LRRK2
LRRK2 inhibitors are compounds that target and inhibit the activity of Leucine-Rich Repeat Kinase 2 (LRRK2), an enzyme involved in several cellular processes, including autophagy, vesicle trafficking, and inflammation. Mutations in the LRRK2 gene are associated with an increased risk of developing Parkinson's disease, making LRRK2 a significant target for neurodegenerative disease research. Inhibitors of LRRK2 are crucial for exploring its role in Parkinson's disease and for developing potential therapeutic strategies. At CymitQuimica, we offer a selection of LRRK2 inhibitors to support your research in neurodegeneration, kinase signaling, and therapeutic development.
Products of "LRRK2"
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LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurity:99.26%Color and Shape:SolidMolecular weight:414.5GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purity:97.93% - 99.94%Color and Shape:SolidMolecular weight:399.42IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurity:98.76% - 99.61%Color and Shape:SolidMolecular weight:483.63Ref: TM-T6176
1mg40.00€2mg52.00€5mg88.00€10mg139.00€25mg245.00€50mg406.00€100mg607.00€200mg845.00€1mL*10mM (DMSO)87.00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Color and Shape:Odour LiquidGNE-7915
CAS:GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.Formula:C19H21F4N5O3Purity:98% - ≥95%Color and Shape:SolidMolecular weight:443.4Ref: TM-T1945
5mg47.00€10mg62.00€25mg114.00€50mg187.00€100mg316.00€200mg410.00€500mg680.00€1mL*10mM (DMSO)50.00€GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Formula:C14H16F3N7Purity:98.01% - 99.96%Color and Shape:SolidMolecular weight:339.32Ref: TM-T6031
1mg47.00€2mg60.00€5mg119.00€10mg187.00€25mg376.00€50mg562.00€100mg802.00€500mg1,644.00€1mL*10mM (DMSO)96.00€LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Formula:C20H23N5O4Purity:99.73%Color and Shape:SolidMolecular weight:397.43Ref: TM-T11878
1mg74.00€2mg97.00€5mg160.00€10mg264.00€25mg557.00€50mg944.00€100mg1,491.00€1mL*10mM (DMSO)170.00€CZC-25146 hydrochloride
CAS:CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.Formula:C22H26ClFN6O4SPurity:98.76%Color and Shape:SolidMolecular weight:525PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Formula:C17H15N5OPurity:98.61% - 99.62%Color and Shape:SolidMolecular weight:305.33CZC-25146
CAS:CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).Formula:C22H25FN6O4SPurity:97.68%Color and Shape:SolidMolecular weight:488.54MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Formula:C21H25N5O2Purity:98.96%Color and Shape:SolidMolecular weight:379.46Ref: TM-T16115
1mg66.00€2mg96.00€5mg133.00€10mg197.00€25mg435.00€50mg658.00€100mg937.00€1mL*10mM (DMSO)142.00€CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Formula:C18H13ClF6N2O3Purity:99.80%Color and Shape:SolidMolecular weight:454.75EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formula:C22H22N8OPurity:98.06%Color and Shape:SolidMolecular weight:414.46Ref: TM-T39972
1mg70.00€2mg93.00€5mg156.00€10mg226.00€25mg409.00€50mg610.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)170.00€PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).Formula:C16H16N6OPurity:98.14% - 99.73%Color and Shape:SolidMolecular weight:308.34BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purity:97.44% - 99.61%Color and Shape:SolidMolecular weight:458.56CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formula:C22H26Cl2N6O4SPurity:98.21%Color and Shape:SolidMolecular weight:541.45Ref: TM-T39202
5mg52.00€10mg75.00€25mg135.00€50mg215.00€100mg319.00€200mg449.00€1mL*10mM (DMSO)64.00€HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purity:99.59%Color and Shape:SolidMolecular weight:377.83Ref: TM-T7196
2mg38.00€5mg58.00€10mg94.00€25mg170.00€50mg264.00€100mg380.00€200mg540.00€1mL*10mM (DMSO)65.00€CZC-54252
CAS:CZC-54252 is a potent inhibitor of LRRK2.Formula:C22H25ClN6O4SPurity:99.39%Color and Shape:SolidMolecular weight:504.99LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purity:98% - 98.82%Color and Shape:SolidMolecular weight:570.69PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Formula:C14H16N6OPurity:99.06%Color and Shape:SolidMolecular weight:284.32Ref: TM-T7729
2mg35.00€5mg50.00€10mg80.00€25mg135.00€50mg197.00€100mg306.00€200mg442.00€1mL*10mM (DMSO)55.00€
