Phospholipase
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic substances, playing a critical role in membrane biology and the generation of signaling molecules. Inhibitors of phospholipases are used to study their role in inflammatory diseases, cardiovascular disorders, and neurodegeneration. These inhibitors are also valuable in exploring lipid signaling pathways and their implications in disease mechanisms. At CymitQuimica, we provide a variety of phospholipase inhibitors to support your research in inflammation, lipid metabolism, and cell signaling.
Products of "Phospholipase"
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hnps-PLA Inhibitor
CAS:Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).Formula:C21H21N3O4Purity:98.95%Color and Shape:SolidMolecular weight:379.41Ref: TM-T4192
1mg56.00€2mg81.00€5mg119.00€10mg202.00€25mg341.00€50mg509.00€100mg725.00€1mL*10mM (DMSO)137.00€RHC 80267
CAS:RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)Formula:C20H34N4O4Purity:99.54%Color and Shape:White SolidMolecular weight:394.51Compound 48/80 trihydrochloride
CAS:Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。Formula:C32H48Cl3N3O3Purity:98%Color and Shape:SolidMolecular weight:629.1Rilapladib
CAS:Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activatingFormula:C40H38F5N3O3SPurity:97.29%Color and Shape:SolidMolecular weight:735.8Ref: TM-T16751
1mg93.00€5mg227.00€10mg369.00€25mg622.00€50mg885.00€100mg1,206.00€1mL*10mM (DMSO)369.00€CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53Melittin
CAS:Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.Formula:C131H229N39O31Purity:98.37% - 99.14%Color and Shape:SolidMolecular weight:2846.46RPI-1
CAS:RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.Formula:C17H15NO4Purity:98.28% - ≥95%Color and Shape:SolidMolecular weight:297.31DPTIP
CAS:DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.Formula:C21H18N2O3SPurity:98.80%Color and Shape:SolidMolecular weight:378.44Ref: TM-T60043
1mg48.00€2mg63.00€5mg96.00€10mg153.00€25mg298.00€50mg487.00€100mg710.00€1mL*10mM (DMSO)96.00€5-HT1A modulator 1
CAS:5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).Formula:C21H25N3O2SPurity:99.66%Color and Shape:SolidMolecular weight:383.51(E/Z)-Polydatin
CAS:(E/Z)-Polydatin, a resveratrol glycoside from Picea/Polygonum, in grapes & chocolate, has anti-inflammatory and anti-cancer properties.Formula:C20H22O8Purity:98.78% - 99.16%Color and Shape:SolidMolecular weight:390.38Darapladib
CAS:Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.Formula:C36H38F4N4O2SPurity:100% - 99.82%Color and Shape:SolidMolecular weight:666.77Ref: TM-T6109
1mg52.00€2mg70.00€5mg96.00€10mg169.00€25mg329.00€50mg535.00€100mg747.00€500mg1,510.00€1mL*10mM (DMSO)154.00€ASM-IN-3
CAS:ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.Formula:C17H13ClN2O4Color and Shape:SolidMolecular weight:344.75Desketoraloxifene
CAS:Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).Formula:C27H27NO3SPurity:98%Color and Shape:SolidMolecular weight:445.57Bromoenol lactone
CAS:NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.Formula:C16H13BrO2Color and Shape:SolidMolecular weight:317.18Tanshinone I
CAS:Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.Formula:C18H12O3Purity:98.31% - 98.70%Color and Shape:SolidMolecular weight:276.291-Naphthaleneacetic acid potassium salt
CAS:1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.Formula:C12H9O2·KPurity:97.68%Color and Shape:Off-White To Beige PowderMolecular weight:224.3ML-095 hydrochloride
CAS:ML-095 hydrochloride (CID-25067483 hydrochloride) is a specific placental alkaline phosphatase inhibitor.Formula:C13H15ClN2O3Purity:98.18%Color and Shape:SolidMolecular weight:282.72Ref: TM-T21969
2mg38.00€5mg58.00€10mg96.00€25mg170.00€50mg298.00€100mg432.00€200mg607.00€1mL*10mM (DMSO)64.00€Halobetasol propionate
CAS:Halobetasol propionate (BMY-30056) is the salt of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities.Formula:C25H31ClF2O5Purity:99.89%Color and Shape:Distributed As 0 05% OintmentMolecular weight:484.96AA26-9
CAS:AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.Formula:C7H10N4OPurity:99.88%Color and Shape:SolidMolecular weight:166.18Ref: TM-T3990
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg210.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)87.00€VU533
CAS:VU533 is a NAPE-PLD activator, EC50=0.30 µM, boosts macrophage activity, potential in cardiometabolic diseases.Formula:C21H22FN3O3S2Purity:99.08%Color and Shape:SolidMolecular weight:447.55trans-Benzylideneacetone
CAS:trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.Formula:C10H10OPurity:97.48%Color and Shape:Light Yellow Low Melting Crystalline MassMolecular weight:146.19Aristolochic acid C
CAS:Aristolochic acid C is a derivative of Aristolochic acid which is a phospholipase A2 inhibitor.Formula:C16H9NO7Purity:98.14%Color and Shape:White PowderMolecular weight:327.25Carbazochrome
