Stem Cells
Stem cell inhibitors are compounds that specifically target stem cells and their signaling pathways, affecting their ability to self-renew and differentiate. These inhibitors are crucial in research focused on controlling stem cell behavior, understanding developmental processes, and developing therapies for diseases like cancer, where stem cells are thought to play a key role. At CymitQuimica, we offer a variety of stem cell inhibitors to support your research in regenerative medicine, developmental biology, and oncology.
Products of "Stem Cells"
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BP-1-102
CAS:BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formula:C29H27F5N2O6SPurity:99.25% - 99.81%Color and Shape:SolidMolecular weight:626.59Ref: TM-T3708
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg210.00€50mg354.00€100mg522.00€1mL*10mM (DMSO)104.00€IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purity:97.96% - 98.38%Color and Shape:SolidMolecular weight:353.41CHIR-99021 HCl
CAS:CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formula:C22H19Cl3N8Purity:98.07% - 98.44%Color and Shape:SolidMolecular weight:501.8Ref: TM-T2310L
1mg35.00€2mg52.00€5mg77.00€10mg96.00€25mg163.00€50mg240.00€100mg465.00€200mg675.00€500mg1,026.00€1mL*10mM (DMSO)86.00€BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formula:C21H13BrN2O3Purity:99.77%Color and Shape:SolidMolecular weight:421.24Ref: TM-T14613
1mg34.00€5mg80.00€10mg116.00€25mg221.00€50mg329.00€100mg472.00€200mg652.00€1mL*10mM (DMSO)86.00€JAK-IN-28
CAS:JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formula:C20H18ClN7OPurity:98%Color and Shape:SolidMolecular weight:407.86ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurity:98.06% - 99.72%Color and Shape:SolidMolecular weight:412.26ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formula:C18H12N6OSPurity:98.45%Color and Shape:SolidMolecular weight:360.39Ref: TM-T12747
1mg52.00€5mg117.00€10mg187.00€25mg320.00€50mg472.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)143.00€ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formula:C17H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:327.4(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formula:C28H27N3O3Purity:98%Color and Shape:SolidMolecular weight:453.53YAP/TAZ inhibitor-2
CAS:Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Formula:C19H14F4N4OPurity:98.84%Color and Shape:SoildMolecular weight:390.33Ref: TM-T60218
1mg92.00€2mg119.00€5mg187.00€10mg298.00€25mg502.00€50mg725.00€100mg1,017.00€500mg2,023.00€1mL*10mM (DMSO)207.00€IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formula:C25H19N3O3Purity:98.46% - 99.82%Color and Shape:SolidMolecular weight:409.44IWP 12
CAS:IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.Formula:C18H18N4O2S3Purity:98.88%Color and Shape:SolidMolecular weight:418.56JBJ-02-112-05
CAS:JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formula:C27H20N4O2SPurity:98%Color and Shape:SolidMolecular weight:464.54Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purity:99.94% - 99.98%Color and Shape:SolidMolecular weight:526.45Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formula:C9H9BrN2O3Purity:100% - 99.86%Color and Shape:SolidMolecular weight:273.08Ref: TM-T1965
10mg47.00€25mg77.00€50mg119.00€100mg187.00€200mg279.00€500mg472.00€1mL*10mM (DMSO)34.00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formula:C20H15NO3Purity:96.25% - 97.79%Color and Shape:SolidMolecular weight:317.34MRT-10
CAS:MRT-10 is a Smoothened (Smo) receptor antagonist.Formula:C24H23N3O5SPurity:99.47%Color and Shape:SolidMolecular weight:465.52Ref: TM-T23027
1mg47.00€2mg63.00€5mg96.00€10mg135.00€25mg265.00€50mg378.00€100mg530.00€200mg720.00€1mL*10mM (DMSO)87.00€GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formula:C20H18F2N6O5SColor and Shape:SolidMolecular weight:492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Color and Shape:Odour SolidFM-381
CAS:FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formula:C24H24N6O2Purity:98.44%Color and Shape:SolidMolecular weight:428.49MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purity:99.74%Color and Shape:SolidMolecular weight:252.27JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Formula:C22H23FN4O3SPurity:98.36%Color and Shape:SolidMolecular weight:442.51Ref: TM-T35899
5mg47.00€10mg79.00€25mg144.00€50mg250.00€100mg424.00€200mg568.00€1mL*10mM (DMSO)50.00€Jervine
CAS:Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Formula:C27H39NO3Purity:99.20% - 99.86%Color and Shape:Needles From Methanol + Water SolidMolecular weight:425.6Ref: TM-T3363
5mg70.00€10mg119.00€25mg259.00€50mg499.00€100mg715.00€500mg1,444.00€1mL*10mM (DMSO)74.00€CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formula:C30H33N3Purity:99.41%Color and Shape:SolidMolecular weight:435.6Ref: TM-T62483
2mg35.00€5mg51.00€10mg90.00€25mg164.00€50mg259.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)57.00€S-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Formula:C17H18N6Purity:98%Color and Shape:SolidMolecular weight:306.37BDP9066
CAS:BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formula:C20H24N6Purity:98.18%Color and Shape:SolidMolecular weight:348.44Ref: TM-T14521
1mg57.00€5mg120.00€10mg188.00€25mg432.00€50mg747.00€100mg1,293.00€500mg2,585.00€1mL*10mM (DMSO)133.00€GNF-6231
CAS:GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Formula:C24H25FN6O2Purity:100% - 99.54%Color and Shape:SolidMolecular weight:448.49WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formula:C21H26ClN3O4Purity:99.66%Color and Shape:SolidMolecular weight:419.9Londamocitinib
CAS:Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formula:C28H31F2N7O4SPurity:99.47%Color and Shape:SolidMolecular weight:599.65Ref: TM-T11706
1mg180.00€5mg439.00€10mg597.00€25mg905.00€50mg1,169.00€100mg1,568.00€1mL*10mM (DMSO)567.00€NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formula:C20H11Cl2F3N2O4SPurity:99.50%Color and Shape:SolidMolecular weight:503.28JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formula:C22H24N2O3Purity:≥98% - ≥98.0%Color and Shape:SolidMolecular weight:364.44AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formula:C25H24N4O2Purity:99.96%Color and Shape:SolidMolecular weight:412.48Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formula:C16H16ClN5O2Color and Shape:SolidMolecular weight:345.78NIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formula:C18H20N4OPurity:99.87%Color and Shape:SolidMolecular weight:308.38JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formula:C21H21N5O2Purity:99.21%Color and Shape:SolidMolecular weight:375.42SB-747651A Dihydrochloride
CAS:SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formula:C16H24Cl2N8OPurity:97.02%Color and Shape:SolidMolecular weight:415.32Ref: TM-T9652
1mg73.00€5mg155.00€10mg220.00€25mg369.00€50mg525.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)169.00€MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formula:C25H22F2N4O4SColor and Shape:SolidMolecular weight:512.53IHMT-MST1-58
CAS:IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formula:C21H22N6O3SPurity:98% - 98.48%Color and Shape:SolidMolecular weight:438.5STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormula:C30H27F4N7SPurity:98%Color and Shape:SolidMolecular weight:593.64BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formula:C17H13N5Purity:99.87%Color and Shape:SolidMolecular weight:287.32Ref: TM-T8330
1mg50.00€5mg92.00€10mg140.00€25mg273.00€50mg393.00€100mg557.00€200mg753.00€1mL*10mM (DMSO)138.00€CK2-IN-4
CAS:CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.Formula:C18H11N3O4SPurity:99.72%Color and Shape:SolidMolecular weight:365.36Ponsegromab
CAS:Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Purity:100% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:146.08 kDaFz7-21
CAS:Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formula:C83H114N18O23S2Purity:99.8%Color and Shape:SolidMolecular weight:1796.03STAT3 degrader-2
CAS:STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormula:C59H62N9O13PPurity:98%Color and Shape:SolidMolecular weight:1136.15CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurity:99%Color and Shape:SolidMolecular weight:329.42Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41Ref: TM-TQ0037
1mg85.00€2mg107.00€5mg167.00€10mg284.00€25mg467.00€50mg692.00€100mg938.00€1mL*10mM (DMSO)188.00€JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formula:C30H32N8O5SColor and Shape:SolidMolecular weight:616.69Gossypolone
CAS:Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formula:C30H26O10Purity:96.66%Color and Shape:SolidMolecular weight:546.52M3686
CAS:M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formula:C21H18F3N5O2Color and Shape:SolidMolecular weight:429.395
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