5-HT Receptor
5-HT receptors, also known as serotonin receptors, are a group of G protein-coupled receptors (GPCRs) that mediate the effects of serotonin, a neurotransmitter involved in mood regulation, anxiety, sleep, appetite, and other physiological processes. These receptors are divided into several subtypes, each with distinct functions and pharmacological properties. 5-HT receptor modulators are widely studied for their roles in treating depression, anxiety disorders, and other neuropsychiatric conditions. At CymitQuimica, we offer a range of high-quality 5-HT receptor modulators to support your research in neuropharmacology, mood disorders, and GPCR signaling.
Products of "5-HT Receptor"
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Azasetron hydrochloride
CAS:Azasetron hydrochloride (Y-25130 HCl) is a 5-HT3 receptor antagonist which is used as an anti-emetic.Formula:C17H20ClN3O3·HClPurity:99.50%Color and Shape:SolidMolecular weight:386.27Trimipramine maleate
CAS:Trimipramine maleate, a tricyclic antidepressant, blocks serotonin and norepinephrine reuptake, boosting their levels and duration.Formula:C24H30N2O4Purity:99.47%Color and Shape:SolidMolecular weight:410.51Ritanserin
CAS:Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist.Cost-effective and quality-assured.Formula:C27H25F2N3OSPurity:99.45% - 99.89%Color and Shape:SolidMolecular weight:477.57Flumexadol
CAS:Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.Formula:C11H12F3NOPurity:98%Color and Shape:SolidMolecular weight:231.21DREADD agonist 21
CAS:DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).Formula:C17H18N4Purity:99.88%Color and Shape:SolidMolecular weight:278.35Ref: TM-T11095L
2mg34.00€5mg58.00€10mg85.00€25mg140.00€50mg221.00€100mg329.00€200mg472.00€1mL*10mM (DMSO)52.00€Mosapride Citrate
CAS:Mosapride Citrate (TAK-370 citrate), a gastroprokinetic agent, utilizes as a selective 5HT4 agonist.Formula:C21H25ClFN3O3·C6H8O7Purity:99.70%Color and Shape:White PowderMolecular weight:614.02Itasetron
CAS:Itasetron, a 5-HT3 antagonist, prevents memory loss in rats and has antiemetic effects in cancer treatments.Formula:C16H20N4O2Purity:100% - 99.63%Color and Shape:SolidMolecular weight:300.364-Chloro-L-phenylalanine
CAS:4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formula:C9H10ClNO2Purity:99.76% - 99.96%Color and Shape:SolidMolecular weight:199.63Isocorynoxeine
CAS:Isocorynoxeine reduces blood pressure, dilates vessels, and guards neurons against ischemia and glutamate toxicity.Formula:C22H26N2O4Purity:98% - 99.9%Color and Shape:SolidMolecular weight:382.45Donitriptan
CAS:Donitriptan 是一种 5-HT 受体激动剂,对 5-HT1B 和 5-HT1D 的 pKi 分别为 9.4 和 9.3。Formula:C23H25N5O2Purity:98.34%Color and Shape:SolidMolecular weight:403.485-MeO-pyr-T
CAS:5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) acts as a 5-HT1AR agonist, exhibiting Ki values of 0.577 μM and 373 μM for 5-HT1AR and 5-HT2AR, respectively. It inhibits the reuptake of 5-HT and triggers its release. Additionally, 5-MeO-pyr-T can induce reduced motor activity.Formula:C15H20N2OColor and Shape:SolidMolecular weight:244.33PRX-07034 hydrochloride
CAS:PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and decreases body weight in rodents.Formula:C21H29Cl2N3O4SPurity:98.50%Color and Shape:SolidMolecular weight:490.44Naftidrofuryl oxalate
CAS:Naftidrofuryl oxalate treats peripheral/cerebral vascular issues, boosts cell oxidation, is spasmolytic, and may block 5HT-2 serotonin receptors.Formula:C26H35NO7Purity:97.12% - 98.38%Color and Shape:SolidMolecular weight:473.567-Desmethyl-3-hydroxyagomelatine
