GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Products of "GluR"
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Found 147 products on this category.
ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Formula:C12H12N6SPurity:99.55%Color and Shape:SolidMolecular weight:272.33Ref: TM-T4500
2mg38.00€5mg58.00€10mg96.00€25mg156.00€50mg243.00€100mg354.00€200mg505.00€1mL*10mM (DMSO)60.00€LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Formula:C18H22FNO2SPurity:99.85%Color and Shape:SolidMolecular weight:335.44Ref: TM-T27951
1mg42.00€5mg87.00€10mg140.00€25mg226.00€50mg324.00€100mg437.00€200mg605.00€1mL*10mM (DMSO)92.00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Formula:C24H27N4NaO7SPurity:98%Color and Shape:SolidMolecular weight:538.55PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Formula:C17H14N2O3Purity:99.31%Color and Shape:SolidMolecular weight:294.3(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Formula:C10H10ClNO6Purity:99.06% - 99.90%Color and Shape:SoildMolecular weight:275.64Ref: TM-T23288L
1mg183.00€5mg462.00€10mg660.00€25mg1,035.00€50mg1,415.00€100mg1,872.00€500mg3,763.00€1mL*10mM (DMSO)415.00€Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Formula:C17H20ClN5O3Purity:99%Color and Shape:SolidMolecular weight:377.83VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Formula:C18H15FN2OPurity:99.65%Color and Shape:SolidMolecular weight:294.32Ref: TM-T29126
1mg57.00€5mg120.00€10mg187.00€25mg376.00€50mg588.00€100mg833.00€1mL*10mM (DMSO)115.00€XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Formula:C15H9IO4Purity:97.41%Color and Shape:SolidMolecular weight:380.13Ref: TM-T21995
1mg62.00€2mg87.00€5mg113.00€10mg207.00€25mg369.00€50mg557.00€100mg797.00€1mL*10mM (DMSO)155.00€DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Formula:C8H9NO4Purity:99.55%Color and Shape:SolidMolecular weight:183.16VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Formula:C13H11ClN2O2Purity:99.09% - 99.86%Color and Shape:SolidMolecular weight:262.69Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Formula:C24H44Cl2N4O3Purity:98.6%Color and Shape:SolidMolecular weight:507.54CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Formula:C9H4N4O4Purity:99.70%Color and Shape:Pale Yellow SolidMolecular weight:232.15Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Formula:C17H18FNO2SPurity:99.48%Color and Shape:SolidMolecular weight:319.39Ref: TM-T3478
1mg35.00€2mg50.00€5mg93.00€10mg131.00€25mg258.00€50mg465.00€100mg680.00€1mL*10mM (DMSO)82.00€JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Formula:C23H25F3N4Color and Shape:SolidMolecular weight:414.47Ref: TM-T8862
1mg37.00€5mg80.00€10mg116.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)93.00€IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Formula:C8H9ClN2O2SPurity:99.73%Color and Shape:SolidMolecular weight:232.69DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Formula:C16H16N2O2Purity:98.34%Color and Shape:SolidMolecular weight:268.31Ref: TM-T22736
1mg35.00€5mg70.00€10mg104.00€25mg202.00€50mg311.00€100mg472.00€500mg1,017.00€1mL*10mM (DMSO)85.00€JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Formula:C14H8ClF3N2O2Color and Shape:SolidMolecular weight:328.67Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Formula:C12H19ClN2O7S2Purity:99.01%Color and Shape:SolidMolecular weight:402.87Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Formula:C18H13ClFN3Purity:98.35%Color and Shape:SolidMolecular weight:325.77Ref: TM-T12717
1mg78.00€5mg169.00€10mg246.00€25mg406.00€50mg562.00€100mg702.00€200mg949.00€1mL*10mM (DMSO)178.00€3-MATIDA
CAS:3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).Formula:C8H9NO4SPurity:98.41% - 99.05%Color and Shape:SolidMolecular weight:215.23KRP-199 sodium
