Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Products of "Cyclooxygenase (COX) Inhibitors"
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Fenofibric acid
CAS:Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.Formula:C17H15ClO4Purity:99.36%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:318.75Harpagoside
CAS:Harpagoside: anti-inflammatory; 3 mM inhibits seed germination; reduces COX-2, iNOS mRNA, and protein in HepG2.Formula:C24H30O11Purity:100% - ≥95%Color and Shape:White To Off-White PowderMolecular weight:494.49Phenylbutazone
CAS:Phenylbutazone, an anti-inflammatory, reduces fever and pain, used for spondylitis and arthritis.Formula:C19H20N2O2Purity:99.70%Color and Shape:SolidMolecular weight:308.37Guaiacol
CAS:Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formula:C7H8O2Purity:99.83%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.14Nitroflurbiprofen
CAS:Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensiveFormula:C19H20FNO5Purity:99.38%Color and Shape:SolidMolecular weight:361.36Ref: TM-T16329
1mg85.00€5mg164.00€10mg245.00€25mg419.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)170.00€Tolfenamic Acid
CAS:Formula:C14H12ClNO2Purity:>97.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:261.71Sudoxicam
CAS:Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edemaFormula:C13H11N3O4S2Purity:100%Color and Shape:SolidMolecular weight:337.37Ref: TM-T16950
2mg42.00€5mg64.00€10mg97.00€25mg183.00€50mg284.00€100mg411.00€200mg585.00€1mL*10mM (DMSO)64.00€Methyl 2-(2,6-Dichloroanilino)phenylacetate
CAS:Formula:C15H13Cl2NO2Purity:>97.0%(GC)(N)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:310.17Loxoprofen
CAS:Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.Formula:C15H18O3Purity:98.25%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:246.3Ref: TM-T0463
1g155.00€10mg34.00€25mg44.00€50mg47.00€100mg59.00€200mg71.00€500mg104.00€1mL*10mM (DMSO)34.00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purity:99.06% - 99.81%Color and Shape:SolidMolecular weight:903.06Aceclofenac
CAS:Formula:C16H13Cl2NO4Purity:98%Color and Shape:SolidMolecular weight:354.18471999999997Tinoridine hydrochloride
CAS:Tinoridine HCl is an NSAID that inhibits lipid peroxides and renin release, unlike indomethacin and corticosteroids.Formula:C17H21ClN2O2SPurity:97.49%Color and Shape:SolidMolecular weight:352.88Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Formula:C8H12ClNO3Purity:96.17% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64Flurbiprofen
CAS:Formula:C15H13FO2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:244.27Ibuprofen
CAS:Formula:C13H18O2Purity:>98.0%(GC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:206.29Diflunisal
CAS:Formula:C13H8F2O3Purity:>98.0%(GC)Color and Shape:White to Almost white powder to crystalineMolecular weight:250.20Catechin
CAS:Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.Formula:C15H14O6Purity:97.34% - 99.82%Color and Shape:SolidMolecular weight:290.27Pelubiprofen
CAS:Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.Formula:C16H18O3Purity:99.69%Color and Shape:SolidMolecular weight:258.312-(3-Benzoylphenyl)propionic acid
CAS:Formula:C16H14O3Purity:98%Color and Shape:SolidMolecular weight:254.2806COX/5-LO-IN-1
CAS:COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.Formula:C16H15FN2O2SPurity:98%Color and Shape:SolidMolecular weight:318.37Hamaudol
CAS:Hamaudol, from Saposhnikovia divaricata, has pain-relief and anti-inflammatory effects, inhibits COX-1/COX-2 (0.30/0.57 mM).Formula:C15H16O5Purity:99.62%Color and Shape:SolidMolecular weight:276.28Meloxicam
CAS:Formula:C14H13N3O4S2Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Green powder to crystalineMolecular weight:351.40(Iso)-Samixogrel
CAS:(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.Formula:C25H25ClN2O4SPurity:98.80%Color and Shape:SolidMolecular weight:484.995-Amino-2-hydroxybenzoic acid
CAS:Formula:C7H7NO3Purity:98%Color and Shape:SolidMolecular weight:153.13538COX-2-IN-51
