight:168.172,3-dihydro-1H-indene-5-sulfonamide
CAS:2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.Formula:C9H11NO2SPurity:99.89%Color and Shape:SolidMolecular weight:197.25Ref: TM-T8611
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)149.00€hCAIX-IN-16
CAS:hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII.Formula:C20H20N8O2SPurity:98%Color and Shape:SolidMolecular weight:436.49hCAIX/XII-IN-14
hCAIX/XII-IN-14 (Compound 1i) is an inhibitor of hCAIX and hCAXII, with Ki values of 9.4 nM for hCAII, 5.6 nM for hCAIX, and 6.3 nM for hCAXII.Formula:C16H14F3N3O4SColor and Shape:SolidMolecular weight:401.36Disulfamide
CAS:Disulfamide: Oral carbonic anhydrase inhibitor, IC50 0.07 μM, diuretic by blocking Na+/HCO3- reabsorption.Formula:C7H9ClN2O4S2Purity:98.1%Color and Shape:SolidMolecular weight:284.74hCA/VEGFR-2-IN-1
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (Formula:C21H17FN6O3SPurity:98%Color and Shape:SolidMolecular weight:452.46Methyclothiazide
CAS:Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions includingFormula:C9H11Cl2N3O4S2Purity:99.13%Color and Shape:SolidMolecular weight:360.24hCAIX/VII-IN-1
hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX.Formula:C16H13BFN3O3Purity:98%Color and Shape:SolidMolecular weight:325.1Brinzolamide
CAS:Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.Formula:C12H21N3O5S3Purity:100% - 99.84%Color and Shape:Crystalline SolidMolecular weight:383.51AChE/CA I-IN-1
AChE/CA I-IN-1 (Compound 2g) acts as an inhibitor for both AChE and hCA I, with Ki values of 1.85 µM and 0.53 µM, respectively. It has shown potential applications in the research of Alzheimer's disease, glaucoma, and epilepsy.Formula:C14H19NO6SColor and Shape:SolidMolecular weight:329.37Methazolamide
CAS:Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.Formula:C5H8N4O3S2Purity:98.45% - 99.77%Color and Shape:Crystals From Water SolidMolecular weight:236.27Carbonic anhydrase
CAS:Carbonic anhydrase, a zinc enzyme in all life forms, converts CO2 to bicarbonate; studied for cancer, glaucoma, obesity, epilepsy.Color and Shape:SolidIndisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Formula:C14H12ClN3O4S2Purity:98.68% - 99.77%Color and Shape:SolidMolecular weight:385.85Ref: TM-T4321
1mg35.00€2mg46.00€5mg66.00€10mg93.00€25mg137.00€50mg210.00€100mg314.00€1mL*10mM (DMSO)72.00€AV22-149
AV22-149 (compound 22) is an inhibitor of Carbonic Anhydrase .Formula:C23H28F3N3O6S2Color and Shape:SolidMolecular weight:563.61Dorzolamide hydrochloride
CAS:Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme thatFormula:C10H17ClN2O4S3Purity:99.48% - 99.67%Color and Shape:White Off-White Crystalline PowderMolecular weight:360.9hCAXII-IN-7
hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability.Formula:C26H25N5O6S2Purity:98%Color and Shape:SolidMolecular weight:567.64Topiramate
CAS:Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.Formula:C12H21NO8SPurity:99.79% - 99.92%Color and Shape:White To Off-White Crystalline PowderMolecular weight:339.36Orthanilamide
CAS:Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.Formula:C6H8N2O2SPurity:99.27% - 99.96%Color and Shape:White To Pale Cream Crystalline Powder Or CrystalsMolecular weight:172.2Acetazolamide sodium
CAS:Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.Formula:C4H5N4NaO3S2Purity:100%Color and Shape:SolidMolecular weight:244.23hBChE-IN-3
hBChE-IN-3 (compound 30) serves as both an activator of carbonic anhydrase (CA) and an inhibitor of cholinesterase (ChE), exhibiting IC50 values of 7.4 nM for AchE and 1.9 nM for BchE. This compound is utilized in the research of neurodegenerative and psychiatric disorders.Color and Shape:Odour SolidCompound CDy9
CAS:Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.Formula:C15H16N2O5SPurity:99.75%Color and Shape:SoildMolecular weight:336.36Ref: TM-T67774
2mg38.00€5mg58.00€10mg96.00€25mg170.00€50mg253.00€100mg364.00€200mg512.00€1mL*10mM (DMSO)71.00€Benzolamide
CAS:Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.Formula:C8H8N4O4S3Purity:97.03%Color and Shape:SolidMolecular weight:320.37Ref: TM-T23782
5mg51.00€10mg88.00€25mg160.00€50mg235.00€100mg349.00€200mg515.00€1mL*10mM (DMSO)57.00€α-Glycosidase-IN-2
α-Glycosidase-IN-2 (compound 8b) is an inhibitor of α-glycosidase, displaying Ki values of 74.16 nM and 6.09 nM for aldose reductase and α-glycosidase, respectively. This compound is utilized in research related to diabetes.Formula:C25H22N6OS2Color and Shape:SolidMolecular weight:486.614-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
CAS:4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide (4-Amino-6-(trifluoromethyl)benzene-1,3-d) is a carbonic anhydrase inhibitor, used as a potential anti-Formula:C7H8F3N3O4S2Purity:98.58%Color and Shape:SolidMolecular weight:319.28Sultiame
CAS:Sultiame is an inhibitor of carbonic anhydrase. Sultiame can be used in antiepileptic research.Formula:C10H14N2O4S2Purity:99.86%Color and Shape:SolidMolecular weight:290.36Cyclamic acid sodium
CAS:Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.Formula:C6H12NNaO3SPurity:99.84%Color and Shape:SolidMolecular weight:201.22hCAI/II-IN-6
CAS:hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA).Formula:C19H24N4O3SPurity:97.07%Color and Shape:SolidMolecular weight:388.48hCAIX-IN-15
CAS:hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancerFormula:C18H14FN7O2SPurity:98%Color and Shape:SolidMolecular weight:411.41hCAIX/XII-IN-8
CAS:hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.Formula:C16H13Cl2N5O3SPurity:98%Color and Shape:SolidMolecular weight:426.28Benzthiazide
CAS:Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.Formula:C15H14ClN3O4S3Purity:100% - 99.79%Color and Shape:Crystals From Acetone SolidMolecular weight:431.94
