c-Kit
c-Kit inhibitors are compounds that block the activity of the Stem Cell Factor Receptor (c-Kit), a tyrosine kinase that plays a pivotal role in cell survival, proliferation, and differentiation, particularly in hematopoietic cells. Mutations in c-Kit are linked to various cancers, including gastrointestinal stromal tumors (GIST) and leukemia. At CymitQuimica, we provide c-Kit inhibitors to support your research in oncology, hematology, and stem cell biology.
Products of "c-Kit"
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AC710
CAS:AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Formula:C31H42N6O4Purity:99.48%Color and Shape:SolidMolecular weight:562.7Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormula:C33H29F2N5O4SPurity:98.9% - 99.74%Color and Shape:SolidMolecular weight:629.68Ref: TM-T4349
5mg51.00€10mg79.00€25mg137.00€50mg210.00€100mg338.00€200mg535.00€500mg845.00€1mL*10mM (DMSO)72.00€N-Desmethyl imatinib
CAS:N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.Formula:C28H29N7OPurity:98.60%Color and Shape:Off-White To Pale-Yellow SolidMolecular weight:479.58Ref: TM-T11641
1mg92.00€5mg170.00€10mg319.00€25mg540.00€50mg777.00€100mg1,074.00€1mL*10mM (DMSO)178.00€Anti-CD117 Antibody (9H202)
Anti-CD117 Antibody (9H202) is an antibody targeting CD117. Anti-CD117 Antibody (9H202) can be used in ELISA, IHC, FCM.Color and Shape:Odour LiquidLenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Formula:C22H23ClN4O7SPurity:99.03% - 99.79%Color and Shape:SolidMolecular weight:522.96Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formula:C35H30N4O4Purity:100% - 99.47%Color and Shape:SolidMolecular weight:570.64Ref: TM-T3211
1mg51.00€5mg88.00€10mg126.00€25mg216.00€50mg328.00€100mg487.00€500mg1,093.00€1mL*10mM (DMSO)96.00€Anti-C-Kit Antibody-APC (1R766)
Anti-C-Kit Antibody-APC (1R766) is a APC-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-APC (1R766) can be used in FCM.Color and Shape:Odour LiquidAnti-C-Kit Antibody-FITC (8E724)
Anti-C-Kit Antibody-FITC (8E724) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (8E724) can be used in FCM.Color and Shape:Odour Liquidc-Kit-IN-3
CAS:c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).Formula:C26H20ClF3N2O4Purity:99.43%Color and Shape:SolidMolecular weight:516.9Ref: TM-T10651
1mg87.00€5mg162.00€10mg254.00€25mg419.00€50mg562.00€100mg787.00€500mg1,578.00€1mL*10mM (DMSO)334.00€Dovitinib lactate
CAS:Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Formula:C24H27FN6O4Purity:98.44% - 99.54%Color and Shape:SolidMolecular weight:482.51Ref: TM-T7104
5mg51.00€10mg79.00€25mg129.00€50mg213.00€100mg358.00€200mg535.00€500mg843.00€1mL*10mM (DMSO)57.00€CD117 Protein, Mouse, Recombinant (His)
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Color and Shape:Lyophilized PowderMolecular weight:56.63 kDa (predicted). Due to glycosylation, the protein migrates to 75-100 kDa based on Tris-Bis PAGE result.Avapritinib
CAS:Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.Formula:C26H27FN10Purity:96.59% - 99.7%Color and Shape:SolidMolecular weight:498.56Ref: TM-T5109
1mg88.00€5mg187.00€10mg305.00€25mg520.00€50mg748.00€100mg1,026.00€500mg2,072.00€1mL*10mM (DMSO)205.00€AMG-25
CAS:AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Formula:C23H17N5O2Purity:98.16%Color and Shape:SolidMolecular weight:395.41c-Kit Protein, Human, Recombinant (aa 50-190, His)
