Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Products of "Cyclooxygenase (COX) Inhibitors"
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Flosulide
CAS:Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.Formula:C16H13F2NO4SPurity:98%Color and Shape:SolidMolecular weight:353.343-Pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]-
CAS:Formula:C13H11ClN2O2Purity:96%Color and Shape:SolidMolecular weight:262.6916(-)-Epicatechin
CAS:(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localizationFormula:C15H14O6Purity:97.34% - 98.55%Color and Shape:SolidMolecular weight:290.27Amfenac Sodium Hydrate
CAS:Amfenac Sodium Hydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.Formula:C15H12NO3·H2O·NaPurity:98.65% - 99.67%Color and Shape:Yellow SolidMolecular weight:295.27Desmethyl Celecoxib
CAS:Demethyl celecoxib, a COX-2 inhibitor with 32 nM IC50, is an anti-inflammatory Celecoxib analog with a 75% yield.Formula:C16H12F3N3O2SPurity:99.42%Color and Shape:SolidMolecular weight:367.35METHYL 2,5-DIHYDROXYCINNAMATE
CAS:Formula:C10H10O4Purity:95%Color and Shape:SolidMolecular weight:194.184(2S)-2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]butanoic acid
CAS:Formula:C18H17NO3Purity:97%Color and Shape:SolidMolecular weight:295.3325Ref: IN-DA01CBW2
1g77.00€5g178.00€10g192.00€25g318.00€5mg29.00€100gTo inquire50mg46.00€100mg49.00€250mg61.00€Timegadine
CAS:Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μMFormula:C20H23N5SPurity:98%Color and Shape:SolidMolecular weight:365.5FR-188582
CAS:FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).Formula:C16H13ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:332.8Celecoxib
CAS:Formula:C17H14F3N3O2SPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:381.37Neuroprotective agent 5
Neuroprotective agent 5 (compound 28) acts as a brain-penetrating agent with anti-neuroinflammatory, antioxidant, and neuroprotective properties. It exhibits potent inhibition of nitric oxide (NO) with an EC50 of 0.49 μM and suppresses the release of pro-inflammatory mediators PGE2 and TNF-α. Additionally, it downregulates the expression of iNOS and COX-2 proteins, facilitating the polarization of BV-2 cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Neuroprotective agent 5 also dose-dependently inhibits acetylcholinesterase (AChE) activity and the aggregation of Aβ42. This compound is useful for research into Alzheimer's disease.Color and Shape:Odour SolidSulindac Sulfide
CAS:Formula:C20H17FO2SPurity:>98.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:340.41Cinchophen
CAS:Cinchophen (Cinconal), an analgesic drug, is utilized in treating gout.Formula:C16H11NO2Purity:99.87%Color and Shape:Needles From Methanol Or Diluted Alcohol SolidMolecular weight:249.262-(Phosphonooxy)benzoic acid
CAS:2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.Formula:C7H7O6PPurity:99.83%Color and Shape:SolidMolecular weight:218.1PTUPB
CAS:PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).Formula:C26H24F3N5O3SPurity:98.35%Color and Shape:SolidMolecular weight:543.56Ref: TM-T12580
1mg81.00€5mg170.00€10mg274.00€25mg512.00€50mg817.00€100mg1,216.00€1mL*10mM (DMSO)205.00€COX-1/2-IN-5
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, andFormula:C21H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:414.47Loxoprofen sodium
CAS:Loxoprofen sodium is a COX-1/COX-2 inhibitor (IC50: 6.5/13.5 μM) used orally for anti-inflammatory and antitumor effects.Formula:C15H17NaO3Purity:100%Color and Shape:SolidMolecular weight:268.28344-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
CAS:Formula:C16H14ClN3O2Purity:99%Color and Shape:SolidMolecular weight:315.75426000000004Benzydamine hydrochloride
CAS:Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.Formula:C19H23N3O·HClPurity:99.01%Color and Shape:The White Crystalline PowderMolecular weight:345.871-Acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate
CAS:Formula:C19H19FO4Purity:99%Color and Shape:LiquidMolecular weight:330.3502Bromfenac Sodium