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.Formula:C22H12F3N5Na2O7Purity:96.85%Color and Shape:SoildMolecular weight:561.33Ref: TM-T27748L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€500mg3,734.00€LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Formula:C15H16ClF2NO5SColor and Shape:SolidMolecular weight:395.81JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Formula:C20H17FN2O3Purity:99.24%Color and Shape:SolidMolecular weight:352.36A-794282
CAS:A-794282 is a selective antagonist of mGluR1.Formula:C19H18N4OSPurity:≥98%Color and Shape:SolidMolecular weight:350.44GET73
CAS:GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5.Formula:C13H16F3NO2Purity:99.54%Color and Shape:SolidMolecular weight:275.27Ref: TM-T11393
1mg65.00€5mg131.00€10mg202.00€25mg340.00€50mg452.00€100mg638.00€200mg842.00€1mL*10mM (DMSO)177.00€γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Formula:C7H12N2O5Purity:98%Color and Shape:SolidMolecular weight:204.18VU0483605
CAS:VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.Formula:C20H10Cl3N3O3Purity:97.03%Color and Shape:SolidMolecular weight:446.67Ref: TM-T21747
2mg42.00€5mg64.00€10mg97.00€25mg183.00€50mg284.00€100mg425.00€200mg562.00€1mL*10mM (DMSO)78.00€E4CPG
CAS:E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.Formula:C11H13NO4Purity:99.96%Color and Shape:SolidMolecular weight:223.23L-AP4
CAS:L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Formula:C4H10NO5PPurity:98%Color and Shape:White To Off-White Crystalline PowderMolecular weight:183.1LY-2300559
CAS:LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.Formula:C26H26O6Purity:100%Color and Shape:SolidMolecular weight:434.48Ref: TM-T27932
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Formula:C10H11NO4Purity:98.72%Color and Shape:SolidMolecular weight:209.20VU 0357121
CAS:VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.Formula:C17H17F2NO2Purity:99% - 99.99%Color and Shape:SolidMolecular weight:305.32Fenobam
CAS:Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM).Formula:C11H11ClN4O2Purity:99.93%Color and Shape:SolidMolecular weight:266.68Ref: TM-T15275
1mg35.00€5mg64.00€10mg101.00€25mg170.00€50mg248.00€100mg359.00€200mg497.00€1mL*10mM (DMSO)96.00€DNQX
CAS:DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)Formula:C8H4N4O6Purity:97.15% - 99.10%Color and Shape:Off-White Powder With A Yellow TingeMolecular weight:252.14JNJ-40411813
CAS:JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).Formula:C20H25ClN2OPurity:99.74%Color and Shape:SolidMolecular weight:344.88Ref: TM-TQ0094
1mg55.00€5mg117.00€10mg183.00€25mg306.00€50mg437.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)131.00€S 18986
CAS:S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties inFormula:C10H12N2O2SPurity:99.25%Color and Shape:SolidMolecular weight:224.281H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.Formula:C10H12N2O2SPurity:99.69%Color and Shape:SoildMolecular weight:224.28VU0155041
CAS:VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).Formula:C14H15Cl2NO3Purity:99.52% - 99.56%Color and Shape:SolidMolecular weight:316.18Ref: TM-T3565
2mg40.00€5mg58.00€10mg85.00€25mg145.00€50mg188.00€100mg301.00€200mg435.00€1mL*10mM (DMSO)64.00€(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.Formula:C11H19N2O7PPurity:98.37% - 99.41%Color and Shape:SolidMolecular weight:322.25(RS)-3-Hydroxyphenylglycine
CAS:(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.Formula:C8H9NO3Purity:99.92%Color and Shape:SolidMolecular weight:167.16MSOP