c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E.Color and Shape:Lyophilized PowderMolecular weight:17.9 kDa (predicted); 18 kDa (reducing conditions)c-Kit Protein, Mouse, Recombinant (hFc)
c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Color and Shape:Lyophilized PowderMolecular weight:82.5 kDa (predicted); 100-110 kDa (reducing condition, due to glycosylation)Anti-C-Kit Antibody-PE (7P530)
Anti-C-Kit Antibody-PE (7P530) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (7P530) can be used in FCM.Color and Shape:Odour LiquidCabozantinib
CAS:Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Formula:C28H24FN3O5Purity:99.59% - 99.88%Color and Shape:SolidMolecular weight:501.51Anti-C-Kit Antibody-FITC (7P530)
Anti-C-Kit Antibody-FITC (7P530) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (7P530) can be used in FCM.Color and Shape:Odour LiquidSU14813
CAS:SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.Formula:C23H27FN4O4Purity:99.72%Color and Shape:SolidMolecular weight:442.48Tyrphostin AG1296
CAS:Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.Formula:C16H14N2O2Purity:99.66% - 99.68%Color and Shape:SolidMolecular weight:266.29Ref: TM-T6711
2mg40.00€5mg58.00€10mg90.00€25mg180.00€50mg279.00€100mg411.00€200mg585.00€1mL*10mM (DMSO)81.00€Flumatinib
CAS:Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Formula:C29H29F3N8OPurity:99.52% - 99.95%Color and Shape:SolidMolecular weight:562.59Ref: TM-T4320
1mg35.00€5mg66.00€10mg87.00€25mg127.00€50mg163.00€100mg273.00€200mg409.00€500mg677.00€1mL*10mM (DMSO)87.00€CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Color and Shape:Lyophilized PowderMolecular weight:58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.c-Kit Protein, Human, Recombinant (aa 540-972, His & GST)
c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Color and Shape:Lyophilized PowderMolecular weight:76.8 kDa (predicted); 68 kDa (reducing conditions)Toceranib
CAS:Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formula:C22H25FN4O2Purity:97.14%Color and Shape:SolidMolecular weight:396.46Anti-C-Kit Antibody-PE (8E724)
Anti-C-Kit Antibody-PE (8E724) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (8E724) can be used in FCM.Color and Shape:Odour LiquidMotesanib
CAS:Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.Formula:C22H23N5OPurity:98% - 98.87%Color and Shape:SolidMolecular weight:373.45Imatinib Mesylate
CAS:Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Formula:C29H31N7O·CH4SO3Purity:100% - 99.97%Color and Shape:White Crystalline PowderMolecular weight:589.71Anti-C-Kit Antibody (8E724)
Anti-C-Kit Antibody (8E724) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (8E724) can be used in FCM.Color and Shape:Odour LiquidMasitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurity:100% - 99.55%Color and Shape:SolidMolecular weight:498.64SKLB4771
CAS:SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Formula:C25H27N7O3S2Purity:100% - 98.27%Color and Shape:SolidMolecular weight:537.66Ref: TM-T2051
1mg66.00€2mg87.00€5mg131.00€10mg187.00€25mg393.00€50mg587.00€100mg835.00€500mg1,700.00€1mL*10mM (DMSO)157.00€Flumatinib mesylate
CAS:Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Formula:C30H33F3N8O4SPurity:99.82%Color and Shape:SolidMolecular weight:658.69Ref: TM-T7861
1mg37.00€5mg88.00€10mg133.00€25mg250.00€50mg393.00€100mg628.00€500mg1,301.00€1mL*10mM (DMSO)139.00€Anti-C-Kit Antibody (9Y519)
