Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Products of "Cyclooxygenase (COX) Inhibitors"
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α-Humulene
CAS:α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatoryFormula:C15H24Purity:97.18% - 97.18%Color and Shape:LiquidMolecular weight:204.35COX-2-IN-52
COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.Formula:C16H13IN4O4S2Color and Shape:SolidMolecular weight:516.333Nitroaspirin
CAS:NCX 4016, a NO-donor nitro-derivative of Aspirin, inhibits COX-1 and triggers apoptosis in ovarian cancer cells by modulating EGFR/PI3K/STAT3 and Bcl-2.Formula:C16H13NO7Purity:99.32%Color and Shape:SolidMolecular weight:331.28Ref: TM-T16328
1mg87.00€5mg187.00€10mg259.00€25mg396.00€50mg487.00€100mg658.00€200mg905.00€1mL*10mM (DMSO)172.00€Polmacoxib
CAS:Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Formula:C18H16FNO4SPurity:97.88%Color and Shape:SolidMolecular weight:361.39Ref: TM-T21294
2mg47.00€5mg70.00€10mg107.00€25mg173.00€50mg259.00€100mg378.00€200mg563.00€1mL*10mM (DMSO)77.00€Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:99.13% - 99.8%Color and Shape:SolidMolecular weight:947.15Ref: TM-T2878
1mg39.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)131.00€hCYP3A4 Fluorogenic substrate 1
CAS:hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.Formula:C19H12FNO2Purity:98.59%Color and Shape:SoildMolecular weight:305.3Ref: TM-T77698
1mg57.00€2mg81.00€5mg120.00€10mg187.00€25mg376.00€50mg597.00€100mg938.00€500mg1,882.00€Valdecoxib
CAS:Formula:C16H14N2O3SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:314.362-(6-Methoxynaphthalen-2-yl)acetic Acid
CAS:Formula:C13H12O3Purity:>95.0%(GC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:216.24Phenacetin
CAS:Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from theFormula:C10H13NO2Purity:99.96% - 99.98%Color and Shape:Monoclinic Prisms Analgesic MedicineMolecular weight:179.22Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Formula:C23H22ClNO2Purity:99.49%Color and Shape:Yellowish SolidMolecular weight:379.88Ref: TM-T6568
5mg47.00€10mg70.00€25mg126.00€50mg187.00€100mg279.00€200mg415.00€500mg658.00€1mL*10mM (DMSO)50.00€Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Formula:C16H12ClNO3Purity:99.78%Color and Shape:SolidMolecular weight:301.72Ref: TM-T19679
1mg202.00€5mg472.00€10mg707.00€25mg1,035.00€50mg1,311.00€100mg1,663.00€1mL*10mM (DMSO)469.00€(±)-Catechin
CAS:(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.Formula:C15H14O6Purity:98.46%Color and Shape:White To Yellow PowderMolecular weight:290.27Fenoprofen Calcium
CAS:Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.Formula:C30H26CaO6Purity:99.24%Color and Shape:SolidMolecular weight:522.6β-Elemonic Acid
CAS:β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects, which inhibits proliferation by inducing hypoploid cells and cell apoptosis.Formula:C30H46O3Purity:98% - 99.8%Color and Shape:SolidMolecular weight:454.687,3',4'-Tri-O-methylluteolin
CAS:7,3',4'-Tri-O-methylluteolin is anti-inflammatory, antibacterial, antifungal, and has moderate antitrypanosomal effects (MIC 19.0 ug/ml).Formula:C18H16O6Purity:98.66% - 98.99%Color and Shape:SolidMolecular weight:328.32Ref: TM-TN1291
1mg87.00€5mg170.00€10mg264.00€25mg452.00€50mg647.00€100mg900.00€1mL*10mM (DMSO)187.00€Niflumic Acid
CAS:Formula:C13H9F3N2O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:282.22NS-398
CAS:Formula:C13H18N2O5SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:314.36Roburic acid
CAS:Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.Formula:C30H48O2Purity:99.88%Color and Shape:SolidMolecular weight:440.7Fenoprofen Calcium hydrate
CAS:Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.Formula:C15H14O3Ca·H2OPurity:100% - 99%Color and Shape:SolidMolecular weight:558.63Etoricoxib
CAS:Formula:C18H15ClN2O2SPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:358.84(+)-Catechin Hydrate
CAS:(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biologicalFormula:C15H16O7Purity:99.03% - 99.96%Color and Shape:SolidMolecular weight:308.28Diclofenac sodium
CAS:Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.Formula:C14H10Cl2NNaO2Purity:99.89% - 99.89%Color and Shape:White Or Off-White PowderMolecular weight:318.13Naproxen Sodium