CAS:MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).Formula:C4H10NO6PPurity:98%Color and Shape:SolidMolecular weight:199.1ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Formula:C21H20FNO3Purity:99.09%Color and Shape:SolidMolecular weight:353.39Ref: TM-T23003
1mg35.00€5mg64.00€10mg97.00€25mg207.00€50mg309.00€100mgTo inquire1mL*10mM (DMSO)75.00€(RS)-MCPG
CAS:(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.Formula:C10H11NO4Purity:99.96%Color and Shape:SolidMolecular weight:209.2Ref: TM-T3479
1mg35.00€2mg48.00€5mg70.00€10mg87.00€25mg187.00€50mg338.00€100mg502.00€1mL*10mM (DMSO)74.00€Dipraglurant
CAS:Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.Formula:C16H12FN3Purity:98.7%Color and Shape:SolidMolecular weight:265.29Ref: TM-T15134
1mg97.00€5mg227.00€10mg329.00€25mg723.00€50mg1,064.00€100mg1,415.00€1mL*10mM (DMSO)274.00€VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Formula:C21H15FN2O4Purity:96.68% - 98.44%Color and Shape:SolidMolecular weight:378.35Lu AF21934
CAS:Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).Formula:C14H16Cl2N2O2Purity:97.96%Color and Shape:SolidMolecular weight:315.2AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Formula:C28H30Cl2N2Purity:97.23% - 98.34%Color and Shape:SolidMolecular weight:465.46NBQX Disodium
CAS:NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.Formula:C12H6N4Na2O6SPurity:98.22%Color and Shape:SolidMolecular weight:380.24NBQX
CAS:NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.Formula:C12H8N4O6SPurity:97.66% - 99.42%Color and Shape:SolidMolecular weight:336.28Ref: TM-T4113
1mg40.00€5mg89.00€10mg127.00€25mg246.00€50mg369.00€100mg525.00€200mg757.00€1mL*10mM (DMSO)87.00€LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFormula:C9H13NO4Purity:98%Color and Shape:SolidMolecular weight:199.2GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Formula:C19H21ClN4O3Purity:98.02%Color and Shape:SolidMolecular weight:388.85Foliglurax
CAS:Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).Formula:C23H23N3O3SPurity:98%Color and Shape:SolidMolecular weight:421.51MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFormula:C15H10ClFN2Purity:98%Color and Shape:SolidMolecular weight:272.71cis-PDA
CAS:cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.Formula:C7H11NO4Purity:≥98%Color and Shape:White SolidMolecular weight:173.17Decoglurant
CAS:Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.Formula:C21H11F6N5Purity:99.77%Color and Shape:SolidMolecular weight:447.34Ref: TM-T15090
1mg55.00€5mg117.00€10mg167.00€25mg309.00€50mg434.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)160.00€VU 0364439
CAS:VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).Formula:C18H13Cl2N3O3SPurity:97.90%Color and Shape:SolidMolecular weight:422.29CPPHA
CAS:CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.Formula:C22H15ClN2O4Purity:99.61%Color and Shape:SolidMolecular weight:406.82VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Formula:C14H14Cl2NNaO3Purity:98%Color and Shape:SolidMolecular weight:338.16SIB-1757
CAS:SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)Formula:C12H11N3OPurity:97.37%Color and Shape:SolidMolecular weight:213.24Ref: TM-T8434
2mg39.00€5mg58.00€10mg94.00€25mg170.00€50mg259.00€100mg363.00€200mg509.00€1mL*10mM (DMSO)77.00€FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formula:C17H12FN5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:305.31Ref: TM-T5509
1mg50.00€2mg73.00€5mg111.00€10mg160.00€25mg310.00€50mg419.00€100mg557.00€500mgTo inquire1mL*10mM (DMSO)116.00€VU 0285683
CAS:VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.Formula:C14H7FN4OPurity:99.8%Color and Shape:SolidMolecular weight:266.23Ref: TM-T23509
1mg42.00€5mg90.00€10mg101.00€25mg170.00€50mg235.00€100mg335.00€200mg455.00€1mL*10mM (DMSO)92.00€VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Formula:C16H12F5N3OPurity:99.79%Color and Shape:SolidMolecular weight:357.28Ref: TM-T13321
