Fibroblast Growth Factor Receptor (FGFR)
FGFR inhibitors are targeted therapies that block the activity of fibroblast growth factor receptors (FGFRs), which are involved in cell proliferation, differentiation, and angiogenesis. FGFR signaling contributes to the formation of new blood vessels in tumors, promoting their growth and survival. Inhibiting FGFR can therefore reduce angiogenesis and tumor progression. At CymitQuimica, we provide a range of high-quality FGFR inhibitors to support your research in cancer, developmental biology, and angiogenesis.
Products of "Fibroblast Growth Factor Receptor (FGFR)"
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Recifercept
CAS:Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.Color and Shape:LiquidFGFR-IN-11
CAS:FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Formula:C28H29ClN4O4Purity:98%Color and Shape:SolidMolecular weight:521.01FGFR1 inhibitor-8
FGFR1 inhibitor-8 (Compound 9), an FGFR1 inhibitor with an IC50 of 0.5 nM, binds to the ATP-binding pocket of FGFR1 and exhibits anticancer activity [1].Formula:C26H18ClNO5Purity:98%Color and Shape:SolidMolecular weight:459.88BLU9931
CAS:BLU9931 is the first selective small molecule inhibitor of FGFR4.Formula:C26H22Cl2N4O3Purity:96.958% - 99.85%Color and Shape:SolidMolecular weight:509.38Regorafenib
CAS:Formula:C21H15ClF4N4O3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:482.82FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Formula:C28H32Cl2N6O5Purity:98%Color and Shape:SolidMolecular weight:603.5EOC317
CAS:EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Formula:C27H26F5N7O3Purity:98.00% - 99.26%Color and Shape:SolidMolecular weight:591.53Ref: TM-T4318
1mg117.00€2mg172.00€5mg248.00€10mg418.00€25mgTo inquire50mgTo inquire100mgTo inquire1mL*10mM (DMSO)324.00€Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Formula:C31H33N5O4Purity:98% - 99.92%Color and Shape:SolidMolecular weight:539.62LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Formula:C21H19Cl2N5O2Purity:97.22% - 99.46%Color and Shape:SolidMolecular weight:444.31Ref: TM-T2361
1mg52.00€5mg97.00€10mg160.00€25mg313.00€50mg494.00€100mg742.00€200mg1,008.00€1mL*10mM (DMSO)111.00€U3-1784
U3-1784 is a humanized monoclonal antibody targeting CD334, with anti-cancer activity, used in liver cancer research.Color and Shape:LiquidMolecular weight:145.5AZ8010
CAS:AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.Formula:C27H34N4O3Color and Shape:SolidMolecular weight:462.58S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Formula:C22H22N4O4SPurity:95.35% - 97.4%Color and Shape:SolidMolecular weight:438.5Ref: TM-T3274
1mg47.00€2mg63.00€5mg84.00€10mg96.00€25mg170.00€50mg305.00€100mg558.00€1mL*10mM (DMSO)92.00€Efimosfermin alfa
Efimosfermin alfa is a humanized antibody targeting FGFR1.Color and Shape:Odour LiquidASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Formula:C18H19F2N5O4Purity:99.8% - 99.86%Color and Shape:SolidMolecular weight:407.37Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurity:100% - 99.55%Color and Shape:SolidMolecular weight:498.64Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56NSC 12
CAS:NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.Formula:C24H34F6O3Purity:99.51%Color and Shape:SolidMolecular weight:484.52Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
CAS:Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist.Formula:C26H32N4O8Purity:100% - 99.83%Color and Shape:SolidMolecular weight:528.55SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:98.43%Color and Shape:SolidMolecular weight:451.6Lenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formula:C21H19ClN4O4Purity:98.46% - 99.8000%Color and Shape:SolidMolecular weight:426.85ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Formula:C24H27N7OPurity:99.22% - 99.53%Color and Shape:SolidMolecular weight:429.52Derazantinib
CAS:Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C29H29FN4OPurity:99.71%Color and Shape:SolidMolecular weight:468.57Ref: TM-TQ0228
1mg52.00€5mg116.00€10mg169.00€25mg271.00€50mg401.00€100mg597.00€200mg850.00€1mL*10mM (DMSO)125.00€Irpagratinib
CAS:Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.Formula:C28H32F2N6O5Purity:99.08%Color and Shape:SolidMolecular weight:570.59Ref: TM-T79850
1mg98.00€5mg232.00€10mg373.00€25mg737.00€50mg1,175.00€100mg1,824.00€200mg2,441.00€1mL*10mM (DMSO)291.00€Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Formula:C24H24Cl2N4O4Purity:99.27% - ≥95%Color and Shape:SolidMolecular weight:503.38Ref: TM-T3456
1mg52.00€5mg120.00€10mg177.00€25mg310.00€50mg469.00€100mg707.00€500mg1,415.00€1mL*10mM (DMSO)134.00€Sucralfate