CAS:Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID) and an orally available COX inhibitor, which has anti-inflammatory activity.Formula:C15H11BrNO3·NaPurity:99.93%Color and Shape:SolidMolecular weight:356.15Methyl salicylate
CAS:Methyl salicylate (Gaultheria oil) is an organic ester. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic.Formula:C8H8O3Purity:99.97%Color and Shape:Colourless To Slightly Yellow LiquidMolecular weight:152.15Imrecoxib
CAS:Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM).Formula:C21H23NO3SPurity:99.94%Color and Shape:SolidMolecular weight:369.48Tenoxicam
CAS:Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.Formula:C13H11N3O4S2Purity:100% - 99.72%Color and Shape:Yellow Crystalline PowderMolecular weight:337.37Pranoprofen
CAS:Formula:C15H13NO3Purity:>98.0%(GC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:255.27Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Formula:C12H17NO3Purity:95.99%Color and Shape:Acicular CrystalMolecular weight:223.27LM-1685
CAS:LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂,IC50分别为0.65 µM 和IC50 = 4.3 μM,是治疗炎症的潜在化合物。Formula:C18H16ClNO4SPurity:99.39%Color and Shape:SolidMolecular weight:377.84SC-560
CAS:Formula:C17H12ClF3N2OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:352.74Imatinib Mesylate
CAS:Formula:C29H31N7O·CH4O3SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:589.72Pranoprofen
CAS:Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.Formula:C15H13NO3Purity:97.98% - 99.88%Color and Shape:SolidMolecular weight:255.27Piroxicam
CAS:Piroxicam (CP-16171) is a non-specific COX inhibitor.Formula:C15H13N3O4SPurity:99.52%Color and Shape:SolidMolecular weight:331.35Nifenazone
CAS:Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.Formula:C17H16N4O2Purity:99.74%Color and Shape:SolidMolecular weight:308.33Imatinib
CAS:Formula:C29H31N7OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:493.62TFAP
CAS:TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitorFormula:C13H10F3N3OPurity:99.87%Color and Shape:SolidMolecular weight:281.23Firocoxib
CAS:Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.Formula:C17H20O5SPurity:99.84%Color and Shape:SolidMolecular weight:336.4[10]-Shogaol
CAS:[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.Formula:C21H32O3Purity:97.64% - 99.79%Color and Shape:SolidMolecular weight:332.48Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate
CAS:Formula:C15H17NaO3Purity:97%Color and Shape:SolidMolecular weight:268.28345000000016,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
CAS:Formula:C16H12O4Purity:>97.0%(T)(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:268.27Anti-inflammatory agent 53
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrestFormula:C24H22N2O4SPurity:98%Color and Shape:SolidMolecular weight:434.51α-Spinasterol
CAS:α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects.Formula:C29H48OPurity:99.58% - 99.58%Color and Shape:SolidMolecular weight:412.69Canolol
CAS:Canolol (Phenol, 4-ethenyl-2,6-dimethoxy-) is an antioxidant phenolic compound that has potential use as a COX-2 inhibitor.Formula:C10H12O3Purity:99.39%Color and Shape:SolidMolecular weight:180.2Propyphenazone
CAS:Propyphenazone: an anti-inflammatory, analgesic, antipyretic pyrazolone; prodrug; COX-2 inhibitor.Formula:C14H18N2OPurity:99.64%Color and Shape:SolidMolecular weight:230.31SC58451
CAS:SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.Formula:C20H19FO2SPurity:100%Color and Shape:SolidMolecular weight:342.43Eicosatetraynoic acid
CAS:ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).Formula:C20H24O2Purity:98%Color and Shape:SolidMolecular weight:296.4PD 153035 Hydrochloride
CAS:Formula:C16H14BrN3O2·HClPurity:>97.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:396.67Indomethacin farnesil
CAS:Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.Formula:C34H40ClNO4Purity:99.84%Color and Shape:SolidMolecular weight:562.14
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