5-HT Receptor
5-HT receptors, also known as serotonin receptors, are a group of G protein-coupled receptors (GPCRs) that mediate the effects of serotonin, a neurotransmitter involved in mood regulation, anxiety, sleep, appetite, and other physiological processes. These receptors are divided into several subtypes, each with distinct functions and pharmacological properties. 5-HT receptor modulators are widely studied for their roles in treating depression, anxiety disorders, and other neuropsychiatric conditions. At CymitQuimica, we offer a range of high-quality 5-HT receptor modulators to support your research in neuropharmacology, mood disorders, and GPCR signaling.
Products of "5-HT Receptor"
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Arotinolol
CAS:Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Formula:C15H21N3O2S3Color and Shape:White SolidMolecular weight:371.54Wf-516
CAS:Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormula:C25H25Cl2N3O4Purity:98%Color and Shape:SolidMolecular weight:502.395-HT2C agonist-3
CAS:5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-inducedFormula:C19H23ClFNO2Purity:98%Color and Shape:SolidMolecular weight:351.84Puerarin
CAS:Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.Formula:C21H20O9Purity:98.90% - 99.21%Color and Shape:Yellow Brown Fine PowderMolecular weight:416.38Cilansetron
CAS:Cilansetron is an effective and selective 5-HT3 receptor antagonist that can be used for related diseases caused by colitis.Formula:C20H21N3OPurity:99.77% - 99.85%Color and Shape:SolidMolecular weight:319.4Clothiapine
CAS:Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class.Formula:C18H18ClN3SPurity:99.93%Color and Shape:SolidMolecular weight:343.87GSK163090
CAS:GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).Formula:C25H29N5OPurity:99.20%Color and Shape:SolidMolecular weight:415.53Ref: TM-TQ0311
1mg37.00€2mg52.00€5mg80.00€10mg125.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)87.00€JPC0323
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequateFormula:C22H43NO4Purity:98%Color and Shape:SolidMolecular weight:385.585-HT2C agonist-4
CAS:Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.Formula:C24H25N5OColor and Shape:SolidMolecular weight:399.49Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purity:99.73%Color and Shape:Crystalline SolidMolecular weight:410.48MRS7925
MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosisFormula:C20H26IN5O3Purity:98%Color and Shape:SolidMolecular weight:511.36Escin IB
CAS:Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, toFormula:C55H86O24Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:1131.26Indophagolin
CAS:Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.Formula:C19H15BrClF3N2O3SPurity:99.76%Color and Shape:SolidMolecular weight:523.75Ref: TM-T8946
1mg58.00€5mg111.00€10mg170.00€25mg284.00€50mg393.00€100mg552.00€200mg748.00€1mL*10mM (DMSO)129.00€Pipamperone
CAS:Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.Formula:C21H30FN3O2Purity:99.94%Color and Shape:White PowderMolecular weight:375.48Ref: TM-T12480
1mg62.00€2mg85.00€5mg119.00€10mg170.00€25mg283.00€50mg430.00€100mg622.00€1mL*10mM (DMSO)131.00€WAY208466 dihydrochloride
CAS:WAY208466 dihydrochloride is a 5-HT6 receptor agonist (EC50=7.3 nM) with antidepressant and anxiolytic activity.Formula:C17H20Cl2FN3O2SPurity:98.43%Color and Shape:SolidMolecular weight:420.33WAY-100635 maleate
CAS:WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).Formula:C25H34N4O2·xC4H4O4Purity:100%Color and Shape:White SolidMolecular weight:538.645Ref: TM-T3453
2mg46.00€5mg66.00€10mg95.00€25mg159.00€50mg226.00€100mg334.00€500mg807.00€1mL*10mM (DMSO)79.00€5-HT2A receptor agonist-6
CAS:5-HT2A receptor agonist-6 (compound 47) is a selective agonist of the 5-HT2A receptor with a pEC50 value of 6.58.Formula:C18H19N3O3Color and Shape:SolidMolecular weight:325.36Niaprazine
CAS:Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.Formula:C20H25FN4OPurity:99.5%Color and Shape:SolidMolecular weight:356.44Ref: TM-T36949
2mg40.00€5mg58.00€10mg96.00€25mg144.00€50mg210.00€100mg309.00€200mg444.00€1mL*10mM (DMSO)64.00€Brexpiprazole
CAS:Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.Formula:C25H27N3O2SPurity:99.06% - 99.96%Color and Shape:SolidMolecular weight:433.57SB 243213
CAS:SB 243213 is a 5-HT2C receptor antagonist with anxiolytic and antidepressant activity used in schizophrenia and movement disorders.Formula:C22H19F3N4O2Purity:100% - 100%Color and Shape:SolidMolecular weight:428.41Bemesetron
CAS:Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.Formula:C15H17Cl2NO2Purity:97.37%Color and Shape:SolidMolecular weight:314.21Prucalopride
CAS:Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.Formula:C18H26ClN3O3Purity:100%Color and Shape:SolidMolecular weight:367.87Ro4368554
CAS:Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Formula:C19H21N3O2SColor and Shape:SolidMolecular weight:355.454lumateperone Tosylate
CAS:lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist, a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors.Formula:C31H36FN3O4SPurity:95.83% - 98.57%Color and Shape:SolidMolecular weight:565.7F 14679
