c-RET
c-RET inhibitors target the RET (Rearranged during Transfection) proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth, differentiation, and survival. Abnormal activation of RET signaling can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of cancers such as medullary thyroid carcinoma and non-small cell lung cancer. Inhibiting c-RET can induce apoptosis in cancer cells and is a promising approach in targeted cancer therapy. At CymitQuimica, we offer a variety of high-quality c-RET inhibitors to support your research in oncology, signal transduction, and apoptosis.
Products of "c-RET"
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Found 16 products on this category.
RET-IN-23
CAS:RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.Formula:C28H28FN11Purity:97.46%Color and Shape:SolidMolecular weight:537.59DUN73423
CAS:DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.Formula:C19H16N6OColor and Shape:SolidMolecular weight:344.37RET-IN-3
CAS:RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.Formula:C18H21N5O2Purity:99.52%Color and Shape:SolidMolecular weight:339.39Ref: TM-T9673
1mg94.00€5mg216.00€10mg344.00€25mg645.00€50mg1,017.00€100mg1,568.00€1mL*10mM (DMSO)240.00€Agerafenib hydrochloride
CAS:Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Formula:C24H23ClF3N5O5Purity:98%Color and Shape:SolidMolecular weight:553.92Enbezotinib
CAS:Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Formula:C21H21FN6O3Purity:99.79%Color and Shape:SolidMolecular weight:424.43Ref: TM-T62285
1mg120.00€5mg283.00€10mg445.00€25mg730.00€50mg998.00€100mg1,311.00€1mL*10mM (DMSO)319.00€Selpercatinib
CAS:"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."Formula:C29H31N7O3Purity:100% - 99.89%Color and Shape:SolidMolecular weight:525.6Ref: TM-T8222
2mg35.00€5mg51.00€10mg88.00€25mg170.00€50mg274.00€100mg505.00€200mg730.00€500mg1,093.00€Pralsetinib
CAS:Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918TFormula:C27H32FN9O2Purity:97.88% - 98.1%Color and Shape:SolidMolecular weight:533.6Ref: TM-TQ0277
1mg43.00€2mg56.00€5mg103.00€10mg145.00€25mg283.00€50mg530.00€100mg745.00€1mL*10mM (DMSO)120.00€BBT594
CAS:BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.Formula:C28H30F3N7O3Purity:99.57%Color and Shape:SolidMolecular weight:569.58BT-13
CAS:BT-13 activates RET receptor without GFLs, fostering sensory neuron neurite growth in vitro.Formula:C23H27F4N3O4SPurity:99.23%Color and Shape:SolidMolecular weight:517.54Ref: TM-T10624
1mg43.00€2mg57.00€5mg96.00€10mg134.00€25mg220.00€50mg329.00€100mg470.00€1mL*10mM (DMSO)97.00€Vepafestinib
CAS:Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].Formula:C26H30N6O3Purity:98.54%Color and Shape:SolidMolecular weight:474.55trans-Pralsetinib
CAS:trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).Formula:C27H32FN9O2Purity:98%Color and Shape:SolidMolecular weight:533.6Compound TPX-0046
CAS:Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formula:C21H21FN6O3Purity:99.85%Color and Shape:SoildMolecular weight:424.43SPP-86
CAS:SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.Formula:C16H15N5Purity:98.19%Color and Shape:SolidMolecular weight:277.32Ref: TM-T16923
1mg48.00€5mg96.00€10mg153.00€25mg298.00€50mg472.00€100mg687.00€500mg1,444.00€1mL*10mM (DMSO)96.00€RET V804M-IN-1
CAS:RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).Formula:C19H16N6OPurity:97.94% - 99.62%Color and Shape:SolidMolecular weight:344.37Ref: TM-T8467
1mg38.00€2mg49.00€5mg79.00€10mg96.00€25mg165.00€50mg250.00€100mg354.00€200mg522.00€1mL*10mM (DMSO)87.00€TPX-0046
CAS:TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.Formula:C21H21FN6O3Purity:99.07%Color and Shape:SolidMolecular weight:424.43GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFormula:C22H21F4N3O4Purity:100% - 99.8%Color and Shape:SolidMolecular weight:467.41
