Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Products of "Gamma-secretase"
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CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurity:99.44%Color and Shape:SolidMolecular weight:242.32FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purity:100% - ≥98%Color and Shape:SolidMolecular weight:438.52Ref: TM-T3075
1mg35.00€2mg52.00€5mg74.00€10mg99.00€25mg172.00€50mg311.00€100mg542.00€500mg1,188.00€1mL*10mM (DMSO)82.00€LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purity:97.07%Color and Shape:SolidMolecular weight:409.48Ref: TM-T9015
1mg38.00€5mg85.00€10mg118.00€25mg207.00€50mg306.00€100mg444.00€200mg622.00€1mL*10mM (DMSO)93.00€RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purity:99.58%Color and Shape:SoildMolecular weight:311.31Ref: TM-T35566
1mg40.00€2mg52.00€5mg88.00€10mg137.00€25mg227.00€50mg393.00€100mg567.00€1mL*10mM (DMSO)87.00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Formula:C24H40O2Purity:99.89%Color and Shape:SoildMolecular weight:360.57BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Formula:C26H26F4N4O3Color and Shape:SolidMolecular weight:518.5Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Color and Shape:LiquidAβ42 agonist-1
CAS:Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Formula:C15H11NO2Purity:99.77%Color and Shape:SolidMolecular weight:237.25DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formula:C20H20F2N2O4Purity:99.76%Color and Shape:SolidMolecular weight:390.38