CAS:F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.Formula:C21H25ClF2N4OPurity:99.09%Color and Shape:SolidMolecular weight:422.9FFN246
CAS:FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation andFormula:C15H13FN2OPurity:98%Color and Shape:SolidMolecular weight:256.27SB 242084
CAS:SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.Formula:C21H19ClN4O2Purity:99.77% - ≥98%Color and Shape:SolidMolecular weight:394.85Ref: TM-T7277
1mg42.00€2mg55.00€5mg90.00€10mg115.00€25mg246.00€50mg472.00€100mg720.00€1mL*10mM (DMSO)89.00€Cisapride
CAS:Cisapride (R 51619), a 5-HT4 agonist, enhances gut peristalsis and gastric emptying, reduces reflux.Formula:C23H29ClFN3O4Purity:99.77%Color and Shape:White To Slightly Biege Powder SolidMolecular weight:465.95Ref: TM-T1291
5mg47.00€10mg59.00€25mg77.00€50mg99.00€100mg135.00€200mg235.00€500mg394.00€1mL*10mM (DMSO)55.00€(S)-Bexicaserin
CAS:(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].Formula:C15H19F2N3OPurity:98%Color and Shape:SolidMolecular weight:295.33Frovatriptan succinate hydrate
CAS:Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.Formula:C18H25N3O6Purity:99.95%Color and Shape:SolidMolecular weight:379.41Hypidone hydrochloride
CAS:Hypidone hydrochloride (YL0919) is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitorFormula:C18H23ClN2O2Purity:99.82% - 99.93%Color and Shape:SolidMolecular weight:334.84Aripiprazole
CAS:Aripiprazole (OPC-14597) is a piperazine/quinolone antipsychotic, partial agonist at 5-HT1A/D2, and antagonist at 5-HT2A.Formula:C23H27Cl2N3O2Purity:99.43% - 99.62%Color and Shape:Colourless Flake Crystalline SolidMolecular weight:448.39Naratriptan
CAS:Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.Formula:C17H25N3O2SPurity:99.08%Color and Shape:SolidMolecular weight:335.47Metoclopramide hydrochloride
CAS:Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.Formula:C14H22ClN3O2·HClPurity:99.99%Color and Shape:White To Off-White PowderMolecular weight:336.26Tiflucarbine
CAS:Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of solubleFormula:C16H17FN2SPurity:100%Color and Shape:SolidMolecular weight:288.38pCPA methyl ester hydrochloride
CAS:pCPA methyl ester HCl inhibits tryptophan hydroxylase, 5-HT synthesis, crosses blood-brain barrier, lowers central 5-HT.Formula:C10H13Cl2NO2Purity:99.08% - 99.88%Color and Shape:SolidMolecular weight:250.12Loxapine
CAS:Loxapine, a dibenzoxazepine antipsychotic, treats schizophrenia by blocking D2/D4 and serotonin receptors. Related to clozapine.Formula:C18H18ClN3OPurity:99.88%Color and Shape:Pale Yellowish Crystals From Petroleum Ether SolidMolecular weight:327.815-HT2 agonist-1
CAS:Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Formula:C19H23ClN2O2Purity:98%Color and Shape:SolidMolecular weight:346.85Gevotroline
CAS:Gevotroline, a chemical in palm wine that can be used to treat psychosis, is a 5-HT2 receptor antagonist that can be used to study behavioral disorders.Formula:C19H20FN3Purity:98.79%Color and Shape:SolidMolecular weight:309.385-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.Formula:C25H29ClN4O2SColor and Shape:SolidMolecular weight:485.04GTS-21 dihydrochloride
CAS:GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.Formula:C19H20N2O2·2HClPurity:100% - 99.62%Color and Shape:SolidMolecular weight:381.3Ref: TM-T2663
5mg51.00€10mg85.00€25mg115.00€50mg144.00€100mg216.00€200mg325.00€500mg545.00€1mL*10mM (DMSO)57.00€4-Iodoamphetamine hydrochloride
CAS:4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated phenethylamine characterized by the presence of an iodine atom at the para position of the phenyl group. It selectively induces serotonin release and inhibits reuptake in rat brain synaptosomes.Formula:C9H13ClINColor and Shape:SolidMolecular weight:297.56Citalopram hydrobromide
CAS:Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, therebyFormula:C20H22BrFN2OPurity:99.81%Color and Shape:White Crystalline PowderMolecular weight:405.304SB 204741
CAS:SB 204741 is a selective 5-HT2B antagonist with high affinity and pKi value of 7.1.Formula:C14H14N4OSPurity:99.83%Color and Shape:SolidMolecular weight:286.35Eletriptan hydrobromide
CAS:Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.Formula:C22H27BrN2O2SPurity:100% - 99.69%Color and Shape:Tan SolidMolecular weight:463.43Ref: TM-T0216
2mg39.00€5mg57.00€10mg70.00€25mg134.00€50mg230.00€100mg373.00€200mg555.00€1mL*10mM (DMSO)63.00€Cinitapride Hydrogen Tartrate
CAS:Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptorsFormula:C25H36N4O10Purity:98%Color and Shape:SolidMolecular weight:552.5812-Methyl-5-HT maleate
CAS:2-Methyl-5-HT maleate, a selective 5-HT3 agonist, shows anti-depressive effects.Formula:C15H18N2O5Purity:98%Color and Shape:SolidMolecular weight:306.31WAY-607695
CAS:WAY-607695 is a potential 5-HT1A receptor agonist.Formula:C13H12FNO2Purity:99.82%Color and Shape:SolidMolecular weight:233.24Rotigotine Hydrochloride
CAS:Rotigotine HCl, D3-preferential dopamine agonist, is 50x stronger than quinpirole in anti-Parkinson's efficacy.Formula:C19H26ClNOSPurity:99.53% - 99.56%Color and Shape:Almost White To White Crystalline PowderMolecular weight:351.93D3/5-HT receptor modulator-1
CAS:D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.Formula:C24H29N3O2Color and Shape:SolidMolecular weight:391.506
