Porcupine
Porcupine inhibitors are compounds that block the activity of Porcupine, an enzyme that is essential for the secretion and activity of Wnt proteins, which are key regulators of the Wnt signaling pathway. The Wnt pathway is involved in various developmental processes, including stem cell maintenance and differentiation. Inhibiting Porcupine is a strategic approach in cancer research, as it can disrupt Wnt-driven tumorigenesis. At CymitQuimica, we provide Porcupine inhibitors to aid your research in stem cell biology, developmental biology, and cancer therapy.
Products of "Porcupine"
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Found 10 products on this category.
IWP 12
CAS:IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.Formula:C18H18N4O2S3Purity:98.88%Color and Shape:SolidMolecular weight:418.56GNF-6231
CAS:GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Formula:C24H25FN6O2Purity:100% - 99.54%Color and Shape:SolidMolecular weight:448.49WHN-88
CAS:WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.Formula:C18H13I2N3O2Color and Shape:SolidMolecular weight:557.12IWP-2
CAS:IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.Formula:C22H18N4O2S3Purity:96.1% - 99.49%Color and Shape:SolidMolecular weight:466.6IWP L6
CAS:IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).Formula:C25H20N4O2S2Purity:100% - 99.74%Color and Shape:SolidMolecular weight:472.58IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurity:99.12%Color and Shape:SolidMolecular weight:432.48Ref: TM-T5342
2mg39.00€5mg64.00€10mg101.00€25mg163.00€50mg226.00€100mg320.00€200mg459.00€1mL*10mM (DMSO)70.00€LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formula:C23H20N6OPurity:100% - ≥98%Color and Shape:SolidMolecular weight:396.44Ref: TM-T2618
1mg48.00€2mg65.00€5mg96.00€10mg164.00€25mg304.00€50mg545.00€100mg778.00€1mL*10mM (DMSO)96.00€ETC-159
CAS:ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Formula:C19H17N7O3Purity:96.87% - 99.30%Color and Shape:SolidMolecular weight:391.38Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Formula:C25H21N3OPurity:99.56% - 99.95%Color and Shape:SolidMolecular weight:379.45Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Formula:C25H19FN4OPurity:99.15%Color and Shape:SolidMolecular weight:410.44