CAS:Sucralfate (Sucrose octasulfate-aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of activeFormula:C12H54Al16O75S8Purity:98%Color and Shape:White Amorphous PowderMolecular weight:2086.75SM27
CAS:SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.Formula:C21H16N2O9S2Purity:98.83%Color and Shape:SolidMolecular weight:504.49TG 100572 Hydrochloride
CAS:TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Formula:C26H27Cl2N5O2Purity:98%Color and Shape:SolidMolecular weight:512.43H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Formula:C29H34Cl2N8O4Purity:97.45%Color and Shape:SolidMolecular weight:629.54Ref: TM-T7738
1mg70.00€5mg169.00€10mg274.00€25mg530.00€50mg748.00€100mg1,064.00€1mL*10mM (DMSO)283.00€ODM-203
CAS:ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor ImmunityFormula:C26H21F2N5O2SPurity:99.85%Color and Shape:SolidMolecular weight:505.54FIIN-4
CAS:FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.Formula:C35H38N8O4Purity:100%Color and Shape:SolidMolecular weight:634.73GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98Ref: TM-T6930
10mg52.00€25mg90.00€50mg96.00€100mg140.00€200mg229.00€500mg359.00€1mL*10mM (DMSO)52.00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Ref: TM-T1792
5mg35.00€10mg51.00€25mg80.00€50mg96.00€100mg144.00€200mg185.00€500mg309.00€1mL*10mM (DMSO)57.00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€FGFR1 inhibitor-17
CAS:FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.Formula:C16H13ClN2O3Color and Shape:SolidMolecular weight:316.739ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Ref: TM-T2358
1mg51.00€2mg72.00€5mg105.00€10mg159.00€25mg279.00€50mg462.00€100mg648.00€1mL*10mM (DMSO)116.00€2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS:Formula:C21H15ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:482.8154Ref: IN-DA00ICN3
1g131.00€5g255.00€10g619.00€25gTo inquire10mg30.00€50mg46.00€100mg56.00€250mg69.00€500mg100.00€PROTAC FGFR1 degrader-1
PROTAC FGFR1 degrader-1 (compound S2H) is a targeted degrader of FGFR1, demonstrating an IC50 of 26.81 nM and a DC50 of 39.78 nM in KG1a cells. This compound is composed of a CRBN-type E3 ligase ligand (blue part) Pomalidomide, a target protein ligand (red part) FGFR1ligand-1, and a PROTAC linker (black part) 9-Bromononanoic acid, together forming the conjugate E3LigaseLigand-linker Conjugate 164.Formula:C46H54N8O8Color and Shape:SolidMolecular weight:846.97Surfen dihydrochloride
CAS:Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a heparin sulfate antagonist with antimicrobial properties and inhibits blockade of signaling.Formula:C21H22Cl2N6OPurity:97.08%Color and Shape:SolidMolecular weight:445.35PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formula:C18H18Cl2N6OPurity:96.78%Color and Shape:SolidMolecular weight:405.28Fanregratinib
CAS:Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.Formula:C27H33ClN6O2Color and Shape:SolidMolecular weight:509.04FGFR4-IN-14
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutantFormula:C27H25Cl2N5O2Purity:98%Color and Shape:SolidMolecular weight:522.43FGFR-IN-16
CAS:FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.Formula:C30H27Cl2N7O4Color and Shape:SolidMolecular weight:620.49Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Formula:C29H34N6O4S2Purity:100% - 97.67%Color and Shape:SolidMolecular weight:594.75Ref: TM-T8544
5mg35.00€10mg51.00€25mg77.00€50mg95.00€100mg144.00€200mg225.00€500mg373.00€1mL*10mM (DMSO)49.00€SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Formula:C18H16N2O4Purity:98%Color and Shape:SolidMolecular weight:324.33Bemarituzumab
CAS:Bemarituzumab: humanized IgG1 antibody inhibits FGFR2b, may be used in cancer research.Purity:SDS-PAGE:95% SEC-HPLC:99.99%Color and Shape:LiquidMolecular weight:144 kDaFGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Formula:C23H22N4OPurity:98.09%Color and Shape:SolidMolecular weight:370.45PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purity:98.20%Color and Shape:SolidMolecular weight:501.62PD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Formula:C28H41N7O3Purity:98.15% - 98.21%Color and Shape:Yellow SolidMolecular weight:523.67Ref: TM-T2642
5mg43.00€10mg57.00€25mg89.00€50mg140.00€100mg221.00€200mg393.00€500mg655.00€1mL*10mM (DMSO)59.00€Ferulic acid sodium
CAS:Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.Formula:C10H9NaO4Purity:99.58%Color and Shape:White Crystalline PowderMolecular weight:216.16FGFR4-IN-1
CAS:FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).Formula:C24H27N7O5Purity:98.96%Color and Shape:SolidMolecular weight:493.52
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