Lipoxygenase

BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.

Applications p-Hexylresorcinol shows antiimnflammatory activity acting on the human 5-LO (5-Lipoxygenase) proinflammatory enzyme Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Filosa, R. et al.: Eur. j. Med. Chem., 67, 269 (2013);

LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX).

CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.

Applications 2,4-Dichlorobenzoyl Chloride is a reactant used in the synthesis of aroyl(sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mahdavi, M., et. al.: Eur. J. Med. Chem., 82, 308 (2014)

2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.

1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.

Applications Nordihydro Guaiaretic Acid is a lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, whereas Resveratrol itself had no activity and its oxidation efficiency was low. References Brash, A., et al.: J. Biol. Chem., 274, 23679 (1999), Fujimoto, A., et al.: Bioorg. Med. Chem. Lett., 20, 7393 (2010), Ridolfi, M., et al.: J. Agric. Food Chem., 50, 835 (2002),

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1. References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).

RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.

Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic

Applications Dimethyl (2-Oxoheptyl)phosphonate is a useful synthetic intermediate, and is used as a reagent to synthesize Caffeic acid (C080000) derivatives, which function as 5-lipoxygenase, 12-lipoxygenase, and prostaglandin synthase inhibitors. References Sugiura, M., et al.: Chem. Pharm. Bull., 37, 1039 (1989)

E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.

U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.

COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.

Oleoyl coenzyme A lithium (Oleoyl-CoA lithium) is a thioester of oleic acid and coenzyme A, acting as an allosteric inhibitor of h15-LOX-2.

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors