Stem Cell and Derivatives
Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.
Subcategories of "Stem Cell and Derivatives"
- Gamma-secretase
- Hedgehog/Smoothened
- Hippo pathway
- JAK
- Porcupine
- ROCK
- STAT
- Stem Cells
- TGF-beta/Smad
- Wnt/beta-catenin
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Products of "Stem Cell and Derivatives"
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WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formula:C20H22N4Purity:98.09% - 99.09%Color and Shape:SolidMolecular weight:318.42STAT3-IN-3
CAS:STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.Formula:C27H26BrN3O6SPurity:98%Color and Shape:SolidMolecular weight:600.48Dual Cathepsin L/JAK-IN-1
CAS:DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Formula:C19H18ClN5Color and Shape:SolidMolecular weight:351.833Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Formula:C25H21N3OPurity:99.56% - 99.95%Color and Shape:SolidMolecular weight:379.45BMS-911543
CAS:BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Formula:C23H28N8OPurity:97.69% - 99.98%Color and Shape:SolidMolecular weight:432.52Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formula:C21H22N6OPurity:98.72%Color and Shape:SolidMolecular weight:374.44PF-04802367
CAS:PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.Formula:C16H16ClN5O3Purity:98.76%Color and Shape:SolidMolecular weight:361.78Ref: TM-T9611
1mg52.00€5mg105.00€10mg160.00€25mg279.00€50mg420.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)117.00€CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formula:C23H20BrN3OPurity:98.61%Color and Shape:SolidMolecular weight:434.33Ref: TM-T21685
1mg38.00€5mg71.00€10mg105.00€25mg207.00€50mg329.00€100mg472.00€200mg620.00€1mL*10mM (DMSO)87.00€Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurity:98.41%Color and Shape:SolidMolecular weight:319.42Hematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formula:C16H12O6Purity:98%Color and Shape:Dark Brown Crystalline PowderMolecular weight:300.26I3MT-3
CAS:I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.Formula:C17H14N2O2SPurity:99.76%Color and Shape:SolidMolecular weight:310.37Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formula:C18H19F3N6OPurity:100% - 99.45%Color and Shape:SolidMolecular weight:392.38Ref: TM-T2636
1mg38.00€2mg52.00€5mg79.00€10mg110.00€25mg217.00€50mg329.00€100mg494.00€200mg705.00€1mL*10mM (DMSO)88.00€3,5-Bis(4-nitrophenoxy)benzoic acid
CAS:3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It decreases the released levels of Aβ42 and notch-1 Aβ-like peptide 25.Formula:C19H12N2O8Purity:99.14%Color and Shape:SolidMolecular weight:396.31CBT-295
CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.Formula:C18H20ClN3OColor and Shape:SolidMolecular weight:329.82MYF-01-37
CAS:MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formula:C15H17F3N2OPurity:98.72% - 99.46%Color and Shape:SolidMolecular weight:298.3Ref: TM-T22372
2mg40.00€5mg60.00€10mg96.00€25mg170.00€50mg298.00€100mg444.00€500mg938.00€1mL*10mM (DMSO)66.00€SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Formula:C25H25F4N5O2Purity:98.64%Color and Shape:SolidMolecular weight:503.49Crenigacestat
CAS:Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested.Formula:C22H23F3N4O4Purity:97.27% - 98.76%Color and Shape:SolidMolecular weight:464.44VT103
CAS:VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formula:C18H17F3N4O2SPurity:98.73%Color and Shape:SolidMolecular weight:410.41Ref: TM-T62077
1mg124.00€5mg298.00€10mg472.00€25mg817.00€50mg1,198.00€100mg1,730.00€200mg2,337.00€1mL*10mM (DMSO)328.00€Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purity:98% - 99.90%Color and Shape:SolidMolecular weight:349.77Ref: TM-T2259
1mg40.00€2mg51.00€5mg85.00€10mg125.00€25mg207.00€50mg329.00€100mg520.00€500mg1,111.00€1mL*10mM (DMSO)93.00€KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18Ref: TM-T2247
1mg38.00€2mg49.00€5mg70.00€10mg95.00€25mg188.00€50mg319.00€100mg474.00€500mg1,074.00€1mL*10mM (DMSO)74.00€