5mg40.00€10mg58.00€25mg105.00€50mg170.00€100mg259.00€200mg369.00€1mL*10mM (DMSO)44.00€VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Formula:C22H16N4O3Purity:99.63%Color and Shape:SolidMolecular weight:384.39Ref: TM-T23515
2mg34.00€5mg52.00€10mg90.00€25mg170.00€50mg273.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)58.00€CBiPES hydrochloride
CAS:CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.Formula:C21H20ClN3O2SPurity:99.66%Color and Shape:SolidMolecular weight:413.92TCN238
CAS:TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).Formula:C12H11N3Purity:99.90%Color and Shape:SolidMolecular weight:197.24VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Formula:C17H11Cl2N3O2Purity:95.48%Color and Shape:SolidMolecular weight:360.19IEM 1754 2HBr
CAS:IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.Formula:C16H30N2·2HBrPurity:99.71% - 99.72%Color and Shape:SolidMolecular weight:412.25NS-102
CAS:NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.Formula:C12H11N3O4Purity:98.73% - 98.95%Color and Shape:SolidMolecular weight:261.23TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Formula:C14H13N5SPurity:99.84%Color and Shape:SolidMolecular weight:283.35ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Formula:C22H23NO3Purity:99.09%Color and Shape:SolidMolecular weight:349.42Ref: TM-T23000
5mg50.00€10mg80.00€25mg145.00€50mg225.00€100mg339.00€200mg470.00€1mL*10mM (DMSO)51.00€AZD6538
CAS:AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.Formula:C15H6FN5OPurity:98.68%Color and Shape:SolidMolecular weight:291.24MMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Formula:C19H16ClN3O3Purity:99.26%Color and Shape:SolidMolecular weight:369.8CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Formula:C13H13NO4Purity:97.43%Color and Shape:SolidMolecular weight:247.25Ref: TM-T19698
5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€1mL*10mM (DMSO)66.00€LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Formula:C19H19NO4Purity:98.57%Color and Shape:SolidMolecular weight:325.36Caroverine hydrochloride
CAS:Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.Formula:C22H28ClN3O2Purity:98.37% - 98.75%Color and Shape:SolidMolecular weight:401.9Ref: TM-T9133
5mg47.00€10mg70.00€25mg131.00€50mg216.00€100mg378.00€200mg552.00€500mg868.00€1mL*10mM (DMSO)50.00€FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Formula:C18H23FN6OPurity:≥98%Color and Shape:SolidMolecular weight:358.41Ref: TM-T3483
1mg105.00€2mg154.00€5mg227.00€10mg359.00€25mg597.00€50mg842.00€100mg1,130.00€1mL*10mM (DMSO)250.00€ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Formula:C20H17F2N3O2Purity:97% - 99.18%Color and Shape:SolidMolecular weight:369.36Decanoic Acid
CAS:Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.Formula:C10H20O2Purity:98.59%Color and Shape:Crystalline Solid SolidMolecular weight:172.26AZD 9272
CAS:AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.Formula:C14H6F2N4OPurity:97.53%Color and Shape:SolidMolecular weight:284.22CX717
CAS:CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.Formula:C11H11N3O3Purity:100%Color and Shape:SoildMolecular weight:233.23LY-404187
CAS:LY404187 is a positive allosteric modulator of AMPA receptorsFormula:C19H22N2O2SPurity:99.34%Color and Shape:SolidMolecular weight:342.46Ref: TM-T7706
2mg35.00€5mg52.00€10mg90.00€25mg164.00€50mg239.00€100mg339.00€200mg472.00€1mL*10mM (DMSO)58.00€Cyclothiazide
CAS:Cyclothiazide enhances AMPA receptors, prevents desensitization, and boosts glutamic acid response (EC50 = 3.8µM).Formula:C14H16ClN3O4S2Purity:98.23% - 99.49%Color and Shape:Crystals From Dilute Alcohol SolidMolecular weight:389.88(S)-3-Hydroxyphenylglycine
