Stem Cell and Derivatives
Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.
Subcategories of "Stem Cell and Derivatives"
- Gamma-secretase
- Hedgehog/Smoothened
- Hippo pathway
- JAK
- Porcupine
- ROCK
- STAT
- Stem Cells
- TGF-beta/Smad
- Wnt/beta-catenin
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Products of "Stem Cell and Derivatives"
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SAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Formula:C28H30Cl3N3OSPurity:100%Color and Shape:SoildMolecular weight:562.984-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Formula:C8H6BrClOPurity:99.56%Color and Shape:White To Beige SolidMolecular weight:233.49exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFormula:C25H19N3O3Purity:97.41%Color and Shape:SolidMolecular weight:409.44Ref: TM-T22775
5mg34.00€10mg52.00€25mg105.00€50mg173.00€100mg279.00€200mg406.00€1mL*10mM (DMSO)44.00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Formula:C31H31F3N8O4Color and Shape:SolidMolecular weight:639.64ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Formula:C18H14N4OSPurity:98.53%Color and Shape:SolidMolecular weight:334.39Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Formula:C95H128F3N25O28S3Purity:99.48%Color and Shape:SolidMolecular weight:2221.37Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Formula:C28H46N6O14S2Purity:98%Color and Shape:SolidMolecular weight:754.83TTP 22
CAS:TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.Formula:C16H14N2O2S2Purity:97.08% - 97.78%Color and Shape:SolidMolecular weight:330.42Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Formula:C18H14N4OSPurity:97.54% - 99.82%Color and Shape:SolidMolecular weight:334.39Ref: TM-T9053
1mg73.00€5mg145.00€10mg220.00€25mg437.00€50mg567.00€100mg805.00€200mg1,111.00€1mL*10mM (DMSO)161.00€Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Formula:C28H26N2O12P2Purity:98.97%Color and Shape:SolidMolecular weight:644.46Ref: TM-T9646
1mg208.00€5mg518.00€10mg740.00€25mg1,093.00€50mg1,473.00€100mg2,015.00€1mL*10mM (DMSO)737.00€Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurity:98.23% - 99.96%Color and Shape:SolidMolecular weight:524.68Ref: TM-T1995
1g625.00€5mg49.00€10mg69.00€50mg113.00€100mg134.00€200mg216.00€500mg472.00€1mL*10mM (DMSO)57.00€Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Formula:C24H25N7O2Color and Shape:SolidMolecular weight:443.50Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formula:C18H21F2N7OPurity:99.8%Color and Shape:SolidMolecular weight:389.4Ref: TM-TQ0010
1mg35.00€5mg74.00€10mg110.00€25mg226.00€50mg411.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)81.00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98.85% - ≥98%Color and Shape:SolidMolecular weight:373.21Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurity:100% - 99.79%Color and Shape:SolidMolecular weight:371.42Ref: TM-T2485
5mg50.00€10mg73.00€25mg90.00€50mg115.00€100mg144.00€200mg188.00€500mg311.00€1mL*10mM (DMSO)69.00€Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Formula:C16H18O4Purity:98.66% - 99.48%Color and Shape:SolidMolecular weight:274.31Ref: TM-TL0008
1mg49.00€2mg65.00€5mg97.00€10mg156.00€25mg255.00€50mg373.00€100mg555.00€1mL*10mM (DMSO)165.00€SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Formula:C14H14ClFN2O2Purity:99.83%Color and Shape:SolidMolecular weight:296.72Ref: TM-T60644
1mg52.00€5mg97.00€10mg149.00€25mg283.00€50mg550.00€100mg792.00€500mg1,605.00€1mL*10mM (DMSO)96.00€JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formula:C26H32FN9O2Purity:98%Color and Shape:SolidMolecular weight:521.59Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurity:99.82%Color and Shape:SolidMolecular weight:343.83Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Formula:C27H41NO2Purity:98.31% - 99.66%Color and Shape:White Crystalline SolidMolecular weight:411.62BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Formula:C22H25N3OPurity:99.75%Color and Shape:SolidMolecular weight:347.45HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFormula:C24H23ClN4O3Purity:95.73%Color and Shape:SolidMolecular weight:450.92Ref: TM-T3460
1mg52.00€5mg97.00€10mg178.00€25mg379.00€50mg645.00€100mg1,026.00€1mL*10mM (DMSO)110.00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Formula:C24H40O2Purity:99.89%Color and Shape:SoildMolecular weight:360.57
