ROR
Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.
Products of "ROR"
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Found 37 products on this category.
RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Formula:C23H17Cl2F3N2O4Purity:99%Color and Shape:SolidMolecular weight:513.29Ref: TM-T9623
1mg52.00€5mg116.00€10mg178.00€25mg311.00€50mg444.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)131.00€GSK805
CAS:GSK805 is a potent, orally bioavailable and CNS-penetrant RORγt inhibitor.Cost-effective and quality-assured.Formula:C23H18Cl2F3NO4SPurity:98% - ≥95%Color and Shape:SolidMolecular weight:532.36Ref: TM-T7388
1mg56.00€2mg79.00€5mg120.00€10mg187.00€25mg378.00€50mg462.00€100mg662.00€200mg948.00€1mL*10mM (DMSO)143.00€RORγt Inverse agonist 6
CAS:RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.Formula:C28H29ClN6O5Purity:98.65%Color and Shape:SolidMolecular weight:565.02Ref: TM-T12753
1mg62.00€5mg140.00€10mg202.00€25mg324.00€50mg437.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)168.00€XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Formula:C23H15F7N2O4Purity:99.96%Color and Shape:SolidMolecular weight:516.37SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Formula:C17H10F9NO2Purity:98.74%Color and Shape:SolidMolecular weight:431.25Ref: TM-T4594
1mg42.00€2mg55.00€5mg89.00€10mg115.00€25mg226.00€50mg368.00€100mg547.00€1mL*10mM (DMSO)92.00€ML 209
CAS:ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcriptionFormula:C25H31NO6Purity:99.65%Color and Shape:SolidMolecular weight:441.52TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Formula:C29H30N2O3Purity:98%Color and Shape:SolidMolecular weight:454.56TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Formula:C31H30N2O4Purity:98.02%Color and Shape:SolidMolecular weight:494.58Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Formula:C21H22O8Purity:98.78% - 99.76%Color and Shape:SolidMolecular weight:402.39Ref: TM-T2834
5mg57.00€10mg88.00€25mg124.00€50mg168.00€100mg265.00€200mg393.00€500mg653.00€1mL*10mM (DMSO)59.00€Methyl-3β-hydroxycholenate
CAS:Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.Formula:C25H40O3Purity:98.78%Color and Shape:SolidMolecular weight:388.58SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Formula:C15H13F6N3O4S2Purity:98.93%Color and Shape:SolidMolecular weight:477.4TMP780
CAS:TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Formula:C31H30N2O4Purity:98%Color and Shape:SolidMolecular weight:494.58Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Formula:C26H28N8O3SPurity:98.78%Color and Shape:SolidMolecular weight:532.62TAK-828F
CAS:TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.Formula:C28H32FN3O5Purity:98%Color and Shape:SolidMolecular weight:509.57RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Formula:C35H60N2O2Purity:98%Color and Shape:SolidMolecular weight:540.86ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Formula:C23H30BrN7Color and Shape:SolidMolecular weight:484.44MRL-871
CAS:MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Formula:C22H12ClF3N2O3Purity:99.66%Color and Shape:SolidMolecular weight:444.79Ref: TM-T62622
1mg97.00€5mg235.00€10mg395.00€25mg793.00€50mg1,216.00€100mg1,890.00€200mg2,547.00€1mL*10mM (DMSO)263.00€3-Oxo-5β-cholanoic acid
CAS:3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFormula:C24H38O3Purity:98.01% - 99.86%Color and Shape:SolidMolecular weight:374.56Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Formula:C24H20Cl3F3N2O3Purity:99.57%Color and Shape:SolidMolecular weight:547.78Ref: TM-T9635
1mg87.00€5mg170.00€10mg274.00€25mg497.00€50mg742.00€100mg1,103.00€1mL*10mM (DMSO)207.00€Vimirogant
CAS:Vimirogant is a RORγ inhibitor (Ki: <100 nM).Formula:C27H35F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:552.65SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Formula:C13H9F6NO3S2Purity:99.77%Color and Shape:SolidMolecular weight:405.34T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formula:C17H12F9NO3SPurity:98% - 99.58%Color and Shape:SolidMolecular weight:481.33Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Formula:C27H40O4Purity:99.5% - 99.92%Color and Shape:SolidMolecular weight:428.6Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Formula:C27H23F6NO6SPurity:99.92%Color and Shape:SolidMolecular weight:603.53Ref: TM-TQ0007
1mg85.00€5mg147.00€10mg197.00€25mg329.00€50mg490.00€100mg710.00€1mL*10mM (DMSO)187.00€RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Formula:C27H37NO5SMolecular weight:487.651SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Formula:C26H24F7N3OPurity:98.2%Color and Shape:SolidMolecular weight:527.48Ref: TM-T16929
1mg52.00€5mg96.00€10mg180.00€25mg274.00€50mg376.00€100mg533.00€500mg1,130.00€1mL*10mM (DMSO)120.00€RORγt inhibitor 4
CAS:RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.Formula:C22H16Cl2F3NO4SColor and Shape:SolidMolecular weight:518.333RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Formula:C24H28F3NO5SColor and Shape:SolidMolecular weight:499.54XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Formula:C25H20F7NO4SPurity:98.81%Color and Shape:SolidMolecular weight:563.48Ref: TM-T13362
1mg87.00€5mg170.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€500mg1,691.00€1mL*10mM (DMSO)205.00€RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Formula:C26H33N7O2Purity:98%Color and Shape:SolidMolecular weight:475.59S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Formula:C26H25F3N2O4SPurity:99.24% - 99.31%Color and Shape:SolidMolecular weight:518.55Ref: TM-T16832
1mg57.00€5mg125.00€10mg188.00€25mg335.00€50mg470.00€100mg662.00€500mg1,320.00€1mL*10mM (DMSO)142.00€AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Formula:C21H18F6N2O5SPurity:99.75%Color and Shape:SolidMolecular weight:524.43Ref: TM-T14369
1mg58.00€5mg135.00€10mg197.00€25mg306.00€50mg444.00€100mg562.00€1mL*10mM (DMSO)158.00€RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Formula:C26H26F8N2O6S2Purity:98%Color and Shape:SolidMolecular weight:678.61A-9758
CAS:A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Formula:C25H23Cl2F3N2O3Purity:98%Color and Shape:SolidMolecular weight:527.36RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Formula:C23H15Cl2F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:555.36SR0987
CAS:SR0987 is a RORγt agonist,Formula:C16H10ClF6NO2Purity:99.43%Color and Shape:SolidMolecular weight:397.7Ref: TM-T4670
2mg42.00€5mg59.00€10mg92.00€25mg188.00€50mg329.00€100mg490.00€200mg697.00€1mL*10mM (DMSO)66.00€FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Formula:C22H15ClF3N3O3Purity:98%Color and Shape:SolidMolecular weight:461.82