CAS:(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).Formula:C8H9NO3Purity:99.18%Color and Shape:SolidMolecular weight:167.16JNJ16259685
CAS:JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19Formula:C20H23NO3Purity:98.31%Color and Shape:SolidMolecular weight:325.4Ref: TM-T5512
1mg48.00€2mg65.00€5mg90.00€10mg140.00€25mg293.00€50mg449.00€100mg655.00€1mL*10mM (DMSO)100.00€MPEP
CAS:MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.Formula:C14H11NPurity:99.54%Color and Shape:SolidMolecular weight:193.24LSN2463359
CAS:LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.Formula:C16H15N3OPurity:99.36%Color and Shape:SolidMolecular weight:265.31Ref: TM-T27854
2mg35.00€5mg52.00€10mg85.00€25mg170.00€50mg259.00€100mg383.00€200mg545.00€1mL*10mM (DMSO)58.00€VU0650786
CAS:VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.Formula:C18H15ClFN5O2Purity:99.09%Color and Shape:SolidMolecular weight:387.8Ref: TM-T13318
1mg96.00€5mg235.00€10mg329.00€25mg560.00€50mg800.00€100mg1,103.00€1mL*10mM (DMSO)259.00€FITM
CAS:FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).Formula:C18H18FN5OSPurity:97.25%Color and Shape:SolidMolecular weight:371.43Ref: TM-T7292
1mg35.00€2mg47.00€5mg70.00€10mg97.00€25mg187.00€50mg283.00€100mg416.00€1mL*10mM (DMSO)65.00€VU0364770
CAS:VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGluFormula:C12H9ClN2OPurity:99.65% - 99.92%Color and Shape:SolidMolecular weight:232.67EGLU
CAS:EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.Formula:C7H13NO4Purity:99.98%Color and Shape:SolidMolecular weight:175.18DCB
CAS:DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.Formula:C14H10Cl2N2Purity:99.12% - 99.9%Color and Shape:SolidMolecular weight:277.15Ref: TM-T22711
5mg39.00€10mg50.00€25mg105.00€50mg170.00€100mg273.00€200mg378.00€1mL*10mM (DMSO)42.00€(E/Z)-SIB-1893
CAS:(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.Formula:C14H13NPurity:99.92%Color and Shape:SolidMolecular weight:195.26Org-26576
CAS:Org-26576 is a positive allosteric modulator of the AMPA receptor.Formula:C11H12N2O2Purity:99.67%Color and Shape:SolidMolecular weight:204.23Ref: TM-T16402
5mg47.00€10mg70.00€25mg104.00€50mg150.00€100mg256.00€200mg379.00€1mL*10mM (DMSO)50.00€Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Formula:C30H30O4Purity:98%Color and Shape:SolidMolecular weight:454.56Piracetam
CAS:Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.Formula:C6H10N2O2Purity:97.16%Color and Shape:Crystals From Isopropanol SolidMolecular weight:142.16MTEP hydrochloride
CAS:MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)Formula:C11H9ClN2SPurity:99.58%Color and Shape:SolidMolecular weight:236.72AMN082 free base
CAS:AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.Formula:C28H28N2Purity:97.75% - 97.79%Color and Shape:SolidMolecular weight:392.54Ref: TM-T21935L
1mg39.00€5mg78.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€200mg793.00€1mL*10mM (DMSO)89.00€VU-1545
CAS:VU-1545 is mGlu5 positive allosteric modulator.Formula:C22H15FN4O3Purity:98.80%Color and Shape:SolidMolecular weight:402.38Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Formula:C12H20N2O8S2Purity:98%Color and Shape:SolidMolecular weight:384.43NPS2390
CAS:NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)Formula:C19H21N3OPurity:97.13%Color and Shape:SolidMolecular weight:307.39VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Formula:C18H14F2N6OSPurity:98%Color and Shape:SolidMolecular weight:400.41Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Formula:C16H10F3N5Purity:97.38%Color and Shape:SolidMolecular weight:329.28(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Formula:C7H11ClN2O4Color and Shape:SolidMolecular weight:222.63LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Formula:C29H29N7O4Purity:98%Color and Shape:SolidMolecular weight:539.59CDPPB
