Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
Products of "Trk receptor"
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TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formula:C29H31F3N8OPurity:98%Color and Shape:SolidMolecular weight:564.6BNN-20
CAS:BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Formula:C20H30O2Color and Shape:SolidMolecular weight:302.45Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg42.00€5mg59.00€10mg88.00€25mg111.00€50mg168.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)69.00€Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formula:C29H35F2N7O6SPurity:98%Color and Shape:SolidMolecular weight:647.69Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormula:C33H29F2N5O4SPurity:98.9% - 99.74%Color and Shape:SolidMolecular weight:629.68Ref: TM-T4349
5mg51.00€10mg79.00€25mg137.00€50mg210.00€100mg338.00€200mg535.00€500mg845.00€1mL*10mM (DMSO)72.00€GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formula:C28H21F4N5O2Purity:96.17% - 99.29%Color and Shape:SolidMolecular weight:535.49Ref: TM-T6097
5mg50.00€10mg85.00€25mg124.00€50mg188.00€100mg311.00€200mg404.00€500mg657.00€1mL*10mM (DMSO)56.00€ALE-0540
CAS:ALE-0540: nonpeptidic heterocycle, blocks NGF binding to p75/TrkA and TrkA-mediated signaling.Formula:C14H11N3O5Purity:97.25%Color and Shape:SolidMolecular weight:301.25Ref: TM-T9292
2mg35.00€5mg55.00€10mg88.00€25mg133.00€50mg188.00€100mg269.00€200mg369.00€1mL*10mM (DMSO)60.00€TrkB-IN-1
CAS:TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.Formula:C19H16N2O6Purity:98%Color and Shape:SolidMolecular weight:368.34Type II TRK inhibitor 1
CAS:Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formula:C35H33F3N8O3Purity:98%Color and Shape:SolidMolecular weight:670.68TrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formula:C25H20N4OPurity:98%Color and Shape:SolidMolecular weight:392.45Protein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formula:C29H31F2N7OPurity:98%Color and Shape:SolidMolecular weight:531.6CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formula:C32H31N3O5SPurity:99.92%Color and Shape:SolidMolecular weight:569.67Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurity:99.55% - ≥95%Color and Shape:SolidMolecular weight:380.42PF-06273340
CAS:PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Formula:C23H22ClN7O3Purity:98% - 98.00%Color and Shape:SolidMolecular weight:479.92ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formula:C26H40N4O5Purity:99.16% - 99.16%Color and Shape:SolidMolecular weight:488.62ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormula:C32H26N4O6Purity:98.74%Color and Shape:SolidMolecular weight:562.57ANA-12
CAS:ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.Formula:C22H21N3O3SPurity:99.28% - 99.87%Color and Shape:SolidMolecular weight:407.49NMS-P626
CAS:NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.Formula:C28H35F2N7O4SColor and Shape:SolidMolecular weight:603.68Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formula:C21H22F2N6O2Purity:100% - 99.15%Color and Shape:SolidMolecular weight:428.44Ref: TM-T5995
1mg39.00€5mg79.00€10mg96.00€25mg165.00€50mg250.00€100mg376.00€500mg867.00€1mL*10mM (DMSO)86.00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formula:C27H33ClN2O4Purity:98.18%Color and Shape:SolidMolecular weight:485.01
