IGF-1R
IGF-1R inhibitors are compounds that specifically target and inhibit the Insulin-like Growth Factor 1 Receptor (IGF-1R), a receptor tyrosine kinase involved in cellular growth, development, and survival. IGF-1R signaling plays a significant role in cancer progression, making these inhibitors valuable in oncology research. At CymitQuimica, we offer IGF-1R inhibitors to support your research in cancer biology, endocrinology, and targeted therapy development.
Products of "IGF-1R"
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Found 40 products on this category.
GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purity:100% - 99.63%Color and Shape:SolidMolecular weight:532.57MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formula:C19H18N2O4SPurity:99.45% - 99.53%Color and Shape:SolidMolecular weight:370.42Ref: TM-T2607
1mg35.00€2mg50.00€5mg77.00€10mg99.00€25mg154.00€50mg197.00€100mg350.00€1mL*10mM (DMSO)82.00€Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purity:98% - 98.07%Color and Shape:SolidMolecular weight:767Ref: TM-T6S1487
1mg113.00€5mg265.00€10mg426.00€25mg702.00€50mg938.00€100mg1,320.00€1mL*10mM (DMSO)360.00€IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:105.2 kDa (predicted); 172.5 kDa, 117.1 kDa and 49.8 kDa, corresponding to the single chain, α subunit and β subunit respectively (reducing condition, due to glycosylation)Tyrphostin AG 538
CAS:Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formula:C16H11NO5Purity:99.73%Color and Shape:SoildMolecular weight:297.26AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formula:C14H13BrN2OPurity:98% - 99.37%Color and Shape:SolidMolecular weight:305.17AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07%Color and Shape:SolidMolecular weight:485.58WAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Formula:C18H16N2O2Purity:99.77%Color and Shape:SoildMolecular weight:292.33XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg56.00€2mg78.00€5mg99.00€10mg149.00€25mg258.00€50mg393.00€100mg582.00€1mL*10mM (DMSO)110.00€PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purity:99.13%Color and Shape:SolidMolecular weight:341.79PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formula:C18H17Cl2N3O2Purity:99.9%Color and Shape:SolidMolecular weight:378.25Ref: TM-T4324
2mg35.00€5mg48.00€10mg63.00€25mg99.00€50mg172.00€100mg286.00€200mg418.00€1mL*10mM (DMSO)63.00€BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurity:98.86%Color and Shape:SolidMolecular weight:461.49Ref: TM-T2349
1mg49.00€2mg70.00€5mg96.00€10mg166.00€25mg328.00€50mg537.00€100mg772.00€1mL*10mM (DMSO)116.00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:97.07%Color and Shape:SolidMolecular weight:522.04NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurity:96.03% - 99.55%Color and Shape:SolidMolecular weight:439.55MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.3Ref: TM-T8773
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)109.00€IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purity:98.75%Color and Shape:SolidMolecular weight:365.38Ref: TM-T11654
1mg44.00€5mg93.00€10mg131.00€25mg207.00€50mg309.00€100mg459.00€200mg657.00€1mL*10mM (DMSO)93.00€GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formula:C44H47F2N9O5SPurity:98.07% - 99%Color and Shape:SolidMolecular weight:851.96BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFormula:C25H26ClN5O3Purity:99.02%Color and Shape:SolidMolecular weight:479.96AZ7550 trimesylate salt
CAS:AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 inhibits IGF1R activity and can be used in the study of lung cancer.Formula:C30H43N7O11S3Purity:99.24%Color and Shape:SolidMolecular weight:773.9IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formula:C16H14BrNO5SPurity:97.55%Color and Shape:SolidMolecular weight:412.26I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formula:C17H12INO5Purity:96.66%Color and Shape:SolidMolecular weight:437.19Ref: TM-T11593
1mg56.00€5mg119.00€10mg187.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)131.00€cis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formula:C28H31N5OColor and Shape:SolidMolecular weight:453.59Linsitinib
CAS:OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Formula:C26H23N5OPurity:98.98% - ≥95%Color and Shape:SolidMolecular weight:421.49NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formula:C23H25ClN6O3Purity:98.07% - 98.78%Color and Shape:SolidMolecular weight:468.94Ref: TM-T1918
1mg48.00€2mg63.00€5mg101.00€10mg163.00€25mg264.00€50mg378.00€100mg567.00€1mL*10mM (DMSO)101.00€AGL-2263
CAS:AGL-2263 is a blocker of insulin receptor (IR)Formula:C17H10N2O5Color and Shape:SolidMolecular weight:322.27Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formula:C8H5NO2S2Purity:99.77%Color and Shape:SolidMolecular weight:211.26Ref: TM-T71812
1mg96.00€5mg227.00€10mg329.00€25mg567.00€50mg753.00€100mg1,035.00€200mg1,406.00€1mL*10mM (DMSO)250.00€Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Formula:C22H22O8Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:414.41Ref: TM-T6943
5mg64.00€10mg88.00€25mg170.00€50mg316.00€100mg535.00€500mg1,121.00€1mL*10mM (DMSO)69.00€KW-2450 free base
CAS:KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.Formula:C28H29N5O3SPurity:99.11%Color and Shape:SolidMolecular weight:515.63Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurity:100% - 99.77%Color and Shape:SolidMolecular weight:558.14CL-A3-7
CAS:CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.Formula:C24H22Br2F2N2O3Color and Shape:SolidMolecular weight:584.25ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurity:98.27%Color and Shape:SolidMolecular weight:562.48Ref: TM-T10285
1mg52.00€5mg116.00€10mg170.00€25mg340.00€50mg472.00€100mg645.00€1mL*10mM (DMSO)143.00€Insulin(cattle)
CAS:Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Formula:C254H377N65O75S6Purity:98%Color and Shape:SolidMolecular weight:5733.49NBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Formula:C17H11NO7Purity:99.83%Color and Shape:SolidMolecular weight:341.27HNMPA
CAS:HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.Formula:C11H11O4PPurity:99.11%Color and Shape:SolidMolecular weight:238.18Ref: TM-T21761
1mg50.00€2mg65.00€5mg93.00€10mg144.00€25mg301.00€50mg452.00€100mg660.00€500mg1,396.00€1mL*10mM (DMSO)106.00€NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFormula:C28H31N5OPurity:99.22% - 99.79%Color and Shape:SolidMolecular weight:453.58