CAS:7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.Formula:C14H15NO3Purity:98%Color and Shape:SolidMolecular weight:245.27Etoperidone
CAS:Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).Formula:C19H28ClN5OColor and Shape:SolidMolecular weight:377.91Org-12962
CAS:Org-12962: 5-HT2C agonist (pEC50: 7.01), anti-panic in rats, affects 5-HT2A/B (pEC50: 6.38/6.28).Formula:C10H11ClF3N3Purity:98.34%Color and Shape:SolidMolecular weight:265.66Perphenazine
CAS:Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.Formula:C21H26ClN3OSPurity:99.3% - 99.72%Color and Shape:SolidMolecular weight:403.97Eplivanserin
CAS:Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.Formula:C19H21FN2O2Purity:97.04%Color and Shape:SolidMolecular weight:328.38Zotepine
CAS:Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM,Formula:C18H18ClNOSPurity:99.78%Color and Shape:SolidMolecular weight:331.86Jatrorrhizine
CAS:Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species.Formula:C20H20NO4Purity:97.18% - 99.06%Color and Shape:SolidMolecular weight:338.38Pridefine
CAS:Pridefine: antidepressant, balances serotonin, dopamine, norepinephrine reuptake, weakly releases them.Formula:C19H21NPurity:99.05% - 99.23%Color and Shape:SolidMolecular weight:263.38YM348
CAS:YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Formula:C14H17N3OPurity:98%Color and Shape:SolidMolecular weight:243.38-OH-Dpat
CAS:8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Formula:C16H25NOPurity:98%Color and Shape:SolidMolecular weight:247.38Ethylpropyltryptamine
CAS:Ethylpropyltryptamine (EPT) is an orally active novel psychoactive substance. It is predicted to act as a partial agonist of the 5-HT2A receptor.Formula:C15H22N2Color and Shape:SolidMolecular weight:230.35Sarpogrelate hydrochloride
CAS:Sarpogrelate hydrochloride (MCI-9042), a 5-HT2 antagonist with high affinity (Ki=8.39nM), is used as an anti-platelet for PAD, improving vascular function.Formula:C24H32ClNO6Purity:99.73%Color and Shape:Colorless LiquidMolecular weight:465.97Dolasetron Mesylate
CAS:Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea followingFormula:C20H24N2O6SPurity:100%Color and Shape:White PowderMolecular weight:420.48Deramciclane
CAS:Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors.Formula:C20H31NOColor and Shape:SolidMolecular weight:301.47NPS ALX Compound 4a
CAS:NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)Formula:C25H25N3O2SPurity:98%Color and Shape:SolidMolecular weight:431.55AAZ-A 154 benzoate
CAS:AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.Formula:C21H26N2O3Color and Shape:SolidMolecular weight:354.44Nardosinonediol
CAS:Nardosinonediol is a natural compound derived from Nardostachys jatamansi that acts as a SERT inhibitor, regulating serotonin levels and antidepressant.Formula:C15H24O3Purity:98%Color and Shape:SolidMolecular weight:252.35Pimethixene
CAS:Pimethixene (Calmixen) blocks 5-HT1A, 2A/B/C, H1, D2/D4.4 & muscarinic M1/M2 receptors; potent with pKis 7.54-10.44.Formula:C19H19NSPurity:97.50%Color and Shape:SolidMolecular weight:293.43Ref: TM-T12489
2mg34.00€5mg50.00€10mg65.00€25mg106.00€50mg158.00€100mg226.00€200mg339.00€1mL*10mM (DMSO)52.00€SB-269970 hydrochloride
CAS:SB-269970 hydrochloride (SB-269970A) , a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivityFormula:C18H28N2O3S·HClPurity:98.45%Color and Shape:SolidMolecular weight:388.95Ogerin