CAS:COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.Formula:C23H18F4O3SColor and Shape:SolidMolecular weight:450.446Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate
CAS:Formula:C30H28Br2N2Na2O9Purity:99%Color and Shape:SolidMolecular weight:766.3389Jaceosidin
CAS:Jaceosidin: anti-oxidant, anti-inflammatory, anti-cancer, immunosuppressive; affects CYP1A2/UGT1A1/UGT1A7 metabolism.Formula:C17H14O7Purity:98.23% - 99.28%Color and Shape:SolidMolecular weight:330.29Indobufen
CAS:Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor.Formula:C18H17NO3Purity:99.44% - 99.63%Color and Shape:SolidMolecular weight:295.33Anti-inflammatory agent 52
Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29Formula:C24H21ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:452.95COX-1-IN-2
COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.Formula:C29H22FN3OSColor and Shape:SolidMolecular weight:479.57Niflumic acid
CAS:Formula:C13H9F3N2O2Purity:98%Color and Shape:SolidMolecular weight:282.21796959999995Prim-O-glucosylcimifugin
CAS:Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion of G0/G1 phase.Formula:C22H28O11Purity:98.57% - 99.92%Color and Shape:SolidMolecular weight:468.45Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-
CAS:Formula:C16H14N2O3SPurity:%Color and Shape:SolidMolecular weight:314.35895999999997(S)-(+)-Ibuprofen
CAS:Formula:C13H18O2Purity:>98.0%(GC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:206.29COX-2-IN-47
CAS:COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.Formula:C18H18N2O4Color and Shape:SolidMolecular weight:326.35α-Demethylnaproxen
CAS:α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)Formula:C13H12O3Purity:97.57%Color and Shape:Off-White SolidMolecular weight:216.23SC-236
CAS:SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).Formula:C16H11ClF3N3O2SPurity:99.74%Color and Shape:SolidMolecular weight:401.79Mefenamic acid
CAS:Mefenamic acid (CN-35355) is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties.Formula:C15H15NO2Purity:99.32%Color and Shape:Crystals SolidMolecular weight:241.29Naproxen
CAS:Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesicFormula:C14H14O3Purity:99.6% - 99.89%Color and Shape:Crystals From Acetone-Hexane SolidMolecular weight:230.26(-)-Catechin gallate
CAS:(-)-Catechin gallate inhibits 6PGD, IDH, Beta-secretase, and fights chloroquine-sensitive/resistant Plasmodium falciparum.Formula:C22H18O10Purity:100% - 97.74%Color and Shape:SolidMolecular weight:442.37FR 122047
CAS:FR 122047 (1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride) is a potent and selective inhibitor of COX-1 with IC50 of 28 nMFormula:C23H26ClN3O3SPurity:99.63%Color and Shape:SolidMolecular weight:459.99Sulindac
CAS:Formula:C20H17FO3SPurity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:356.41Pectolinarigenin
CAS:Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.Formula:C17H14O6Purity:98.67% - 98.77%Color and Shape:SolidMolecular weight:314.29Ref: TM-T6S0413
1mg48.00€5mg95.00€10mg162.00€25mg280.00€50mg432.00€100mg653.00€1mL*10mM (DMSO)116.00€Bromfenac Sodium Sesquihydrate
CAS:Formula:C15H11BrNaNO3H2OPurity:>98.0%(T)(HPLC)Color and Shape:White to Yellow powder to crystalMolecular weight:383.17Propanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS:Formula:C11H8N2OPurity:98%Color and Shape:SolidMolecular weight:184.194(-)-Ibuprofenamide
CAS:(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.Formula:C13H19NOPurity:98%Color and Shape:SolidMolecular weight:205.32-Ethoxybenzamide
CAS:2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.Formula:C9H11NO2Purity:99.75%Color and Shape:1992)Molecular weight:165.19Tolfenamic Acid
CAS:Tolfenamic Acid (GEA 6414) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.Formula:C14H12ClNO2Purity:99.71% - 99.97%Color and Shape:SolidMolecular weight:261.7Hamaline
CAS:Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.Formula:C20H19ClN2OPurity:99.88%Color and Shape:SoildMolecular weight:338.83Ref: TM-T60053
1mg38.00€5mg72.00€10mg93.00€25mg150.00€50mg213.00€100mg320.00€200mg457.00€1mL*10mM (DMSO)77.00€
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