Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
Products of "Trk receptor"
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LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Formula:C15H21N3O6Purity:99.56%Color and Shape:SolidMolecular weight:339.34Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formula:C18H24N2OSPurity:99.05%Color and Shape:SolidMolecular weight:316.46PF-06733804
CAS:PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Formula:C20H19F5N4O4Purity:98%Color and Shape:SolidMolecular weight:474.38CG 428
CAS:CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.Formula:C43H43FN10O6Purity:98%Color and Shape:SolidMolecular weight:814.86Ref: TM-T41224
1mg170.00€5mg423.00€10mg623.00€25mg938.00€50mg1,311.00€100mg1,786.00€500mg3,591.00€1mL*10mM (DMSO)437.00€Paltimatrectinib
CAS:Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formula:C20H15F5N6Purity:99.96%Color and Shape:SolidMolecular weight:434.37Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Purity:98%Color and Shape:Odour SolidLarotrectinib sulfate
CAS:Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).Formula:C21H22F2N6O2·H2O4SPurity:98.62% - 99.69%Color and Shape:SolidMolecular weight:526.51Ref: TM-T6880
2mg39.00€5mg57.00€10mg93.00€25mg131.00€50mg163.00€100mg274.00€500mg658.00€1mL*10mM (DMSO)66.00€GW 441756
CAS:GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.Formula:C17H13N3OPurity:97.73% - 99.8%Color and Shape:SolidMolecular weight:275.3TrkA-IN-8
CAS:TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.Formula:C20H16N4Color and Shape:SolidMolecular weight:312.368Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurity:97% - 99.94%Color and Shape:Crystals White To Off-White PowderMolecular weight:313.86Repotrectinib
CAS:Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.Formula:C18H18FN5O2Purity:100% - 99.92%Color and Shape:SolidMolecular weight:355.37Ref: TM-T4071
1mg49.00€2mg70.00€5mg96.00€10mg169.00€25mg296.00€50mg474.00€100mg688.00€1mL*10mM (DMSO)100.00€DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purity:99.28%Color and Shape:SolidMolecular weight:735.8TRK-IN-23
CAS:TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L,Formula:C20H17FN4O2Purity:98%Color and Shape:SolidMolecular weight:364.37CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formula:C24H22Cl2N6O3Purity:98.99% - 99.23%Color and Shape:SolidMolecular weight:513.38Ref: TM-T14921
1mg62.00€2mg87.00€5mg119.00€10mg187.00€25mg313.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)136.00€Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.Color and Shape:Odour LiquidHS-345
CAS:HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.Formula:C19H18N6O2SColor and Shape:SolidMolecular weight:394.45BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurity:98.86%Color and Shape:SolidMolecular weight:461.49Ref: TM-T2349
1mg49.00€2mg70.00€5mg96.00€10mg166.00€25mg328.00€50mg537.00€100mg772.00€1mL*10mM (DMSO)116.00€LOXO-195
CAS:(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formula:C20H21FN6OPurity:97.92%Color and Shape:SolidMolecular weight:380.42PF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purity:98%Color and Shape:SolidMolecular weight:528.49Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formula:C26H21F3N4O4Purity:98.98% - 99.39%Color and Shape:SolidMolecular weight:510.46