CAS:Ogerin: GPR68 modulator, blocks mice fear recall, A2A inverse agonist/antagonist (Ki 220 nM), weak 5-HT2B antagonist (Ki 736 nM).Formula:C17H17N5OPurity:99.50% - 99.75%Color and Shape:SolidMolecular weight:307.35Ref: TM-T16378
1mg35.00€2mg52.00€5mg74.00€10mg115.00€25mg227.00€50mg380.00€100mg567.00€1mL*10mM (DMSO)86.00€Tandospirone citrate
CAS:Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)Formula:C27H37N5O9Purity:97.84% - 99.83%Color and Shape:SolidMolecular weight:575.61Quinupramine
CAS:Quinupramine: an oral antidepressant targeting the serotonin system; penetrates CNS; doesn’t affect β-adrenergic system.Formula:C21H24N2Purity:99.76%Color and Shape:SolidMolecular weight:304.43PF-03382792
CAS:PF-03382792 is a small molecule 5-HT4 receptor activator for the study of Alzheimer's disease.Formula:C23H32FN3O4Purity:98.09%Color and Shape:SolidMolecular weight:433.52NPS ALX Compound 4a hydrochloride(1:1)
NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.Formula:C25H26ClN3O2SPurity:99.8%Color and Shape:SoildMolecular weight:468.01Ref: TM-T12262L1
1mg52.00€5mg114.00€10mg172.00€25mg284.00€50mg411.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)138.00€Flesinoxan
CAS:Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).Formula:C22H26FN3O4Color and Shape:SolidMolecular weight:415.46Serazapine
CAS:Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders.Formula:C22H23N3O2Purity:98.06% - 99%Color and Shape:SolidMolecular weight:361.44VA012
CAS:VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formula:C21H19N3Color and Shape:SolidMolecular weight:313.40Dapoxetine hydrochloride
CAS:Dapoxetine hydrochloride (LY-210448 hydrochloride) is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.Formula:C21H23NO·HClPurity:99.5% - 99.70%Color and Shape:White To Off-White Crystalline SolidMolecular weight:341.87Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurity:97% - 99.94%Color and Shape:Crystals White To Off-White PowderMolecular weight:313.865-HT3-In-1
CAS:5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.Formula:C16H21ClN4O3Purity:98%Color and Shape:SolidMolecular weight:352.82Piclozotan
CAS:Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO)Formula:C23H24ClN3O2Purity:99%Color and Shape:SolidMolecular weight:409.91NPS ALX Compound 4a dihydrochloride
CAS:NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)Formula:C25H27Cl2N3O2SPurity:98%Color and Shape:SolidMolecular weight:504.47Facinicline hydrochloride
CAS:Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).Formula:C15H19ClN4OPurity:99.72%Color and Shape:SolidMolecular weight:306.79BIMU 8
CAS:BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.Formula:C19H27ClN4O2Purity:99.36%Color and Shape:SolidMolecular weight:378.9Ref: TM-T21946
1mg89.00€5mg172.00€10mg249.00€25mg416.00€50mg615.00€100mg873.00€500mg1,768.00€1mL*10mM (DMSO)185.00€Repinotan HCl
CAS:Repinotan HCl (Bay-x-3702) is a 5-HT1A receptor agonist with potent neuroprotective effects for the study of ischemic stroke and traumatic brain injury.Formula:C21H25ClN2O4SPurity:99.57%Color and Shape:SolidMolecular weight:436.95BF-1
CAS:BF-1 blocks 5-HT2B, may prevent migraines by hindering BW723C86/mCPP in guinea pigs.Formula:C22H25NO2SPurity:100% - 99.25%Color and Shape:SolidMolecular weight:367.50Vortioxetine hydrobromide
CAS:Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33Formula:C18H22N2S·HBrPurity:100% - 99.89%Color and Shape:SolidMolecular weight:379.36