CAS:CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).Formula:C23H16N4OPurity:99.16%Color and Shape:SolidMolecular weight:364.4YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Formula:C11H8ClN5O4Purity:100%Color and Shape:SolidMolecular weight:309.66ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Formula:C15H16N2OPurity:97.85%Color and Shape:SolidMolecular weight:240.3VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Formula:C16H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:333.41LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Formula:C18H20ClNO4Purity:99% - 99.32%Color and Shape:SoildMolecular weight:349.81LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Formula:C18H23NO4Purity:98.06% - 98.71%Color and Shape:SolidMolecular weight:317.38CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFormula:C19H13ClF3N3OPurity:99.17%Color and Shape:SolidMolecular weight:391.77Ref: TM-T6457
2mg37.00€5mg52.00€10mg93.00€25mg145.00€50mg256.00€100mg349.00€200mg495.00€1mL*10mM (DMSO)58.00€mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Formula:C16H21N3OPurity:98.99%Color and Shape:SolidMolecular weight:271.36VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Formula:C22H28N4OPurity:97.27%Color and Shape:SolidMolecular weight:364.48Ref: TM-T29118
1mg44.00€5mg84.00€10mg114.00€25mg221.00€50mg329.00€100mg490.00€200mg677.00€1mL*10mM (DMSO)95.00€CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFormula:C13H13NO4Purity:99.87%Color and Shape:SolidMolecular weight:247.25Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Formula:C18H11F3N2O3Purity:97.57%Color and Shape:SolidMolecular weight:360.29(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Formula:C9H9NO4Purity:99.96%Color and Shape:SolidMolecular weight:195.17Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Formula:C13H10N2OPurity:99.20%Color and Shape:SolidMolecular weight:210.23BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Formula:C23H14ClF3N4Purity:99.62%Color and Shape:SolidMolecular weight:438.83Licostinel
CAS:Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.Formula:C8H3Cl2N3O4Purity:98.02%Color and Shape:SolidMolecular weight:276.031-BCP
CAS:1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.Formula:C13H15NO3Purity:99.60%Color and Shape:SolidMolecular weight:233.26Chelidamic acid
CAS:Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.Formula:C7H5NO5Purity:98.11%Color and Shape:Pale Yellow PowderMolecular weight:183.12DL-AP3
CAS:DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.Formula:C3H8NO5PPurity:98.18% - ≥98%Color and Shape:White PowderMolecular weight:169.07VU6012962
CAS:VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).Formula:C21H19F3N4O4Purity:97% - 98.31%Color and Shape:SolidMolecular weight:448.4Ref: TM-T13323
1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg236.00€50mg425.00€100mg625.00€1mL*10mM (DMSO)87.00€GYKI 52466 dihydrochloride
CAS:GYKI 52466 dihydrochloride is an AMPA/Kainate receptor antagonist with anticonvulsant activity and can be used to study neurological diseases.Formula:C17H17Cl2N3O2Purity:99.38%Color and Shape:SolidMolecular weight:366.24Pomaglumetad methionil anhydrous
CAS:LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.Formula:C12H18N2O7S2Purity:98%Color and Shape:SolidMolecular weight:366.41CX516
CAS:CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.Formula:C14H15N3OPurity:99.29% - ≥95%Color and Shape:Tan SolidMolecular weight:241.29Transtorine