CAS:Carbazochrome (Adchnon) is an antihemorrhagic that promotes platelet aggregation to stop bleeding, possibly for surgeries and hemorrhoids treatment.Formula:C10H12N4O3Purity:98.36%Color and Shape:Nacarat Crystalline PowderMolecular weight:236.23Fuzapladib
CAS:Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.Formula:C15H20F3N3O3SPurity:99.65%Color and Shape:SoildMolecular weight:379.4Tris(2,4-di-tert-butylphenyl)phosphate
CAS:Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) inhibits secretory phospholipase A2 (sPLA2) with anti-inflammatory effect. Cost-effective and quality-assured.Formula:C42H63O4PPurity:99.73%Color and Shape:SolidMolecular weight:662.92ML299
CAS:ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).Formula:C23H26BrFN4O2Purity:98%Color and Shape:SolidMolecular weight:489.38ML-211
CAS:ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)Formula:C25H30N4O2Purity:97.07%Color and Shape:SolidMolecular weight:418.53BAPTA
CAS:BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.Formula:C22H24N2O10Purity:96.28% - ≥95%Color and Shape:White SolidMolecular weight:476.43LCL521
CAS:LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.Formula:C31H52N4O7Purity:98%Color and Shape:SolidMolecular weight:592.77ML348
CAS:ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).Formula:C18H17ClF3N3O3Purity:99% - 99.88%Color and Shape:SolidMolecular weight:415.79Ref: TM-T3439
2mg47.00€5mg69.00€10mg97.00€25mg227.00€50mg354.00€100mg567.00€200mg792.00€500mg1,198.00€AACOCF3
CAS:AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid.Formula:C21H31F3OPurity:99% - 99%Color and Shape:Yellow LiquidMolecular weight:356.473-Nitrocoumarin
CAS:3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.Formula:C9H5NO4Purity:97.28%Color and Shape:SolidMolecular weight:191.14U-73343
CAS:U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.Formula:C29H42N2O3Purity:99.06%Color and Shape:SolidMolecular weight:466.66GK187
CAS:GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.Formula:C14H15F5O2Color and Shape:SolidMolecular weight:310.26Ref: TM-T37221
1mg87.00€5mg183.00€10mg296.00€25mg565.00€50mg909.00€100mg1,444.00€200mg1,882.00€1mL*10mM (DMSO)202.00€Lp-PLA2-IN-16
CAS:Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].Formula:C22H17F5N4O3Purity:98%Color and Shape:SolidMolecular weight:480.39Columbin
CAS:Columbin: anti-inflammatory, prevents colon cancer, inhibits PLA2 in RBC dose-dependently.Formula:C20H22O6Purity:99.34% - 99.74%Color and Shape:SolidMolecular weight:358.39Lp-PLA2-IN-12
CAS:Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-Formula:C24H23F2N5O3Purity:98%Color and Shape:SolidMolecular weight:467.47Rhamnetin
CAS:Rhamnetin (beta-Rhamnocitrin), a quercetin derivative found in Coriandrum sativum, has antioxidant and anti-inflammatory activities.Formula:C16H12O7Purity:97.6%Color and Shape:SolidMolecular weight:316.26Omeprazole
CAS:Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor.Formula:C17H19N3O3SPurity:98.43% - 98.48%Color and Shape:White SolidMolecular weight:345.42LEI110
CAS:LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.Formula:C25H23F3N2O3Purity:97.56% - 98.8%Color and Shape:SolidMolecular weight:456.46Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.47% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€A4333
A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.Purity:98%Color and Shape:Odour SolidSB-435495
CAS:SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.Formula:C38H40F4N6O2SPurity:≥98%Color and Shape:SolidMolecular weight:720.82Difluprednate
CAS:Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.Formula:C27H34F2O7Purity:99.23% - 99.86%Color and Shape:SolidMolecular weight:508.55Ref: TM-T6472
10mg39.00€25mg55.00€50mg80.00€100mg101.00€200mg177.00€500mg283.00€1mL*10mM (DMSO)48.00€Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Formula:C16H14F3N3O3Purity:98%Color and Shape:SolidMolecular weight:353.3ML349
CAS:ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).Formula:C23H22N2O4S2Purity:99.59% - 99.82%Color and Shape:SolidMolecular weight:454.56FAAH/cPLA2α-IN-1
CAS:FAAH/cPLA2α-IN-1 is a compound that simultaneously inhibits both FAAH and cPLA2α, demonstrating potent activity with half-maximal inhibitory concentrations (Formula:C19H26N4O5Purity:98%Color and Shape:SolidMolecular weight:390.43ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Formula:C16H12BrN3O4Purity:98%Color and Shape:SolidMolecular weight:390.19A3373
CAS:A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) ofFormula:C17H9F7N2OPurity:98%Color and Shape:SoildMolecular weight:390.26CAY10650
CAS:CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).Formula:C28H25NO6Purity:95.56%Color and Shape:SolidMolecular weight:471.5Ref: TM-TQ0105
1mg51.00€5mg137.00€10mg210.00€25mg424.00€50mg628.00€100mg938.00€1mL*10mM (DMSO)140.00€