CAS:Formula:C14H13NaO3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:252.24Indomethacin heptyl ester
CAS:Indomethacin heptyl ester is a non-selective inhibitor of both COX-1 and COX-2Formula:C26H30ClNO4Purity:97.66%Color and Shape:SolidMolecular weight:455.97Ref: TM-T22092
1mg50.00€2mg65.00€5mg120.00€10mg202.00€25mg464.00€50mg677.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)202.00€Aceclofenac
CAS:Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.Formula:C16H13Cl2NO4Purity:100% - 99.74%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:354.18FENOPROFEN CALCIUM SALT, DIHYDRATE
CAS:Formula:C30H30CaO8Purity:98%Color and Shape:SolidMolecular weight:558.6324Suxibuzone
CAS:Suxibuzone is a prodrug for joint/muscle pain relief in horses, derived from phenylbutazone.Formula:C24H26N2O6Purity:99.85%Color and Shape:SolidMolecular weight:438.474-Methylamino antipyrine
CAS:4-Methylamino antipyrine, a Metamizole metabolite, is an analgesic and antipyretic with mild anti-inflammatory effects, also inhibits COX.Formula:C12H15N3OPurity:95.85% - 99.87%Color and Shape:SolidMolecular weight:217.27Ref: TM-T10152
10mg47.00€25mg92.00€50mg124.00€100mg187.00€200mg284.00€500mg472.00€1mL*10mM (DMSO)38.00€Tryptanthrin
CAS:Formula:C15H8N2O2Purity:>98.0%(GC)Color and Shape:White to Light yellow powder to crystalMolecular weight:248.24Zaltoprofen
CAS:Formula:C17H14O3SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:298.362-Amino-5-methyl-3-thiophenecarbonitrile
CAS:2-Amino-5-methyl-3-thiophenecarbonitrile is commonly used in the synthesis of Olanzapine.Formula:C6H6N2SPurity:98.95%Color and Shape:SolidMolecular weight:138.19Aceclofenac
CAS:Formula:C16H13Cl2NO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystallineMolecular weight:354.184-Methylamino antipyrine hydrochloride
CAS:4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.Formula:C12H16ClN3OPurity:98%Color and Shape:SolidMolecular weight:253.733-(4,5-Diphenyloxazol-2-yl)propanoic acid
CAS:Formula:C18H15NO3Purity:98%Color and Shape:SolidMolecular weight:293.3166Loxoprofen Sodium Salt Dihydrate
CAS:Formula:C15H17NaO3·2H2OPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:304.32N-trans-Feruloyltyramine
CAS:NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.Formula:C18H19NO4Purity:100% - 99.81%Color and Shape:SolidMolecular weight:313.35Ref: TM-T3S0645
1mg70.00€5mg170.00€10mg283.00€25mg490.00€50mg700.00€100mg938.00€1mL*10mM (DMSO)175.00€Diclofenac diethylamine
CAS:Formula:C18H22Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:369.2855COX-2-IN-34
CAS:COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.Formula:C13H11NO4Purity:98.08%Color and Shape:SoildMolecular weight:245.23Etodolac
CAS:Formula:C17H21NO3Purity:>98.0%(T)(HPLC)Color and Shape:White to Orange to Green powder to crystalMolecular weight:287.364-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
CAS:Formula:C29H31N7OPurity:98%Color and Shape:SolidMolecular weight:493.6027SC-560
CAS:SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.Formula:C17H12ClF3N2OPurity:99.97%Color and Shape:SolidMolecular weight:352.74Ketoprofen
CAS:Formula:C16H14O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:254.29(-)-Epicatechin gallate
CAS:(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.Formula:C22H18O10Purity:96.65% - 99.72%Color and Shape:SolidMolecular weight:442.37Oxaprozin
CAS:Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formula:C18H15NO3Purity:98.53%Color and Shape:SolidMolecular weight:293.32Dehydroevodiamine
CAS:Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormula:C19H15N3OPurity:99.54%Color and Shape:SolidMolecular weight:301.34GW-406381
CAS:GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2).Formula:C21H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:393.46Rebamipide
CAS:Rebamipide (OPC12759) is a drug enhancing gastric defense by stimulating COX2, prostaglandins, and mucus, while reducing TNF alpha and free radicals.Formula:C19H15ClN2O4Purity:99.48% - 99.9%Color and Shape:White PowderMolecular weight:370.79(S)-(+)-Ibuprofen
CAS:(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).Formula:C13H18O2Purity:99.51% - 99.86%Color and Shape:Colourless Crystalline SolidMolecular weight:206.28Piroxicam
CAS:Formula:C15H13N3O4SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:331.35
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