CAS:Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.Formula:C10H7NO3Purity:99.36%Color and Shape:SolidMolecular weight:189.17HBT1
CAS:HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neuronsFormula:C16H17F3N4O2SPurity:99.52%Color and Shape:SolidMolecular weight:386.39MNI 137
CAS:MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.Formula:C15H9BrN4OPurity:97.21%Color and Shape:SolidMolecular weight:341.16trans-ACPD
CAS:trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.Formula:C7H11NO4Purity:99.53%Color and Shape:SolidMolecular weight:173.17Ref: TM-T3484
1mg48.00€2mg63.00€5mg89.00€10mg147.00€25mg279.00€50mg505.00€100mg730.00€1mL*10mM (DMSO)74.00€CFMTI
CAS:CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.Formula:C19H16FN5OPurity:97.23%Color and Shape:SolidMolecular weight:349.36Ref: TM-T3482
1mg60.00€2mg87.00€5mg127.00€10mg180.00€25mg321.00€50mg455.00€100mg635.00€1mL*10mM (DMSO)140.00€(R)-3,4-DCPG HCl
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatalFormula:C10H10ClNO6Purity:98.36% - 99.89%Color and Shape:SoildMolecular weight:275.64(R)-ADX-47273
CAS:(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).Formula:C20H17F2N3O2Purity:99.87%Color and Shape:SolidMolecular weight:369.36Ref: TM-T13441
2mg42.00€5mg65.00€10mg94.00€25mg170.00€50mg259.00€100mg391.00€200mg545.00€1mL*10mM (DMSO)71.00€AMPA receptor modulator-2
CAS:AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.Formula:C15H6F6N4OSPurity:99.62%Color and Shape:SolidMolecular weight:404.29Ref: TM-T37734
1mg123.00€5mg298.00€10mg393.00€25mg628.00€50mg905.00€100mg1,254.00€1mL*10mM (DMSO)328.00€VU0155094
CAS:VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.Formula:C24H24N2O4SPurity:98.00%Color and Shape:SolidMolecular weight:436.52Ref: TM-T9011
1mg65.00€5mg116.00€10mg170.00€25mg284.00€50mg393.00€100mg567.00€200mg748.00€1mL*10mM (DMSO)134.00€MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Formula:C15H9FN2Purity:98.82%Color and Shape:SolidMolecular weight:236.24Farampator
CAS:Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.Formula:C12H13N3O2Purity:99.76% - 99.83%Color and Shape:SolidMolecular weight:231.25Ref: TM-T3957
2mg34.00€5mg52.00€10mg74.00€25mg140.00€50mg235.00€100mg350.00€200mg497.00€1mL*10mM (DMSO)58.00€JNJ-42153605
CAS:JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).Formula:C22H23F3N4Purity:97.25% - 98.57%Color and Shape:SolidMolecular weight:400.44Ref: TM-T3451
1mg34.00€2mg52.00€5mg81.00€10mg105.00€25mg180.00€50mg279.00€100mg396.00€200mg555.00€1mL*10mM (DMSO)84.00€LY2979165
CAS:LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.Formula:C13H22N6O6SPurity:100.00%Color and Shape:SolidMolecular weight:390.42MPEP hydrochloride
CAS:MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).Formula:C14H12ClNPurity:100% - 99.75%Color and Shape:SolidMolecular weight:229.7AZD-8529 mesylate
CAS:AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).Formula:C25H28F3N5O6SPurity:99.19%Color and Shape:SolidMolecular weight:583.58Ref: TM-T10432L
1mg57.00€5mg120.00€10mg188.00€25mg432.00€50mg747.00€100mg1,093.00€200mg1,454.00€1mL*10mM (DMSO)156.00€LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Formula:C20H19NO5Purity:98.53% - 99.37%Color and Shape:SolidMolecular weight:353.37(1R,2S)-VU0155041
CAS:(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.Formula:C14H15Cl2NO3Purity:99.73%Color and Shape:SolidMolecular weight:316.18KM02894
CAS:KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.Formula:C7H9N3OS2Purity:98.72%Color and Shape:SolidMolecular weight:215.3CMPDA
CAS:CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].Formula:C16H28N2O4S2Purity:98%Color and Shape:SolidMolecular weight:376.53
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