Anti-C-Kit Antibody (9Y519) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (9Y519) can be used in ELISA.Color and Shape:Odour LiquidLenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formula:C21H19ClN4O4Purity:98.46% - 99.8000%Color and Shape:SolidMolecular weight:426.85AZD3229
CAS:AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.Formula:C24H26FN7O3Purity:98.83%Color and Shape:SolidMolecular weight:479.51Ref: TM-T5409
1mg44.00€5mg87.00€10mg140.00€25mg248.00€50mg364.00€100mg509.00€200mg698.00€1mL*10mM (DMSO)99.00€Tandutinib
CAS:Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3Formula:C31H42N6O4Purity:99.45% - ≥98%Color and Shape:White SolidMolecular weight:562.7Amuvatinib
CAS:Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.Formula:C23H21N5O3SPurity:98.48% - 99.54%Color and Shape:SolidMolecular weight:447.51Anti-C-Kit Antibody (6X205)
Anti-C-Kit Antibody (6X205) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (6X205) can be used in ELISA.Color and Shape:Odour LiquidGW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98Ref: TM-T6930
10mg52.00€25mg90.00€50mg96.00€100mg140.00€200mg229.00€500mg359.00€1mL*10mM (DMSO)52.00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Ref: TM-T1792
5mg35.00€10mg51.00€25mg80.00€50mg96.00€100mg144.00€200mg185.00€500mg309.00€1mL*10mM (DMSO)57.00€Vimseltinib
CAS:Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Formula:C23H25N7O2Purity:99.05% - 99.57%Color and Shape:SolidMolecular weight:431.49Ref: TM-T10652
1mg92.00€5mg188.00€10mg311.00€25mg533.00€50mg727.00€100mg938.00€1mL*10mM (DMSO)215.00€Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormula:C21H18FN5OPurity:98% - 98.24%Color and Shape:SolidMolecular weight:375.4Ref: TM-T2514
5mg50.00€10mg85.00€25mg126.00€50mg188.00€100mg274.00€200mg505.00€500mg815.00€1mL*10mM (DMSO)52.00€Anti-C-Kit Antibody (7P530)
Anti-C-Kit Antibody (7P530) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (7P530) can be used in FCM.Color and Shape:Odour Liquidc-Kit-IN-1
CAS:c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).Formula:C26H21F2N5O3Purity:98.16% - 98.72%Color and Shape:SolidMolecular weight:489.47Ref: TM-T4332
1mg46.00€2mg59.00€5mg87.00€10mg144.00€25mg304.00€50mg542.00€100mg778.00€500mg1,605.00€1mL*10mM (DMSO)94.00€Protein kinase inhibitor 10
CAS:Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Formula:C14H9FN6S2Color and Shape:SolidMolecular weight:344.39Toceranib Phosphate
CAS:Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.Formula:C22H28FN4O6PPurity:98%Color and Shape:SolidMolecular weight:494.45c-Kit-IN-8
CAS:C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Formula:C24H26FN5O4Color and Shape:SolidMolecular weight:467.49Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Formula:C29H34N6O4S2Purity:100% - 97.67%Color and Shape:SolidMolecular weight:594.75Ref: TM-T8544
5mg35.00€10mg51.00€25mg77.00€50mg95.00€100mg144.00€200mg225.00€500mg373.00€1mL*10mM (DMSO)49.00€Ripretinib
CAS:Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.Formula:C24H21BrFN5O2Purity:99.07%Color and Shape:SolidMolecular weight:510.36Ref: TM-T8482
1mg80.00€5mg167.00€10mg281.00€25mg500.00€50mg727.00€100mg1,198.00€200mg1,596.00€1mL*10mM (DMSO)213.00€Cabozantinib hydrochloride
CAS:Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6Formula:C28H25ClFN3O5Purity:99.97%Color and Shape:SolidMolecular weight:537.96Ref: TM-T5164
1mg44.00€2mg55.00€5mg69.00€10mg97.00€25mg169.00€50mg248.00€100mg349.00€200mg568.00€500mg908.00€c-Kit-IN-2
CAS:c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (Formula:C25H29N9O2SPurity:98%Color and Shape:SolidMolecular weight:519.62
